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19447184,24372552,25979821,17643323,16679034,20435152,17097307,15886026,24020938,23649000,22516473,19135537,17533421,17588780,19426820,19833140,32360993,30353374,17112502,19539041,15613131,11584331,26411977,20531221,11989578,18727453,33636421,18957528,12750037,25706450,21355918,18156612,16750469,12109926,8602374,8055145,18472280,15975832,17239713,19145580,11740632,21419854,19422925,17881416,15066127,23689033,22692379,12094149,18486227,10801251,23773986,11108180,27878411,19573731,12031065,17669094,17587605,16290300,28100427,12895193,21635956,21457682,16857392,29245320,19616107,23639348,22329611,30707117,18294569,21048421,27553432,16843688,7588899,16472283,11021469,16875971,32781158,17970959,26324176,29926671,25445869,34935398,9588657,24846924,10080424,17988441,12820821,30567462,19367688,8720305,28065822,25946685,15519906,22029876,27018992,19031039,11332559,16399550,17258913,11222883,30112668,9006298,18536754,20550968,17889568,24306340,27650425,15950495,29311442,25959881,32866317,30193085,20698854,18690968,29995258,22525003,16253927,28036334,32700358,34468739,27377419,32726229,20210719,28836822,11255387,11509917,9358509,36335640,25625756,16493187,12364811,25796102,15932797,25901446,16493189,27118261,25219539,11419561,19427912,24140388,17785940,25619672,21649448,19530746,30531476,8256757,10444240,22521338,9583450,26386326,30121123,8996300,10433382,29219167,16253926,28036330,15090000,18552873,27524478,22609158,31654357,9359544,25204465,16253928,18834945,31308302,26860921,26507917,15213787,12086546,19439186,19530747,20156577,30620510,9505930,28904293,15484154,27452340,26957141,17587601,18604237,25727282,20570743,15691222,34119674,19785646,28940299,24879942,26375169,8256753,16140023,34182121,26091641,12930510,35640715,15519904,18072173,34173339,20435149,26844408,27461785,21883384,14686224,10331827,16581270,18570170,10530807,20732434,20332033,29597013,28919218,12031064,19586616,16760695,16831559,35148401,29603015,19523527,17587603,33122341,27095299,19775279,16493192,17141531,14641790,30333366,11555327,33026317,12451707,22046106,1731461,37105125,30880152,33640634,15385084,23216298,11799844,24305646,16567113,23167578,11269621,18516073,16493193,26553352,29197146,27663457,23091201,30482568,25556117,25087057,26984445,21561039,20570745,21175443,9604234,29317399,36581147,23537164,29961858,22007855,10780196,12164254,20210723,9950644,33857614,29050844,24909270,7662454,26117457,20172034,33332579,34718206,20141519,16141657,16297641,36369797,29980434,23353637,22255166,15084215,15534789,22613062,18462188,16143547,25641747,23593245,27403002,36321834,20885008,11452340,26141494,15552544,17226051,26495337,15534790,20558308,35180813,20601020,17117723,12597426,28550094,25944685,12750039,32016923,20601019,26471025,21658459,26648606,25909335,21699823,22045830,15979349,29283067,34964507,32499095,32853262,37085406,32782861,30456871,22745218,15105210,34655760,19470407,26175009,27334640,27543323,16493190,31958651,25576068,29498300,28590366,29489066,21699874,27315379,9676722,19467337,31664592,25445020,26187237,20601021,9566444,28457157,22068668,35993620,21496166,28416413,20587168,25165548,29759542,27004702,34363962,28457161,36007862,25395252,15914033,34384200,26031452,36355743,34396315,24262389,29531576,26225204,35301126,9472751,22020456,30311557,18434212,18938261,36068182,23417505,32014539,19384499,34854829,26001324,12955618,16493191,19252337,17303921,9627074,30848818,21151384,27039258,28451647,33637137,29546612,7069332,29520534,406403,30366516,12058448,9530184,25246669,28643108,34513452,35771997,16945791,34010986,33321127,11230973,30214811,16428921,31428390,36352432,21762671,28363206,3689626,7213522,12540143,22126906,10197293,23802316,18417371,16011455,31545681,30414356,33470313,12596510,31255745,27392392,33708802,18332646,22936860,28358611,16943929,26091650,23849449,22275999,28458434,15702198,19165391,23579446,36116702,25080323,8140171,12623867,1290857,21822437,21564166,17970961,20735846,26028233,31006915,30167018,12841825,35173492,26952164,11800038,31586939,3712891,29060773,36001250,905375,36033635,31967582,34334315,21743615,16457537,30162746,28907753,29639862,29639844,28907221,30162991,24203253,29812042[uid]

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Measuring the risk of torsades de pointes: electrocardiographic evaluation of PNU-142093 in conscious cynomolgus non-human primates using restraint and non-restraint procedures.

