Sort by
Items per page

Send to

Choose Destination

Links from PubMed

Items: 1 to 20 of 154


Phosphorylation of p27Kip1 by Epstein-Barr virus protein kinase induces its degradation through SCFSkp2 ubiquitin ligase actions during viral lytic replication.

Iwahori S, Murata T, Kudoh A, Sato Y, Nakayama S, Isomura H, Kanda T, Tsurumi T.

J Biol Chem. 2009 Jul 10;284(28):18923-31. doi: 10.1074/jbc.M109.015123. Epub 2009 May 18.


Phosphorylation of MCM4 at sites inactivating DNA helicase activity of the MCM4-MCM6-MCM7 complex during Epstein-Barr virus productive replication.

Kudoh A, Daikoku T, Ishimi Y, Kawaguchi Y, Shirata N, Iwahori S, Isomura H, Tsurumi T.

J Virol. 2006 Oct;80(20):10064-72.


Skp2-mediated p27(Kip1) degradation during S/G2 phase progression of adipocyte hyperplasia.

Auld CA, Fernandes KM, Morrison RF.

J Cell Physiol. 2007 Apr;211(1):101-11.


Degradation of p27(Kip1) at the G(0)-G(1) transition mediated by a Skp2-independent ubiquitination pathway.

Hara T, Kamura T, Nakayama K, Oshikawa K, Hatakeyama S, Nakayama K.

J Biol Chem. 2001 Dec 28;276(52):48937-43. Epub 2001 Oct 26.


Gene therapy for BCR-ABL+ human CML with dual phosphorylation resistant p27Kip1 and stable RNA interference using an EBV vector.

Sengupta A, Banerjee D, Chandra S, Banerjee S.

J Gene Med. 2006 Oct;8(10):1251-61.


BCR-ABL induces the expression of Skp2 through the PI3K pathway to promote p27Kip1 degradation and proliferation of chronic myelogenous leukemia cells.

Andreu EJ, Lledó E, Poch E, Ivorra C, Albero MP, Martínez-Climent JA, Montiel-Duarte C, Rifón J, Pérez-Calvo J, Arbona C, Prósper F, Pérez-Roger I.

Cancer Res. 2005 Apr 15;65(8):3264-72.


Retinoic acid stabilizes p27Kip1 in EBV-immortalized lymphoblastoid B cell lines through enhanced proteasome-dependent degradation of the p45Skp2 and Cks1 proteins.

Zancai P, Dal Col J, Piccinin S, Guidoboni M, Cariati R, Rizzo S, Boiocchi M, Maestro R, Dolcetti R.

Oncogene. 2005 Apr 7;24(15):2483-94.


Ubiquitination of p27Kip1 requires physical interaction with cyclin E and probable phosphate recognition by SKP2.

Ungermannova D, Gao Y, Liu X.

J Biol Chem. 2005 Aug 26;280(34):30301-9. Epub 2005 Jun 24.


Small interfering RNA targeting of S phase kinase-interacting protein 2 inhibits cell growth of oral cancer cells by inhibiting p27 degradation.

Kudo Y, Kitajima S, Ogawa I, Kitagawa M, Miyauchi M, Takata T.

Mol Cancer Ther. 2005 Mar;4(3):471-6.


Epstein-Barr virus BGLF4 kinase downregulates NF-κB transactivation through phosphorylation of coactivator UXT.

Chang LS, Wang JT, Doong SL, Lee CP, Chang CW, Tsai CH, Yeh SW, Hsieh CY, Chen MR.

J Virol. 2012 Nov;86(22):12176-86. doi: 10.1128/JVI.01918-12. Epub 2012 Aug 29.


BGLF4 kinase modulates the structure and transport preference of the nuclear pore complex to facilitate nuclear import of Epstein-Barr virus lytic proteins.

Chang CW, Lee CP, Su MT, Tsai CH, Chen MR.

J Virol. 2015 Feb;89(3):1703-18. doi: 10.1128/JVI.02880-14. Epub 2014 Nov 19.


The F-box protein SKP2 binds to the phosphorylated threonine 380 in cyclin E and regulates ubiquitin-dependent degradation of cyclin E.

Yeh KH, Kondo T, Zheng J, Tsvetkov LM, Blair J, Zhang H.

Biochem Biophys Res Commun. 2001 Mar 9;281(4):884-90.


Tuberin binds p27 and negatively regulates its interaction with the SCF component Skp2.

Rosner M, Hengstschläger M.

J Biol Chem. 2004 Nov 19;279(47):48707-15. Epub 2004 Sep 8.


Removal of Cdk inhibitors through both sequestration and downregulation in zearalenone-treated MCF-7 breast cancer cells.

Ahamed S, Foster JS, Bukovsky A, Diehl JA, Wimalasena J.

Mol Carcinog. 2002 May;34(1):45-58.


Detection of Epstein-Barr virus BGLF4 protein kinase in virus replication compartments and virus particles.

Wang JT, Yang PW, Lee CP, Han CH, Tsai CH, Chen MR.

J Gen Virol. 2005 Dec;86(Pt 12):3215-25.


Effect of phosphorylation on the transactivation activity of Epstein-Barr virus BMRF1, a major target of the viral BGLF4 kinase.

Yang PW, Chang SS, Tsai CH, Chao YH, Chen MR.

J Gen Virol. 2008 Apr;89(Pt 4):884-95. doi: 10.1099/vir.0.83546-0.


The atr protein kinase controls UV-dependent upregulation of p16INK4A through inhibition of Skp2-related polyubiquitination/degradation.

Al-Khalaf HH, Hendrayani SF, Aboussekhra A.

Mol Cancer Res. 2011 Mar;9(3):311-9. doi: 10.1158/1541-7786.MCR-10-0506. Epub 2011 Jan 26.


Gallic acid induces G2/M phase arrest of breast cancer cell MCF-7 through stabilization of p27(Kip1) attributed to disruption of p27(Kip1)/Skp2 complex.

Hsu JD, Kao SH, Ou TT, Chen YJ, Li YJ, Wang CJ.

J Agric Food Chem. 2011 Mar 9;59(5):1996-2003. doi: 10.1021/jf103656v. Epub 2011 Feb 7.


Cyclin D1 overexpression induces progestin resistance in T-47D breast cancer cells despite p27(Kip1) association with cyclin E-Cdk2.

Musgrove EA, Hunter LJ, Lee CS, Swarbrick A, Hui R, Sutherland RL.

J Biol Chem. 2001 Dec 14;276(50):47675-83. Epub 2001 Oct 4.

Supplemental Content

Support Center