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Items: 1 to 20 of 695

1.

INT131: a selective modulator of PPAR gamma.

Motani A, Wang Z, Weiszmann J, McGee LR, Lee G, Liu Q, Staunton J, Fang Z, Fuentes H, Lindstrom M, Liu J, Biermann DH, Jaen J, Walker NP, Learned RM, Chen JL, Li Y.

J Mol Biol. 2009 Mar 13;386(5):1301-11.

PMID:
19452630
2.

A novel selective peroxisome proliferator-activator receptor-gamma modulator-SPPARgammaM5 improves insulin sensitivity with diminished adverse cardiovascular effects.

Chang CH, McNamara LA, Wu MS, Muise ES, Tan Y, Wood HB, Meinke PT, Thompson JR, Doebber TW, Berger JP, McCann ME.

Eur J Pharmacol. 2008 Apr 14;584(1):192-201. doi: 10.1016/j.ejphar.2007.12.036.

PMID:
18346728
3.

Halofenate is a selective peroxisome proliferator-activated receptor gamma modulator with antidiabetic activity.

Allen T, Zhang F, Moodie SA, Clemens LE, Smith A, Gregoire F, Bell A, Muscat GE, Gustafson TA.

Diabetes. 2006 Sep;55(9):2523-33.

4.

PAR-1622 is a selective peroxisome proliferator-activated receptor gamma partial activator with preserved antidiabetic efficacy and broader safety profile for fluid retention.

Kim MK, Chae YN, Kim HS, Choi SH, Son MH, Kim SH, Kim JK, Moon HS, Park SK, Shin YA, Kim JG, Lee CH, Lim JI, Shin CY.

Arch Pharm Res. 2009 May;32(5):721-7. doi: 10.1007/s12272-009-1511-8.

PMID:
19471887
5.

T2384, a novel antidiabetic agent with unique peroxisome proliferator-activated receptor gamma binding properties.

Li Y, Wang Z, Furukawa N, Escaron P, Weiszmann J, Lee G, Lindstrom M, Liu J, Liu X, Xu H, Plotnikova O, Prasad V, Walker N, Learned RM, Chen JL.

J Biol Chem. 2008 Apr 4;283(14):9168-76. doi: 10.1074/jbc.M800104200.

6.

A selective peroxisome proliferator-activated receptor gamma modulator with distinct fat cell regulation properties.

Fujimura T, Kimura C, Oe T, Takata Y, Sakuma H, Aramori I, Mutoh S.

J Pharmacol Exp Ther. 2006 Aug;318(2):863-71.

7.

A novel peroxisome proliferator-activated gamma (PPAR gamma) agonist, CLX-0921, has potent antihyperglycemic activity with low adipogenic potential.

Dey D, Medicherla S, Neogi P, Gowri M, Cheng J, Gross C, Sharma SD, Reaven GM, Nag B.

Metabolism. 2003 Aug;52(8):1012-8.

PMID:
12898466
8.

Potent antidiabetic effects of rivoglitazone, a novel peroxisome proliferator-activated receptor-gamma agonist, in obese diabetic rodent models.

Kanda S, Nakashima R, Takahashi K, Tanaka J, Ogawa J, Ogata T, Yachi M, Araki K, Ohsumi J.

J Pharmacol Sci. 2009 Oct;111(2):155-66.

9.

Ameliorating effect of FK614, a novel nonthiazolidinedione peroxisome proliferator-activated receptor gamma agonist, on insulin resistance in Zucker fatty rat.

Minoura H, Takeshita S, Yamamoto T, Mabuchi M, Hirosumi J, Takakura S, Kawamura I, Seki J, Manda T, Ita M, Mutoh S.

Eur J Pharmacol. 2005 Sep 5;519(1-2):182-90.

PMID:
16039648
10.

MBX-102/JNJ39659100, a novel peroxisome proliferator-activated receptor-ligand with weak transactivation activity retains antidiabetic properties in the absence of weight gain and edema.

Gregoire FM, Zhang F, Clarke HJ, Gustafson TA, Sears DD, Favelyukis S, Lenhard J, Rentzeperis D, Clemens LE, Mu Y, Lavan BE.

Mol Endocrinol. 2009 Jul;23(7):975-88. doi: 10.1210/me.2008-0473.

