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Items: 1 to 20 of 134

1.

Inhibition of Notch pathway prevents osteosarcoma growth by cell cycle regulation.

Tanaka M, Setoguchi T, Hirotsu M, Gao H, Sasaki H, Matsunoshita Y, Komiya S.

Br J Cancer. 2009 Jun 16;100(12):1957-65. doi: 10.1038/sj.bjc.6605060. Epub 2009 May 19.

2.

Upregulation of Notch pathway molecules in oral squamous cell carcinoma.

Hijioka H, Setoguchi T, Miyawaki A, Gao H, Ishida T, Komiya S, Nakamura N.

Int J Oncol. 2010 Apr;36(4):817-22.

PMID:
20198324
3.

The overexpression of BAMBI and its involvement in the growth and invasion of human osteosarcoma cells.

Zhou L, Park J, Jang KY, Park HS, Wagle S, Yang KH, Lee KB, Park BH, Kim JR.

Oncol Rep. 2013 Sep;30(3):1315-22. doi: 10.3892/or.2013.2569. Epub 2013 Jun 26.

PMID:
23807684
4.

Alpha-secretase inhibition reduces human glioblastoma stem cell growth in vitro and in vivo by inhibiting Notch.

Floyd DH, Kefas B, Seleverstov O, Mykhaylyk O, Dominguez C, Comeau L, Plank C, Purow B.

Neuro Oncol. 2012 Oct;14(10):1215-26. Epub 2012 Sep 7.

5.

Smoothened as a new therapeutic target for human osteosarcoma.

Hirotsu M, Setoguchi T, Sasaki H, Matsunoshita Y, Gao H, Nagao H, Kunigou O, Komiya S.

Mol Cancer. 2010 Jan 12;9:5. doi: 10.1186/1476-4598-9-5.

6.

PTHrP signaling targets cyclin D1 and induces osteoblastic cell growth arrest.

Datta NS, Chen C, Berry JE, McCauley LK.

J Bone Miner Res. 2005 Jun;20(6):1051-64. Epub 2005 Jan 18.

7.

Downregulation of osteoblast markers and induction of the glial fibrillary acidic protein by oncostatin M in osteosarcoma cells require PKCdelta and STAT3.

Chipoy C, Berreur M, Couillaud S, Pradal G, Vallette F, Colombeix C, Rédini F, Heymann D, Blanchard F.

J Bone Miner Res. 2004 Nov;19(11):1850-61. Epub 2004 Aug 23.

8.

BAZF, a novel component of cullin3-based E3 ligase complex, mediates VEGFR and Notch cross-signaling in angiogenesis.

Ohnuki H, Inoue H, Takemori N, Nakayama H, Sakaue T, Fukuda S, Miwa D, Nishiwaki E, Hatano M, Tokuhisa T, Endo Y, Nose M, Higashiyama S.

Blood. 2012 Mar 15;119(11):2688-98. doi: 10.1182/blood-2011-03-345306. Epub 2012 Jan 25.

9.

PI3K/mTOR inhibition upregulates NOTCH-MYC signalling leading to an impaired cytotoxic response.

Shepherd C, Banerjee L, Cheung CW, Mansour MR, Jenkinson S, Gale RE, Khwaja A.

Leukemia. 2013 Mar;27(3):650-60. doi: 10.1038/leu.2012.285. Epub 2012 Oct 5.

PMID:
23038273
10.

The Forkhead Transcription Factor FOXP2 Is Required for Regulation of p21WAF1/CIP1 in 143B Osteosarcoma Cell Growth Arrest.

Gascoyne DM, Spearman H, Lyne L, Puliyadi R, Perez-Alcantara M, Coulton L, Fisher SE, Croucher PI, Banham AH.

PLoS One. 2015 Jun 2;10(6):e0128513. doi: 10.1371/journal.pone.0128513. eCollection 2015.

11.

