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Items: 1 to 20 of 152

1.

The Pks13/FadD32 crosstalk for the biosynthesis of mycolic acids in Mycobacterium tuberculosis.

Gavalda S, Léger M, van der Rest B, Stella A, Bardou F, Montrozier H, Chalut C, Burlet-Schiltz O, Marrakchi H, Daffé M, Quémard A.

J Biol Chem. 2009 Jul 17;284(29):19255-64. doi: 10.1074/jbc.M109.006940. Epub 2009 May 12.

2.

The dual function of the Mycobacterium tuberculosis FadD32 required for mycolic acid biosynthesis.

Léger M, Gavalda S, Guillet V, van der Rest B, Slama N, Montrozier H, Mourey L, Quémard A, Daffé M, Marrakchi H.

Chem Biol. 2009 May 29;16(5):510-9. doi: 10.1016/j.chembiol.2009.03.012.

3.
4.

Ser/Thr Phosphorylation Regulates the Fatty Acyl-AMP Ligase Activity of FadD32, an Essential Enzyme in Mycolic Acid Biosynthesis.

Le NH, Molle V, Eynard N, Miras M, Stella A, Bardou F, Galandrin S, Guillet V, André-Leroux G, Bellinzoni M, Alzari P, Mourey L, Burlet-Schiltz O, Daffé M, Marrakchi H.

J Biol Chem. 2016 Oct 21;291(43):22793-22805. Epub 2016 Sep 2.

PMID:
27590338
5.

The biosynthesis of mycolic acids in Mycobacterium tuberculosis relies on multiple specialized elongation complexes interconnected by specific protein-protein interactions.

Veyron-Churlet R, Bigot S, Guerrini O, Verdoux S, Malaga W, Daffé M, Zerbib D.

J Mol Biol. 2005 Nov 4;353(4):847-58. Epub 2005 Sep 23.

PMID:
16213523
6.

Purification and biochemical characterization of the Mycobacterium tuberculosis beta-ketoacyl-acyl carrier protein synthases KasA and KasB.

Schaeffer ML, Agnihotri G, Volker C, Kallender H, Brennan PJ, Lonsdale JT.

J Biol Chem. 2001 Dec 14;276(50):47029-37. Epub 2001 Oct 12.

7.

Acyl-CoA carboxylases (accD2 and accD3), together with a unique polyketide synthase (Cg-pks), are key to mycolic acid biosynthesis in Corynebacterianeae such as Corynebacterium glutamicum and Mycobacterium tuberculosis.

Gande R, Gibson KJ, Brown AK, Krumbach K, Dover LG, Sahm H, Shioyama S, Oikawa T, Besra GS, Eggeling L.

J Biol Chem. 2004 Oct 22;279(43):44847-57. Epub 2004 Aug 11.

8.

Antituberculosis thiophenes define a requirement for Pks13 in mycolic acid biosynthesis.

Wilson R, Kumar P, Parashar V, Vilchèze C, Veyron-Churlet R, Freundlich JS, Barnes SW, Walker JR, Szymonifka MJ, Marchiano E, Shenai S, Colangeli R, Jacobs WR Jr, Neiditch MB, Kremer L, Alland D.

Nat Chem Biol. 2013 Aug;9(8):499-506. doi: 10.1038/nchembio.1277. Epub 2013 Jun 16.

9.

Expression and characterization of polyketide synthase module involved in the late step of cephabacin biosynthesis from Lysobacter lactamgenus.

Lee JS, Vladimirova MG, Demirev AV, Kim BG, Lim SK, Nam DH.

J Microbiol Biotechnol. 2008 Mar;18(3):427-33.

10.

Crystal structure of the Mycobacterium tuberculosis beta-ketoacyl-acyl carrier protein synthase III.

Scarsdale JN, Kazanina G, He X, Reynolds KA, Wright HT.

J Biol Chem. 2001 Jun 8;276(23):20516-22. Epub 2001 Mar 8.

11.

The Mycobacterium tuberculosis beta-ketoacyl-acyl carrier protein synthase III activity is inhibited by phosphorylation on a single threonine residue.

Veyron-Churlet R, Molle V, Taylor RC, Brown AK, Besra GS, Zanella-Cléon I, Fütterer K, Kremer L.

J Biol Chem. 2009 Mar 6;284(10):6414-24. doi: 10.1074/jbc.M806537200. Epub 2008 Dec 11.

12.

The missing piece of the type II fatty acid synthase system from Mycobacterium tuberculosis.

Sacco E, Covarrubias AS, O'Hare HM, Carroll P, Eynard N, Jones TA, Parish T, Daffé M, Bäckbro K, Quémard A.

Proc Natl Acad Sci U S A. 2007 Sep 11;104(37):14628-33. Epub 2007 Sep 5.

13.

The polyketide synthase Pks13 catalyzes a novel mechanism of lipid transfer in mycobacteria.

Gavalda S, Bardou F, Laval F, Bon C, Malaga W, Chalut C, Guilhot C, Mourey L, Daffé M, Quémard A.

Chem Biol. 2014 Dec 18;21(12):1660-9. doi: 10.1016/j.chembiol.2014.10.011. Epub 2014 Nov 26.

14.

Biochemical and structural study of the atypical acyltransferase domain from the mycobacterial polyketide synthase Pks13.

Bergeret F, Gavalda S, Chalut C, Malaga W, Quémard A, Pedelacq JD, Daffé M, Guilhot C, Mourey L, Bon C.

J Biol Chem. 2012 Sep 28;287(40):33675-90. Epub 2012 Jul 23.

15.

Ability of Streptomyces spp. acyl carrier proteins and coenzyme A analogs to serve as substrates in vitro for E. coli holo-ACP synthase.

Gehring AM, Lambalot RH, Vogel KW, Drueckhammer DG, Walsh CT.

Chem Biol. 1997 Jan;4(1):17-24.

PMID:
9070424
16.

A polyketide synthase catalyzes the last condensation step of mycolic acid biosynthesis in mycobacteria and related organisms.

Portevin D, De Sousa-D'Auria C, Houssin C, Grimaldi C, Chami M, Daffé M, Guilhot C.

Proc Natl Acad Sci U S A. 2004 Jan 6;101(1):314-9. Epub 2003 Dec 26.

17.

AcpM, the meromycolate extension acyl carrier protein of Mycobacterium tuberculosis, is activated by the 4'-phosphopantetheinyl transferase PptT, a potential target of the multistep mycolic acid biosynthesis.

Zimhony O, Schwarz A, Raitses-Gurevich M, Peleg Y, Dym O, Albeck S, Burstein Y, Shakked Z.

Biochemistry. 2015 Apr 14;54(14):2360-71. doi: 10.1021/bi501444e. Epub 2015 Apr 1.

PMID:
25785780
18.
19.

Chain initiation on type I modular polyketide synthases revealed by limited proteolysis and ion-trap mass spectrometry.

Hong H, Appleyard AN, Siskos AP, Garcia-Bernardo J, Staunton J, Leadlay PF.

FEBS J. 2005 May;272(10):2373-87.

20.

Pathway to synthesis and processing of mycolic acids in Mycobacterium tuberculosis.

Takayama K, Wang C, Besra GS.

Clin Microbiol Rev. 2005 Jan;18(1):81-101. Review.

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