PMID:
19389808
11.

Pharmacological profile of a novel, non-TZD PPARgamma agonist.

Chen X, Osborne MC, Rybczynski PJ, Zeck R, Yang M, Xu J, Zhou L, Cryan E, Tang Y, Demarest KT.

Diabetes Obes Metab. 2005 Sep;7(5):536-46.

PMID:
16050946
12.

An antidiabetic thiazolidinedione is a high affinity ligand for peroxisome proliferator-activated receptor gamma (PPAR gamma).

Lehmann JM, Moore LB, Smith-Oliver TA, Wilkison WO, Willson TM, Kliewer SA.

J Biol Chem. 1995 Jun 2;270(22):12953-6.

13.

PAM-1616, a selective peroxisome proliferator-activated receptor γ modulator with preserved anti-diabetic efficacy and reduced adverse effects.

Kim MK, Chae YN, Choi SH, Moon HS, Son MH, Bae MH, Choi HH, Hur Y, Kim E, Park YH, Park CS, Kim JG, Lim JI, Shin CY.

Eur J Pharmacol. 2011 Jan 15;650(2-3):673-81. doi: 10.1016/j.ejphar.2010.10.044.

PMID:
20974124
14.

Mechanism by which a novel non-thiazolidinedione peroxisome proliferator-activated receptor gamma agonist, FK614, ameliorates insulin resistance in Zucker fatty rats.

Minoura H, Takeshita S, Kimura C, Hirosumi J, Takakura S, Kawamura I, Seki J, Manda T, Mutoh S.

Diabetes Obes Metab. 2007 May;9(3):369-78.

PMID:
17391165
15.

KR-62980: a novel peroxisome proliferator-activated receptor gamma agonist with weak adipogenic effects.

Kim KR, Lee JH, Kim SJ, Rhee SD, Jung WH, Yang SD, Kim SS, Ahn JH, Cheon HG.

Biochem Pharmacol. 2006 Aug 14;72(4):446-54.

PMID:
16797489
16.

PAR-5359, a well-balanced PPARalpha/gamma dual agonist, exhibits equivalent antidiabetic and hypolipidemic activities in vitro and in vivo.

Kim MK, Chae YN, Son MH, Kim SH, Kim JK, Moon HS, Park CS, Bae MH, Kim E, Han T, Choi HH, Shin YA, Ahn BN, Lee CH, Lim JI, Shin CY.

Eur J Pharmacol. 2008 Oct 24;595(1-3):119-25. doi: 10.1016/j.ejphar.2008.07.066.

PMID:
18727927
17.

Antidiabetic and hypolipidemic potential of DRF 2519--a dual activator of PPAR-alpha and PPAR-gamma.

Chakrabarti R, Misra P, Vikramadithyan RK, Premkumar M, Hiriyan J, Datla SR, Damarla RK, Suresh J, Rajagopalan R.

Eur J Pharmacol. 2004 May 3;491(2-3):195-206.

PMID:
15140637
18.

A novel N-aryl tyrosine activator of peroxisome proliferator-activated receptor-gamma reverses the diabetic phenotype of the Zucker diabetic fatty rat.

Brown KK, Henke BR, Blanchard SG, Cobb JE, Mook R, Kaldor I, Kliewer SA, Lehmann JM, Lenhard JM, Harrington WW, Novak PJ, Faison W, Binz JG, Hashim MA, Oliver WO, Brown HR, Parks DJ, Plunket KD, Tong WQ, Menius JA, Adkison K, Noble SA, Willson TM.

Diabetes. 1999 Jul;48(7):1415-24.

PMID:
10389847
19.

Balaglitazone: a second generation peroxisome proliferator-activated receptor (PPAR) gamma (γ) agonist.

Agrawal R, Jain P, Dikshit SN.

Mini Rev Med Chem. 2012 Feb;12(2):87-97. Review.

PMID:
22372600
20.

JTP-426467 acts as a selective antagonist for peroxisome proliferator-activated receptor gamma in vitro and in vivo.

Nishiu J, Ito M, Ishida Y, Kakutani M, Shibata T, Matsushita M, Shindo M.

Diabetes Obes Metab. 2006 Sep;8(5):508-16.

PMID:
16918585
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