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Items: 1 to 20 of 225

1.

Trypanocidal activity of 8-methyl-5'-{[(Z)-4-aminobut-2-enyl]-(methylamino)}adenosine (Genz-644131), an adenosylmethionine decarboxylase inhibitor.

Bacchi CJ, Barker RH Jr, Rodriguez A, Hirth B, Rattendi D, Yarlett N, Hendrick CL, Sybertz E.

Antimicrob Agents Chemother. 2009 Aug;53(8):3269-72. doi: 10.1128/AAC.00076-09. Epub 2009 May 18.

2.

Novel S-adenosylmethionine decarboxylase inhibitors for the treatment of human African trypanosomiasis.

Barker RH Jr, Liu H, Hirth B, Celatka CA, Fitzpatrick R, Xiang Y, Willert EK, Phillips MA, Kaiser M, Bacchi CJ, Rodriguez A, Yarlett N, Klinger JD, Sybertz E.

Antimicrob Agents Chemother. 2009 May;53(5):2052-8. doi: 10.1128/AAC.01674-08. Epub 2009 Mar 16.

3.
4.

Discovery of new S-adenosylmethionine decarboxylase inhibitors for the treatment of Human African Trypanosomiasis (HAT).

Hirth B, Barker RH Jr, Celatka CA, Klinger JD, Liu H, Nare B, Nijjar A, Phillips MA, Sybertz E, Willert EK, Xiang Y.

Bioorg Med Chem Lett. 2009 Jun 1;19(11):2916-9. doi: 10.1016/j.bmcl.2009.04.096. Epub 2009 Apr 24.

PMID:
19419862
5.

In vivo trypanocidal activities of new S-adenosylmethionine decarboxylase inhibitors.

Bacchi CJ, Brun R, Croft SL, Alicea K, B├╝hler Y.

Antimicrob Agents Chemother. 1996 Jun;40(6):1448-53.

9.

Synthesis and evaluation of analogues of 5'-([(Z)-4-amino-2-butenyl]methylamino)-5'-deoxyadenosine as inhibitors of tumor cell growth, trypanosomal growth, and HIV-1 infectivity.

Marasco CJ Jr, Kramer DL, Miller J, Porter CW, Bacchi CJ, Rattendi D, Kucera L, Iyer N, Bernacki R, Pera P, Sufrin JR.

J Med Chem. 2002 Nov 7;45(23):5112-22.

PMID:
12408722
10.

Trypanocidal activity of piperazine-linked bisbenzamidines and bisbenzamidoxime, an orally active prodrug.

Huang TL, Bacchi CJ, Kode NR, Zhang Q, Wang G, Yartlet N, Rattendi D, Londono I, Mazumder L, Vanden Eynde JJ, Mayence A, Donkor IO.

Int J Antimicrob Agents. 2007 Dec;30(6):555-61. Epub 2007 Oct 24.

PMID:
17920820
11.

Irreversible inhibition of S-adenosylmethionine decarboxylase of Trypanosoma brucei brucei by S-adenosylmethionine analogues.

Tekwani BL, Bacchi CJ, Secrist JA 3rd, Pegg AE.

Biochem Pharmacol. 1992 Sep 1;44(5):905-11.

PMID:
1530659
12.

Cure of Trypanosoma brucei brucei and Trypanosoma brucei rhodesiense infections in mice with an irreversible inhibitor of S-adenosylmethionine decarboxylase.

Bitonti AJ, Byers TL, Bush TL, Casara PJ, Bacchi CJ, Clarkson AB Jr, McCann PP, Sjoerdsma A.

Antimicrob Agents Chemother. 1990 Aug;34(8):1485-90.

13.

Cure of murine Trypanosoma brucei rhodesiense infections with an S-adenosylmethionine decarboxylase inhibitor.

Bacchi CJ, Nathan HC, Yarlett N, Goldberg B, McCann PP, Bitonti AJ, Sjoerdsma A.

Antimicrob Agents Chemother. 1992 Dec;36(12):2736-40.

14.

Trypanocidal activity of dicationic compounds related to pentamidine.

Donkor IO, Assefa H, Rattendi D, Lane S, Vargas M, Goldberg B, Bacchi C.

Eur J Med Chem. 2001 Jun;36(6):531-8.

PMID:
11525843
15.

New treatment option for second-stage African sleeping sickness: in vitro and in vivo efficacy of aza analogs of DB289.

Wenzler T, Boykin DW, Ismail MA, Hall JE, Tidwell RR, Brun R.

Antimicrob Agents Chemother. 2009 Oct;53(10):4185-92. doi: 10.1128/AAC.00225-09. Epub 2009 Jul 20.

16.

In vivo efficacies of 5'-methylthioadenosine analogs as trypanocides.

Bacchi CJ, Sanabria K, Spiess AJ, Vargas M, Marasco CJ Jr, Jimenez LM, Goldberg B, Sufrin JR.

Antimicrob Agents Chemother. 1997 Oct;41(10):2108-12.

17.
18.

Synthesis of a series of N6-substituted adenosines with activity against trypanosomatid parasites.

Link A, Heidler P, Kaiser M, Brun R.

Eur J Med Chem. 2009 Sep;44(9):3665-71. doi: 10.1016/j.ejmech.2009.02.010. Epub 2009 Feb 20.

PMID:
19285758
19.

Metabolic effects of a methylthioadenosine phosphorylase substrate analog on African trypanosomes.

Bacchi CJ, Goldberg B, Rattendi D, Gorrell TE, Spiess AJ, Sufrin JR.

Biochem Pharmacol. 1999 Jan 1;57(1):89-96.

PMID:
9920289
20.

Regulation and function of polyamines in African trypanosomes.

Willert E, Phillips MA.

Trends Parasitol. 2012 Feb;28(2):66-72. doi: 10.1016/j.pt.2011.11.001. Epub 2011 Dec 20. Review.

PMID:
22192816

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