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Regulation of ErbB2 receptor status by the proteasomal DUB POH1.

Liu H, Buus R, Clague MJ, Urbé S.

PLoS One. 2009;4(5):e5544. doi: 10.1371/journal.pone.0005544. Epub 2009 May 14.


Knockdown of human deubiquitinase PSMD14 induces cell cycle arrest and senescence.

Byrne A, McLaren RP, Mason P, Chai L, Dufault MR, Huang Y, Liang B, Gans JD, Zhang M, Carter K, Gladysheva TB, Teicher BA, Biemann HP, Booker M, Goldberg MA, Klinger KW, Lillie J, Madden SL, Jiang Y.

Exp Cell Res. 2010 Jan 15;316(2):258-71. doi: 10.1016/j.yexcr.2009.08.018. Epub 2009 Sep 2.


The JAMM motif of human deubiquitinase Poh1 is essential for cell viability.

Gallery M, Blank JL, Lin Y, Gutierrez JA, Pulido JC, Rappoli D, Badola S, Rolfe M, Macbeth KJ.

Mol Cancer Ther. 2007 Jan;6(1):262-8.


Attenuation of the ubiquitin conjugate DNA damage signal by the proteasomal DUB POH1.

Morris JR.

Cell Cycle. 2012 Nov 15;11(22):4103-4. doi: 10.4161/cc.22395. Epub 2012 Oct 17. No abstract available.


Geldanamycin-induced down-regulation of ErbB2 from the plasma membrane is clathrin dependent but proteasomal activity independent.

Pedersen NM, Madshus IH, Haslekås C, Stang E.

Mol Cancer Res. 2008 Mar;6(3):491-500. doi: 10.1158/1541-7786.MCR-07-0191.


ErbB2 trafficking and degradation associated with K48 and K63 polyubiquitination.

Marx C, Held JM, Gibson BW, Benz CC.

Cancer Res. 2010 May 1;70(9):3709-17. doi: 10.1158/0008-5472.CAN-09-3768. Epub 2010 Apr 20.


The proteasomal de-ubiquitinating enzyme POH1 promotes the double-strand DNA break response.

Butler LR, Densham RM, Jia J, Garvin AJ, Stone HR, Shah V, Weekes D, Festy F, Beesley J, Morris JR.

EMBO J. 2012 Oct 3;31(19):3918-34. doi: 10.1038/emboj.2012.232. Epub 2012 Aug 21.


AMSH is an endosome-associated ubiquitin isopeptidase.

McCullough J, Clague MJ, Urbé S.

J Cell Biol. 2004 Aug 16;166(4):487-92.


Chaperone-mediated 26S proteasome remodeling facilitates free K63 ubiquitin chain production and aggresome clearance.

Nanduri P, Hao R, Fitzpatrick T, Yao TP.

J Biol Chem. 2015 Apr 10;290(15):9455-64. doi: 10.1074/jbc.M114.627950. Epub 2015 Feb 24.


Co-operation of BRCA1 and POH1 relieves the barriers posed by 53BP1 and RAP80 to resection.

Kakarougkas A, Ismail A, Katsuki Y, Freire R, Shibata A, Jeggo PA.

Nucleic Acids Res. 2013 Dec;41(22):10298-311. doi: 10.1093/nar/gkt802. Epub 2013 Sep 5.


Cap-dependent mRNA translation and the ubiquitin-proteasome system cooperate to promote ERBB2-dependent esophageal cancer phenotype.

Issaenko OA, Bitterman PB, Polunovsky VA, Dahlberg PS.

Cancer Gene Ther. 2012 Sep;19(9):609-18. doi: 10.1038/cgt.2012.39. Epub 2012 Jul 6.


The deubiquitinating enzyme Usp14 allosterically inhibits multiple proteasomal activities and ubiquitin-independent proteolysis.

Kim HT, Goldberg AL.

J Biol Chem. 2017 Jun 9;292(23):9830-9839. doi: 10.1074/jbc.M116.763128. Epub 2017 Apr 17.


K63-specific deubiquitination by two JAMM/MPN+ complexes: BRISC-associated Brcc36 and proteasomal Poh1.

Cooper EM, Cutcliffe C, Kristiansen TZ, Pandey A, Pickart CM, Cohen RE.

EMBO J. 2009 Mar 18;28(6):621-31. doi: 10.1038/emboj.2009.27. Epub 2009 Feb 12.


Identification of an HSP90 modulated multi-step process for ERBB2 degradation in breast cancer cells.

Castagnola P, Bellese G, Birocchi F, Gagliani MC, Tacchetti C, Cortese K.

Oncotarget. 2016 Dec 20;7(51):85411-85429. doi: 10.18632/oncotarget.13392.


Pertuzumab increases epidermal growth factor receptor down-regulation by counteracting epidermal growth factor receptor-ErbB2 heterodimerization.

Hughes JB, Berger C, Rødland MS, Hasmann M, Stang E, Madshus IH.

Mol Cancer Ther. 2009 Jul;8(7):1885-92. doi: 10.1158/1535-7163.MCT-09-0291. Epub 2009 Jul 7.


Expression of epidermal growth factor receptor or ErbB3 facilitates geldanamycin-induced down-regulation of ErbB2.

Pedersen NM, Breen K, Rødland MS, Haslekås C, Stang E, Madshus IH.

Mol Cancer Res. 2009 Feb;7(2):275-84. doi: 10.1158/1541-7786.MCR-07-2183. Epub 2009 Feb 10.


Curcumin-induced degradation of ErbB2: A role for the E3 ubiquitin ligase CHIP and the Michael reaction acceptor activity of curcumin.

Jung Y, Xu W, Kim H, Ha N, Neckers L.

Biochim Biophys Acta. 2007 Mar;1773(3):383-90. Epub 2006 Nov 10.


ErbB2 degradation mediated by the co-chaperone protein CHIP.

Zhou P, Fernandes N, Dodge IL, Reddi AL, Rao N, Safran H, DiPetrillo TA, Wazer DE, Band V, Band H.

J Biol Chem. 2003 Apr 18;278(16):13829-37. Epub 2003 Feb 6.


Recycling of EGFR and ErbB2 is associated with impaired Hrs tyrosine phosphorylation and decreased deubiquitination by AMSH.

Meijer IM, van Rotterdam W, van Zoelen EJ, van Leeuwen JE.

Cell Signal. 2012 Nov;24(11):1981-8. doi: 10.1016/j.cellsig.2012.07.006. Epub 2012 Jul 16.


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