Function of Integrin-Linked Kinase in Modulating the Stemness of IL-6-Abundant Breast Cancer Cells by Regulating γ-Secretase-Mediated Notch1 Activation in Caveolae.

Hsu EC, Kulp SK, Huang HL, Tu HJ, Salunke SB, Sullivan NJ, Sun D, Wicha MS, Shapiro CL, Chen CS.

Neoplasia. 2015 Jun;17(6):497-508. doi: 10.1016/j.neo.2015.06.001.

12.

Curcumin inhibits proliferation and invasion of osteosarcoma cells through inactivation of Notch-1 signaling.

Li Y, Zhang J, Ma D, Zhang L, Si M, Yin H, Li J.

FEBS J. 2012 Jun;279(12):2247-59. doi: 10.1111/j.1742-4658.2012.08607.x. Epub 2012 May 21.

13.

Gamma-secretase inhibitor prevents Notch3 activation and reduces proliferation in human lung cancers.

Konishi J, Kawaguchi KS, Vo H, Haruki N, Gonzalez A, Carbone DP, Dang TP.

Cancer Res. 2007 Sep 1;67(17):8051-7.

14.

γ-Secretase inhibitor enhances antitumour effect of radiation in Notch-expressing lung cancer.

Mizugaki H, Sakakibara-Konishi J, Ikezawa Y, Kikuchi J, Kikuchi E, Oizumi S, Dang TP, Nishimura M.

Br J Cancer. 2012 Jun 5;106(12):1953-9. doi: 10.1038/bjc.2012.178. Epub 2012 May 17.

15.

RBPJ is a novel target for rhabdomyosarcoma therapy.

Nagao H, Setoguchi T, Kitamoto S, Ishidou Y, Nagano S, Yokouchi M, Abematsu M, Kawabata N, Maeda S, Yonezawa S, Komiya S.

PLoS One. 2012;7(7):e39268. doi: 10.1371/journal.pone.0039268. Epub 2012 Jul 9.

16.

Inhibition of the Notch-Hey1 axis blocks embryonal rhabdomyosarcoma tumorigenesis.

Belyea BC, Naini S, Bentley RC, Linardic CM.

Clin Cancer Res. 2011 Dec 1;17(23):7324-36. doi: 10.1158/1078-0432.CCR-11-1004. Epub 2011 Sep 23.

17.

gamma-secretase inhibitor induces adipogenesis of adipose-derived stem cells by regulation of Notch and PPAR-gamma.

Huang Y, Yang X, Wu Y, Jing W, Cai X, Tang W, Liu L, Liu Y, Grottkau BE, Lin Y.

Cell Prolif. 2010 Apr;43(2):147-56. doi: 10.1111/j.1365-2184.2009.00661.x.

PMID:
20447060
18.

Notch1 competes with the amyloid precursor protein for gamma-secretase and down-regulates presenilin-1 gene expression.

Lleó A, Berezovska O, Ramdya P, Fukumoto H, Raju S, Shah T, Hyman BT.

J Biol Chem. 2003 Nov 28;278(48):47370-5. Epub 2003 Sep 5.

19.

Doxorubicin Inhibits Proliferation of Osteosarcoma Cells Through Upregulation of the Notch Signaling Pathway.

Ji P, Yu L, Guo WC, Mei HJ, Wang XJ, Chen H, Fang S, Yang J.

Oncol Res. 2014;22(4):185-91. doi: 10.3727/096504015X14343704124340.

PMID:
26351207
20.

Notch-1 regulates Akt signaling pathway and the expression of cell cycle regulatory proteins cyclin D1, CDK2 and p21 in T-ALL cell lines.

Guo D, Ye J, Dai J, Li L, Chen F, Ma D, Ji C.

Leuk Res. 2009 May;33(5):678-85. doi: 10.1016/j.leukres.2008.10.026. Epub 2008 Dec 17.

PMID:
19091404

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