Bass AS, Hanson LA, Jackson TA. Bass AS, et al. J Pharmacol Toxicol Methods. 2009 Jul-Aug;60(1):51-7. doi: 10.1016/j.vascn.2009.05.003. Epub 2009 May 14. J Pharmacol Toxicol Methods. 2009. PMID: 19447184

Detection of QTc interval prolongation using jacket telemetry in conscious non-human primates: comparison with implanted telemetry.

Derakhchan K, Chui RW, Stevens D, Gu W, Vargas HM. Derakhchan K, et al. Br J Pharmacol. 2014 Jan;171(2):509-22. doi: 10.1111/bph.12484. Br J Pharmacol. 2014. PMID: 24372552 Free PMC article.

Effects of group housing on ECG assessment in conscious cynomolgus monkeys.

Xing G, Lu J, Hu M, Wang S, Zhao L, Zheng W, Schofield J, Oldman K, Adkins D, Yu H, Platz S, Ren J, Skinner M. Xing G, et al. J Pharmacol Toxicol Methods. 2015 Sep-Oct;75:44-51. doi: 10.1016/j.vascn.2015.05.004. Epub 2015 May 12. J Pharmacol Toxicol Methods. 2015. PMID: 25979821

A highly sensitive canine telemetry model for detection of QT interval prolongation: studies with moxifloxacin, haloperidol and MK-499.

Chaves AA, Zingaro GJ, Yordy MA, Bustard KA, O'Sullivan S, Galijatovic-Idrizbegovic A, Schuck H, Christian DB, Hoe CM, Briscoe RJ. Chaves AA, et al. J Pharmacol Toxicol Methods. 2007 Sep-Oct;56(2):103-14. doi: 10.1016/j.vascn.2007.04.007. Epub 2007 May 24. J Pharmacol Toxicol Methods. 2007. PMID: 17643323

Cardiovascular monkey telemetry: sensitivity to detect QT interval prolongation.

Chaves AA, Keller WJ, O'Sullivan S, Williams MA, Fitzgerald LE, McPherson HE, Goykhman D, Ward PD, Hoe CM, Mixson L, Briscoe RJ. Chaves AA, et al. J Pharmacol Toxicol Methods. 2006 Sep-Oct;54(2):150-8. doi: 10.1016/j.vascn.2006.03.004. Epub 2006 Mar 27. J Pharmacol Toxicol Methods. 2006. PMID: 16679034

Uni- or bi-ventricular hypertrophy and susceptibility to drug-induced torsades de pointes.

Panyasing Y, Kijtawornrat A, Del Rio C, Carnes C, Hamlin RL. Panyasing Y, et al. J Pharmacol Toxicol Methods. 2010 Sep-Oct;62(2):148-56. doi: 10.1016/j.vascn.2010.04.007. Epub 2010 May 8. J Pharmacol Toxicol Methods. 2010. PMID: 20435152

Application of a probabilistic method for the determination of drug-induced QT prolongation in telemetered cynomolgus monkeys: effects of moxifloxacin.

Holzgrefe HH, Cavero I, Buchanan LV, Gill MW, Durham SK. Holzgrefe HH, et al. J Pharmacol Toxicol Methods. 2007 May-Jun;55(3):227-37. doi: 10.1016/j.vascn.2006.09.002. Epub 2006 Sep 15. J Pharmacol Toxicol Methods. 2007. PMID: 17097307

Correction of QT values to allow for increases in heart rate in conscious Beagle dogs in toxicology assessment.

Tattersall ML, Dymond M, Hammond T, Valentin JP. Tattersall ML, et al. J Pharmacol Toxicol Methods. 2006 Jan-Feb;53(1):11-9. doi: 10.1016/j.vascn.2005.02.005. J Pharmacol Toxicol Methods. 2006. PMID: 15886026

QT interval prolongation and the risk of torsades de pointes: essentials for clinicians.

Trinkley KE, Page RL 2nd, Lien H, Yamanouye K, Tisdale JE. Trinkley KE, et al. Curr Med Res Opin. 2013 Dec;29(12):1719-26. doi: 10.1185/03007995.2013.840568. Epub 2013 Sep 23. Curr Med Res Opin. 2013. PMID: 24020938 Review.

The anesthetized guinea pig: an effective early cardiovascular derisking and lead optimization model.

Morissette P, Nishida M, Trepakova E, Imredy J, Lagrutta A, Chaves A, Hoagland K, Hoe CM, Zrada MM, Travis JJ, Zingaro GJ, Gerenser P, Friedrichs G, Salata JJ. Morissette P, et al. J Pharmacol Toxicol Methods. 2013 Jul-Aug;68(1):137-49. doi: 10.1016/j.vascn.2013.04.010. Epub 2013 May 4. J Pharmacol Toxicol Methods. 2013. PMID: 23649000

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