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Items: 1 to 20 of 181


Loss of the pro-apoptotic BH3-only Bcl-2 family member Bim sustains B lymphopoiesis in the absence of IL-7.

Huntington ND, Labi V, Cumano A, Vieira P, Strasser A, Villunger A, Di Santo JP, Alves NL.

Int Immunol. 2009 Jun;21(6):715-25. doi: 10.1093/intimm/dxp043. Epub 2009 May 19.


Puma cooperates with Bim, the rate-limiting BH3-only protein in cell death during lymphocyte development, in apoptosis induction.

Erlacher M, Labi V, Manzl C, Böck G, Tzankov A, Häcker G, Michalak E, Strasser A, Villunger A.

J Exp Med. 2006 Dec 25;203(13):2939-51. Epub 2006 Dec 18.


Interleukin-7 regulates Bim proapoptotic activity in peripheral T-cell survival.

Li WQ, Guszczynski T, Hixon JA, Durum SK.

Mol Cell Biol. 2010 Feb;30(3):590-600. doi: 10.1128/MCB.01006-09. Epub 2009 Nov 23.


Puma indirectly activates Bax to cause apoptosis in the absence of Bid or Bim.

Jabbour AM, Heraud JE, Daunt CP, Kaufmann T, Sandow J, O'Reilly LA, Callus BA, Lopez A, Strasser A, Vaux DL, Ekert PG.

Cell Death Differ. 2009 Apr;16(4):555-63. doi: 10.1038/cdd.2008.179. Epub 2008 Dec 12.


BH3-only proteins Puma and Bim are rate-limiting for gamma-radiation- and glucocorticoid-induced apoptosis of lymphoid cells in vivo.

Erlacher M, Michalak EM, Kelly PN, Labi V, Niederegger H, Coultas L, Adams JM, Strasser A, Villunger A.

Blood. 2005 Dec 15;106(13):4131-8. Epub 2005 Aug 23.


The BH3-only proteins Bim and Puma cooperate to impose deletional tolerance of organ-specific antigens.

Gray DH, Kupresanin F, Berzins SP, Herold MJ, O'Reilly LA, Bouillet P, Strasser A.

Immunity. 2012 Sep 21;37(3):451-62. doi: 10.1016/j.immuni.2012.05.030. Epub 2012 Sep 6.


The NF-kappaB regulator Bcl-3 and the BH3-only proteins Bim and Puma control the death of activated T cells.

Bauer A, Villunger A, Labi V, Fischer SF, Strasser A, Wagner H, Schmid RM, Häcker G.

Proc Natl Acad Sci U S A. 2006 Jul 18;103(29):10979-84. Epub 2006 Jul 10.


Loss of Bim allows precursor B cell survival but not precursor B cell differentiation in the absence of interleukin 7.

Oliver PM, Wang M, Zhu Y, White J, Kappler J, Marrack P.

J Exp Med. 2004 Nov 1;200(9):1179-87.


Genetically defining the mechanism of Puma- and Bim-induced apoptosis.

Garrison SP, Phillips DC, Jeffers JR, Chipuk JE, Parsons MJ, Rehg JE, Opferman JT, Green DR, Zambetti GP.

Cell Death Differ. 2012 Apr;19(4):642-9. doi: 10.1038/cdd.2011.136. Epub 2011 Oct 21.


IL-4 regulates Bim expression and promotes B cell maturation in synergy with BAFF conferring resistance to cell death at negative selection checkpoints.

Granato A, Hayashi EA, Baptista BJ, Bellio M, Nobrega A.

J Immunol. 2014 Jun 15;192(12):5761-75. doi: 10.4049/jimmunol.1300749. Epub 2014 May 16.


Bim controls IL-15 availability and limits engagement of multiple BH3-only proteins.

Kurtulus S, Sholl A, Toe J, Tripathi P, Raynor J, Li KP, Pellegrini M, Hildeman DA.

Cell Death Differ. 2015 Jan;22(1):174-84. doi: 10.1038/cdd.2014.118. Epub 2014 Aug 15.


Bcl-2 homology domain 3-only proteins Puma and Bim mediate the vulnerability of CA1 hippocampal neurons to proteasome inhibition in vivo.

Tsuchiya T, Bonner HP, Engel T, Woods I, Matsushima S, Ward MW, Taki W, Henshall DC, Concannon CG, Prehn JH.

Eur J Neurosci. 2011 Feb;33(3):401-8. doi: 10.1111/j.1460-9568.2010.07538.x. Epub 2010 Dec 31.


Haematopoietic stem cell survival and transplantation efficacy is limited by the BH3-only proteins Bim and Bmf.

Labi V, Bertele D, Woess C, Tischner D, Bock FJ, Schwemmers S, Pahl HL, Geley S, Kunze M, Niemeyer CM, Villunger A, Erlacher M.

EMBO Mol Med. 2013 Jan;5(1):122-36. doi: 10.1002/emmm.201201235. Epub 2012 Nov 24.


BH3-only proteins BIM and PUMA in the regulation of survival and neuronal differentiation of newly generated cells in the adult mouse hippocampus.

Bunk EC, König HG, Bernas T, Engel T, Henshall DC, Kirby BP, Prehn JH.

Cell Death Dis. 2010;1:e15. doi: 10.1038/cddis.2009.13.


Apoptosis regulators Fas and Bim synergistically control T-lymphocyte homeostatic proliferation.

Fortner KA, Bouillet P, Strasser A, Budd RC.

Eur J Immunol. 2010 Nov;40(11):3043-53. doi: 10.1002/eji.201040577. Epub 2010 Oct 27.


The proapoptotic BH3-only proteins Bim and Puma are downstream of endoplasmic reticulum and mitochondrial oxidative stress in pancreatic islets in response to glucotoxicity.

Wali JA, Rondas D, McKenzie MD, Zhao Y, Elkerbout L, Fynch S, Gurzov EN, Akira S, Mathieu C, Kay TW, Overbergh L, Strasser A, Thomas HE.

Cell Death Dis. 2014 Mar 13;5:e1124. doi: 10.1038/cddis.2014.88.


Glucose induces pancreatic islet cell apoptosis that requires the BH3-only proteins Bim and Puma and multi-BH domain protein Bax.

McKenzie MD, Jamieson E, Jansen ES, Scott CL, Huang DC, Bouillet P, Allison J, Kay TW, Strasser A, Thomas HE.

Diabetes. 2010 Mar;59(3):644-52. doi: 10.2337/db09-1151. Epub 2009 Dec 3.


Cell death provoked by loss of interleukin-3 signaling is independent of Bad, Bim, and PI3 kinase, but depends in part on Puma.

Ekert PG, Jabbour AM, Manoharan A, Heraud JE, Yu J, Pakusch M, Michalak EM, Kelly PN, Callus B, Kiefer T, Verhagen A, Silke J, Strasser A, Borner C, Vaux DL.

Blood. 2006 Sep 1;108(5):1461-8. Epub 2006 May 16.


Degradation of Keap1 activates BH3-only proteins Bim and PUMA during hepatocyte lipoapoptosis.

Cazanave SC, Wang X, Zhou H, Rahmani M, Grant S, Durrant DE, Klaassen CD, Yamamoto M, Sanyal AJ.

Cell Death Differ. 2014 Aug;21(8):1303-12. doi: 10.1038/cdd.2014.49. Epub 2014 Apr 25.

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