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Items: 1 to 20 of 210

1.

A role of Gab2 association in Flt3 ITD mediated Stat5 phosphorylation and cell survival.

Masson K, Liu T, Khan R, Sun J, Rönnstrand L.

Br J Haematol. 2009 Jul;146(2):193-202. doi: 10.1111/j.1365-2141.2009.07725.x. Epub 2009 May 12.

PMID:
19438505
2.

Selective cytotoxic mechanism of GTP-14564, a novel tyrosine kinase inhibitor in leukemia cells expressing a constitutively active Fms-like tyrosine kinase 3 (FLT3).

Murata K, Kumagai H, Kawashima T, Tamitsu K, Irie M, Nakajima H, Suzu S, Shibuya M, Kamihira S, Nosaka T, Asano S, Kitamura T.

J Biol Chem. 2003 Aug 29;278(35):32892-8. Epub 2003 Jun 18.

3.

Overexpression and constitutive activation of FLT3 induces STAT5 activation in primary acute myeloid leukemia blast cells.

Spiekermann K, Bagrintseva K, Schwab R, Schmieja K, Hiddemann W.

Clin Cancer Res. 2003 Jun;9(6):2140-50.

4.

FLT3-ITD expression levels and their effect on STAT5 in AML with and without NPM mutations.

Seedhouse CH, Pallis M, Grundy M, Shang S, Russell NH.

Br J Haematol. 2009 Dec;147(5):653-61. doi: 10.1111/j.1365-2141.2009.07901.x. Epub 2009 Sep 22.

PMID:
19775300
5.

ITD- and FL-induced FLT3 signal transduction leads to increased C/EBPbeta-LIP expression and LIP/LAP ratio by different signalling modules.

Haas SC, Huber R, Gutsch R, Kandemir JD, Cappello C, Krauter J, Duyster J, Ganser A, Brand K.

Br J Haematol. 2010 Mar;148(5):777-90. doi: 10.1111/j.1365-2141.2009.08012.x. Epub 2009 Dec 1.

PMID:
19958352
6.

FLT3/ITD mutation signaling includes suppression of SHP-1.

Chen P, Levis M, Brown P, Kim KT, Allebach J, Small D.

J Biol Chem. 2005 Feb 18;280(7):5361-9. Epub 2004 Dec 1.

7.

FLT3 signals via the adapter protein Grb10 and overexpression of Grb10 leads to aberrant cell proliferation in acute myeloid leukemia.

Kazi JU, Rönnstrand L.

Mol Oncol. 2013 Jun;7(3):402-18. doi: 10.1016/j.molonc.2012.11.003. Epub 2012 Nov 29.

8.

[Mutations of growth factor receptor Flt3 in acute myeloid leukemia: transformation of myeloid cells by Ras-dependent and Ras-independent mechanisms].

Müller-Tidow C, Steur C, Mizuki M, Schwäble J, Brandts C, Berdel WE, Serve H.

Dtsch Med Wochenschr. 2002 Oct 18;127(42):2195-200. German.

PMID:
12397548
9.

FLT3/ITD expression increases expansion, survival and entry into cell cycle of human haematopoietic stem/progenitor cells.

Li L, Piloto O, Kim KT, Ye Z, Nguyen HB, Yu X, Levis M, Cheng L, Small D.

Br J Haematol. 2007 Apr;137(1):64-75.

PMID:
17359372
10.

Flt3 mutations from patients with acute myeloid leukemia induce transformation of 32D cells mediated by the Ras and STAT5 pathways.

Mizuki M, Fenski R, Halfter H, Matsumura I, Schmidt R, Müller C, Grüning W, Kratz-Albers K, Serve S, Steur C, Büchner T, Kienast J, Kanakura Y, Berdel WE, Serve H.

Blood. 2000 Dec 1;96(12):3907-14.

11.

FLT3/ ITD regulates leukaemia cell adhesion through α4β1 integrin and Pyk2 signalling.

Katsumi A, Kiyoi H, Abe A, Tanizaki R, Iwasaki T, Kobayashi M, Matsushita T, Kaibuchi K, Senga T, Kojima T, Kohno T, Hamaguchi M, Naoe T.

Eur J Haematol. 2011 Mar;86(3):191-8. doi: 10.1111/j.1600-0609.2010.01556.x. Epub 2011 Jan 25.

PMID:
21114537
12.

SRC is a signaling mediator in FLT3-ITD- but not in FLT3-TKD-positive AML.

Leischner H, Albers C, Grundler R, Razumovskaya E, Spiekermann K, Bohlander S, Rönnstrand L, Götze K, Peschel C, Duyster J.

Blood. 2012 Apr 26;119(17):4026-33. doi: 10.1182/blood-2011-07-365726. Epub 2012 Mar 12.

13.
14.

Constitutively activated FLT3 phosphorylates BAD partially through pim-1.

Kim KT, Levis M, Small D.

Br J Haematol. 2006 Sep;134(5):500-9.

PMID:
16869825
15.

Transformation by oncogenic mutants and ligand-dependent activation of FLT3 wild-type requires the tyrosine residues 589 and 591.

Vempati S, Reindl C, Wolf U, Kern R, Petropoulos K, Naidu VM, Buske C, Hiddemann W, Kohl TM, Spiekermann K.

Clin Cancer Res. 2008 Jul 15;14(14):4437-45. doi: 10.1158/1078-0432.CCR-07-1873.

16.

MS-275, a novel histone deacetylase inhibitor with selectivity against HDAC1, induces degradation of FLT3 via inhibition of chaperone function of heat shock protein 90 in AML cells.

Nishioka C, Ikezoe T, Yang J, Takeuchi S, Koeffler HP, Yokoyama A.

Leuk Res. 2008 Sep;32(9):1382-92. doi: 10.1016/j.leukres.2008.02.018. Epub 2008 Apr 3.

PMID:
18394702
17.

Constitutive activation of Flt3 and STAT5A enhances self-renewal and alters differentiation of hematopoietic stem cells.

Moore MA, Dorn DC, Schuringa JJ, Chung KY, Morrone G.

Exp Hematol. 2007 Apr;35(4 Suppl 1):105-16.

PMID:
17379095
18.

Anchoring of FLT3 in the endoplasmic reticulum alters signaling quality.

Schmidt-Arras D, Böhmer SA, Koch S, Müller JP, Blei L, Cornils H, Bauer R, Korasikha S, Thiede C, Böhmer FD.

Blood. 2009 Apr 9;113(15):3568-76. doi: 10.1182/blood-2007-10-121426. Epub 2009 Feb 9.

19.

FLT3 mutations in acute myeloid leukemia cell lines.

Quentmeier H, Reinhardt J, Zaborski M, Drexler HG.

Leukemia. 2003 Jan;17(1):120-4.

PMID:
12529668
20.

Roles of tyrosine 589 and 591 in STAT5 activation and transformation mediated by FLT3-ITD.

Rocnik JL, Okabe R, Yu JC, Lee BH, Giese N, Schenkein DP, Gilliland DG.

Blood. 2006 Aug 15;108(4):1339-45. Epub 2006 Apr 20.

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