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Items: 1 to 20 of 216

1.

Three-dimensional structure and orientation of rat islet amyloid polypeptide protein in a membrane environment by solution NMR spectroscopy.

Nanga RP, Brender JR, Xu J, Hartman K, Subramanian V, Ramamoorthy A.

J Am Chem Soc. 2009 Jun 17;131(23):8252-61. doi: 10.1021/ja9010095.

2.

Structures of rat and human islet amyloid polypeptide IAPP(1-19) in micelles by NMR spectroscopy.

Nanga RP, Brender JR, Xu J, Veglia G, Ramamoorthy A.

Biochemistry. 2008 Dec 2;47(48):12689-97. doi: 10.1021/bi8014357.

3.

Direct detection of transient alpha-helical states in islet amyloid polypeptide.

Williamson JA, Miranker AD.

Protein Sci. 2007 Jan;16(1):110-7. Epub 2006 Nov 22.

4.

Induction of negative curvature as a mechanism of cell toxicity by amyloidogenic peptides: the case of islet amyloid polypeptide.

Smith PE, Brender JR, Ramamoorthy A.

J Am Chem Soc. 2009 Apr 1;131(12):4470-8. doi: 10.1021/ja809002a.

5.

Helix stabilization precedes aqueous and bilayer-catalyzed fiber formation in islet amyloid polypeptide.

Williamson JA, Loria JP, Miranker AD.

J Mol Biol. 2009 Oct 23;393(2):383-96. doi: 10.1016/j.jmb.2009.07.077. Epub 2009 Jul 30.

7.

A single mutation in the nonamyloidogenic region of islet amyloid polypeptide greatly reduces toxicity.

Brender JR, Hartman K, Reid KR, Kennedy RT, Ramamoorthy A.

Biochemistry. 2008 Dec 2;47(48):12680-8. doi: 10.1021/bi801427c.

8.

Membrane disruption and early events in the aggregation of the diabetes related peptide IAPP from a molecular perspective.

Brender JR, Salamekh S, Ramamoorthy A.

Acc Chem Res. 2012 Mar 20;45(3):454-62. doi: 10.1021/ar200189b. Epub 2011 Sep 25.

9.

Residual structure in islet amyloid polypeptide mediates its interactions with soluble insulin.

Wei L, Jiang P, Yau YH, Summer H, Shochat SG, Mu Y, Pervushin K.

Biochemistry. 2009 Mar 24;48(11):2368-76. doi: 10.1021/bi802097b.

PMID:
19146426
10.

Conserved and cooperative assembly of membrane-bound alpha-helical states of islet amyloid polypeptide.

Knight JD, Hebda JA, Miranker AD.

Biochemistry. 2006 Aug 8;45(31):9496-508.

PMID:
16878984
11.

Dynamic alpha-helix structure of micelle-bound human amylin.

Patil SM, Xu S, Sheftic SR, Alexandrescu AT.

J Biol Chem. 2009 May 1;284(18):11982-91. doi: 10.1074/jbc.M809085200. Epub 2009 Feb 24.

14.

Distinct helix propensities and membrane interactions of human and rat IAPP(1-19) monomers in anionic lipid bilayers.

Guo C, Côté S, Mousseau N, Wei G.

J Phys Chem B. 2015 Feb 26;119(8):3366-76. doi: 10.1021/jp5111357. Epub 2015 Feb 17.

PMID:
25646717
15.

Structural and energetic insight into the cross-seeding amyloid assemblies of human IAPP and rat IAPP.

Zhang M, Hu R, Liang G, Chang Y, Sun Y, Peng Z, Zheng J.

J Phys Chem B. 2014 Jun 26;118(25):7026-36. doi: 10.1021/jp5022246. Epub 2014 Jun 12.

PMID:
24892388
16.

Environmental factors differently affect human and rat IAPP: conformational preferences and membrane interactions of IAPP17-29 peptide derivatives.

Pappalardo G, Milardi D, Magrì A, Attanasio F, Impellizzeri G, La Rosa C, Grasso D, Rizzarelli E.

Chemistry. 2007;13(36):10204-15.

PMID:
17902185
17.

Atomic structures of IAPP (amylin) fusions suggest a mechanism for fibrillation and the role of insulin in the process.

Wiltzius JJ, Sievers SA, Sawaya MR, Eisenberg D.

Protein Sci. 2009 Jul;18(7):1521-30. doi: 10.1002/pro.145.

18.

Structure and dynamics of micelle-bound neuropeptide Y: comparison with unligated NPY and implications for receptor selection.

Bader R, Bettio A, Beck-Sickinger AG, Zerbe O.

J Mol Biol. 2001 Jan 12;305(2):307-29.

PMID:
11124908
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