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Items: 1 to 20 of 128

1.

Mild cholesterol depletion reduces amyloid-beta production by impairing APP trafficking to the cell surface.

Guardia-Laguarta C, Coma M, Pera M, Clarimón J, Sereno L, Agulló JM, Molina-Porcel L, Gallardo E, Deng A, Berezovska O, Hyman BT, Blesa R, Gómez-Isla T, Lleó A.

J Neurochem. 2009 Jul;110(1):220-30. doi: 10.1111/j.1471-4159.2009.06126.x. Epub 2009 Apr 27.

2.

Oxidative stress up-regulates presenilin 1 in lipid rafts in neuronal cells.

Oda A, Tamaoka A, Araki W.

J Neurosci Res. 2010 Apr;88(5):1137-45. doi: 10.1002/jnr.22271.

PMID:
19885829
3.

Inhibition of Cholesterol Biosynthesis Reduces γ-Secretase Activity and Amyloid-β Generation.

Kim Y, Kim C, Jang HY, Mook-Jung I.

J Alzheimers Dis. 2016;51(4):1057-68. doi: 10.3233/JAD-150982.

PMID:
26923021
4.

[Study on expression of PS1 in APP-PS1 double gene stably transfected cell lines and its relation to gamma-secretase].

Liang P, Pan YX, Zhao XM, Du HZ, Zhang JM.

Zhonghua Bing Li Xue Za Zhi. 2005 May;34(5):297-301. Chinese.

PMID:
16181553
5.

Cholesterol accumulation in Niemann Pick type C (NPC) model cells causes a shift in APP localization to lipid rafts.

Kosicek M, Malnar M, Goate A, Hecimovic S.

Biochem Biophys Res Commun. 2010 Mar 12;393(3):404-9. doi: 10.1016/j.bbrc.2010.02.007. Epub 2010 Feb 6.

6.

Alzheimer's presenilin 1 modulates sorting of APP and its carboxyl-terminal fragments in cerebral neurons in vivo.

Gandy S, Zhang YW, Ikin A, Schmidt SD, Bogush A, Levy E, Sheffield R, Nixon RA, Liao FF, Mathews PM, Xu H, Ehrlich ME.

J Neurochem. 2007 Aug;102(3):619-26. Erratum in: J Neurochem. 2007 Nov;103(3):1272. Bogush, Alexey [added].

7.

Mutations in amyloid precursor protein affect its interactions with presenilin/gamma-secretase.

Herl L, Thomas AV, Lill CM, Banks M, Deng A, Jones PB, Spoelgen R, Hyman BT, Berezovska O.

Mol Cell Neurosci. 2009 Jun;41(2):166-74. doi: 10.1016/j.mcn.2009.02.008. Epub 2009 Mar 9.

8.

Novel role of RanBP9 in BACE1 processing of amyloid precursor protein and amyloid beta peptide generation.

Lakshmana MK, Yoon IS, Chen E, Bianchi E, Koo EH, Kang DE.

J Biol Chem. 2009 May 1;284(18):11863-72. doi: 10.1074/jbc.M807345200. Epub 2009 Feb 27.

9.

Low-density lipoprotein receptor-related protein promotes amyloid precursor protein trafficking to lipid rafts in the endocytic pathway.

Yoon IS, Chen E, Busse T, Repetto E, Lakshmana MK, Koo EH, Kang DE.

FASEB J. 2007 Sep;21(11):2742-52. Epub 2007 Apr 26.

PMID:
17463224
10.

The A673T mutation in the amyloid precursor protein reduces the production of β-amyloid protein from its β-carboxyl terminal fragment in cells.

Kokawa A, Ishihara S, Fujiwara H, Nobuhara M, Iwata M, Ihara Y, Funamoto S.

Acta Neuropathol Commun. 2015 Nov 4;3:66. doi: 10.1186/s40478-015-0247-6.

11.

Excess of nicastrin in brain results in heterozygosity having no effect on endogenous APP processing and amyloid peptide levels in vivo.

Brijbassi S, Amtul Z, Newbigging S, Westaway D, St George-Hyslop P, Rozmahel RF.

Neurobiol Dis. 2007 Feb;25(2):291-6. Epub 2006 Oct 27.

PMID:
17071095
12.

Phosphorylation of amyloid precursor carboxy-terminal fragments enhances their processing by a gamma-secretase-dependent mechanism.

Vingtdeux V, Hamdane M, Gompel M, Bégard S, Drobecq H, Ghestem A, Grosjean ME, Kostanjevecki V, Grognet P, Vanmechelen E, Buée L, Delacourte A, Sergeant N.

Neurobiol Dis. 2005 Nov;20(2):625-37. Epub 2005 Jun 3.

PMID:
15936948
13.

The role of presenilin-1 in the gamma-secretase cleavage of the amyloid precursor protein of Alzheimer's disease.

Octave JN, Essalmani R, Tasiaux B, Menager J, Czech C, Mercken L.

J Biol Chem. 2000 Jan 21;275(3):1525-8.

14.

Alzheimer disease Abeta production in the absence of S-palmitoylation-dependent targeting of BACE1 to lipid rafts.

Vetrivel KS, Meckler X, Chen Y, Nguyen PD, Seidah NG, Vassar R, Wong PC, Fukata M, Kounnas MZ, Thinakaran G.

J Biol Chem. 2009 Feb 6;284(6):3793-803. doi: 10.1074/jbc.M808920200. Epub 2008 Dec 12.

15.

Presenilin 1 regulates the processing of beta-amyloid precursor protein C-terminal fragments and the generation of amyloid beta-protein in endoplasmic reticulum and Golgi.

Xia W, Zhang J, Ostaszewski BL, Kimberly WT, Seubert P, Koo EH, Shen J, Selkoe DJ.

Biochemistry. 1998 Nov 24;37(47):16465-71.

PMID:
9843412
16.

Generation of amyloid-β is reduced by the interaction of calreticulin with amyloid precursor protein, presenilin and nicastrin.

Stemmer N, Strekalova E, Djogo N, Plöger F, Loers G, Lutz D, Buck F, Michalak M, Schachner M, Kleene R.

PLoS One. 2013 Apr 9;8(4):e61299. doi: 10.1371/journal.pone.0061299. Print 2013.

17.

Presenilin complexes with the C-terminal fragments of amyloid precursor protein at the sites of amyloid beta-protein generation.

Xia W, Ray WJ, Ostaszewski BL, Rahmati T, Kimberly WT, Wolfe MS, Zhang J, Goate AM, Selkoe DJ.

Proc Natl Acad Sci U S A. 2000 Aug 1;97(16):9299-304.

18.

Compartmentalization of beta-secretase (Asp2) into low-buoyant density, noncaveolar lipid rafts.

Riddell DR, Christie G, Hussain I, Dingwall C.

Curr Biol. 2001 Aug 21;11(16):1288-93.

19.

Effects of sulindac sulfide on the membrane architecture and the activity of gamma-secretase.

Gamerdinger M, Clement AB, Behl C.

Neuropharmacology. 2008 May;54(6):998-1005. doi: 10.1016/j.neuropharm.2008.02.009. Epub 2008 Feb 19.

PMID:
18359496
20.

Cellular prion protein regulates beta-secretase cleavage of the Alzheimer's amyloid precursor protein.

Parkin ET, Watt NT, Hussain I, Eckman EA, Eckman CB, Manson JC, Baybutt HN, Turner AJ, Hooper NM.

Proc Natl Acad Sci U S A. 2007 Jun 26;104(26):11062-7. Epub 2007 Jun 15.

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