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Physiological functions of the HECT family of ubiquitin ligases.

Rotin D, Kumar S.

Nat Rev Mol Cell Biol. 2009 Jun;10(6):398-409. doi: 10.1038/nrm2690. Epub 2009 May 13. Review.


Mechanism of ubiquitin ligation and lysine prioritization by a HECT E3.

Kamadurai HB, Qiu Y, Deng A, Harrison JS, Macdonald C, Actis M, Rodrigues P, Miller DJ, Souphron J, Lewis SM, Kurinov I, Fujii N, Hammel M, Piper R, Kuhlman B, Schulman BA.

Elife. 2013 Aug 8;2:e00828. doi: 10.7554/eLife.00828.


Calcium activates Nedd4 E3 ubiquitin ligases by releasing the C2 domain-mediated auto-inhibition.

Wang J, Peng Q, Lin Q, Childress C, Carey D, Yang W.

J Biol Chem. 2010 Apr 16;285(16):12279-88. doi: 10.1074/jbc.M109.086405. Epub 2010 Feb 19.


Structure of a ubiquitin-loaded HECT ligase reveals the molecular basis for catalytic priming.

Maspero E, Valentini E, Mari S, Cecatiello V, Soffientini P, Pasqualato S, Polo S.

Nat Struct Mol Biol. 2013 Jun;20(6):696-701. doi: 10.1038/nsmb.2566. Epub 2013 May 5.


ISG15 inhibits Nedd4 ubiquitin E3 activity and enhances the innate antiviral response.

Malakhova OA, Zhang DE.

J Biol Chem. 2008 Apr 4;283(14):8783-7. doi: 10.1074/jbc.C800030200. Epub 2008 Feb 20.


The ubiquitin-protein ligases Nedd4 and Nedd4-2 show similar ubiquitin-conjugating enzyme specificities.

Fotia AB, Cook DI, Kumar S.

Int J Biochem Cell Biol. 2006 Mar;38(3):472-9. Epub 2005 Nov 22.


Regulation of the RSP5 ubiquitin ligase by an intrinsic ubiquitin-binding site.

French ME, Kretzmann BR, Hicke L.

J Biol Chem. 2009 May 1;284(18):12071-9. doi: 10.1074/jbc.M901106200. Epub 2009 Feb 27.


Nedd4 and Nedd4-2: closely related ubiquitin-protein ligases with distinct physiological functions.

Yang B, Kumar S.

Cell Death Differ. 2010 Jan;17(1):68-77. doi: 10.1038/cdd.2009.84. Review.


Physical interaction between specific E2 and Hect E3 enzymes determines functional cooperativity.

Kumar S, Kao WH, Howley PM.

J Biol Chem. 1997 May 23;272(21):13548-54.


Targeting HECT-type E3 ligases - insights from catalysis, regulation and inhibitors.

Fajner V, Maspero E, Polo S.

FEBS Lett. 2017 Sep;591(17):2636-2647. doi: 10.1002/1873-3468.12775. Epub 2017 Aug 20. Review.


Structure of the HHARI catalytic domain shows glimpses of a HECT E3 ligase.

Spratt DE, Mercier P, Shaw GS.

PLoS One. 2013 Aug 15;8(8):e74047. doi: 10.1371/journal.pone.0074047. eCollection 2013.


Ubiquitin-Activated Interaction Traps (UBAITs) identify E3 ligase binding partners.

O'Connor HF, Lyon N, Leung JW, Agarwal P, Swaim CD, Miller KM, Huibregtse JM.

EMBO Rep. 2015 Dec;16(12):1699-712. doi: 10.15252/embr.201540620. Epub 2015 Oct 27.


Rescue of HIV-1 release by targeting widely divergent NEDD4-type ubiquitin ligases and isolated catalytic HECT domains to Gag.

Weiss ER, Popova E, Yamanaka H, Kim HC, Huibregtse JM, G├Âttlinger H.

PLoS Pathog. 2010 Sep 16;6(9):e1001107. doi: 10.1371/journal.ppat.1001107.


Itch WW Domains Inhibit Its E3 Ubiquitin Ligase Activity by Blocking E2-E3 Ligase Trans-thiolation.

Riling C, Kamadurai H, Kumar S, O'Leary CE, Wu KP, Manion EE, Ying M, Schulman BA, Oliver PM.

J Biol Chem. 2015 Sep 25;290(39):23875-87. doi: 10.1074/jbc.M115.649269. Epub 2015 Aug 5.


HECT E3 ubiquitin ligase Nedd4-1 ubiquitinates ACK and regulates epidermal growth factor (EGF)-induced degradation of EGF receptor and ACK.

Lin Q, Wang J, Childress C, Sudol M, Carey DJ, Yang W.

Mol Cell Biol. 2010 Mar;30(6):1541-54. doi: 10.1128/MCB.00013-10. Epub 2010 Jan 19.


Control of the dynamics and homeostasis of the Drosophila Hedgehog receptor Patched by two C2-WW-HECT-E3 Ubiquitin ligases.

Brigui A, Hofmann L, Arg├╝elles C, Sanial M, Holmgren RA, Plessis A.

Open Biol. 2015 Oct;5(10). pii: 150112. doi: 10.1098/rsob.150112.


Down-regulation of intestinal apical calcium entry channel TRPV6 by ubiquitin E3 ligase Nedd4-2.

Zhang W, Na T, Wu G, Jing H, Peng JB.

J Biol Chem. 2010 Nov 19;285(47):36586-96. doi: 10.1074/jbc.M110.175968. Epub 2010 Sep 15.


The essential Ubc4/Ubc5 function in yeast is HECT E3-dependent, and RING E3-dependent pathways require only monoubiquitin transfer by Ubc4.

Stoll KE, Brzovic PS, Davis TN, Klevit RE.

J Biol Chem. 2011 Apr 29;286(17):15165-70. doi: 10.1074/jbc.M110.203968. Epub 2011 Feb 25.


HECT domain-containing E3 ubiquitin ligase Nedd4 interacts with and ubiquitinates Sprouty2.

Edwin F, Anderson K, Patel TB.

J Biol Chem. 2010 Jan 1;285(1):255-64. doi: 10.1074/jbc.M109.030882. Epub 2009 Oct 28.


Down-regulating destruction: phosphorylation regulates the E3 ubiquitin ligase Nedd4-2.

Snyder PM.

Sci Signal. 2009 Jul 14;2(79):pe41. doi: 10.1126/scisignal.279pe41. Review.


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