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Central role of ceramide biosynthesis in body weight regulation, energy metabolism, and the metabolic syndrome.

Yang G, Badeanlou L, Bielawski J, Roberts AJ, Hannun YA, Samad F.

Am J Physiol Endocrinol Metab. 2009 Jul;297(1):E211-24. doi: 10.1152/ajpendo.91014.2008. Epub 2009 May 12.


Inhibition of de novo ceramide synthesis reverses diet-induced insulin resistance and enhances whole-body oxygen consumption.

Ussher JR, Koves TR, Cadete VJ, Zhang L, Jaswal JS, Swyrd SJ, Lopaschuk DG, Proctor SD, Keung W, Muoio DM, Lopaschuk GD.

Diabetes. 2010 Oct;59(10):2453-64. doi: 10.2337/db09-1293. Epub 2010 Jun 3.


Hepatic cannabinoid-1 receptors mediate diet-induced insulin resistance by increasing de novo synthesis of long-chain ceramides.

Cinar R, Godlewski G, Liu J, Tam J, Jourdan T, Mukhopadhyay B, Harvey-White J, Kunos G.

Hepatology. 2014 Jan;59(1):143-53. doi: 10.1002/hep.26606. Epub 2013 Nov 18.


Inhibition of ceramide de novo synthesis reduces liver lipid accumulation in rats with nonalcoholic fatty liver disease.

Kurek K, Piotrowska DM, Wiesiołek-Kurek P, Łukaszuk B, Chabowski A, Górski J, Zendzian-Piotrowska M.

Liver Int. 2014 Aug;34(7):1074-83. doi: 10.1111/liv.12331. Epub 2013 Oct 16.


Adipose tissue and ceramide biosynthesis in the pathogenesis of obesity.

Samad F, Badeanlou L, Shah C, Yang G.

Adv Exp Med Biol. 2011;721:67-86. doi: 10.1007/978-1-4614-0650-1_5. Review.


Involvement of de novo ceramide synthesis in pro-inflammatory adipokine secretion and adipocyte-macrophage interaction.

Hamada Y, Nagasaki H, Fujiya A, Seino Y, Shang QL, Suzuki T, Hashimoto H, Oiso Y.

J Nutr Biochem. 2014 Dec;25(12):1309-16. doi: 10.1016/j.jnutbio.2014.07.008. Epub 2014 Sep 19.


Protection from high fat diet-induced increase in ceramide in mice lacking plasminogen activator inhibitor 1.

Shah C, Yang G, Lee I, Bielawski J, Hannun YA, Samad F.

J Biol Chem. 2008 May 16;283(20):13538-48. doi: 10.1074/jbc.M709950200. Epub 2008 Mar 22.


Inhibition of Ceramide De Novo Synthesis Ameliorates Diet Induced Skeletal Muscles Insulin Resistance.

Kurek K, Mikłosz A, Łukaszuk B, Chabowski A, Górski J, Żendzian-Piotrowska M.

J Diabetes Res. 2015;2015:154762. doi: 10.1155/2015/154762. Epub 2015 Aug 25.


Central infusion of histamine reduces fat accumulation and upregulates UCP family in leptin-resistant obese mice.

Masaki T, Yoshimatsu H, Chiba S, Watanabe T, Sakata T.

Diabetes. 2001 Feb;50(2):376-84.


Inhibition of serine palmitoyl transferase I reduces cardiac ceramide levels and increases glycolysis rates following diet-induced insulin resistance.

Ussher JR, Folmes CD, Keung W, Fillmore N, Jaswal JS, Cadete VJ, Beker DL, Lam VH, Zhang L, Lopaschuk GD.

PLoS One. 2012;7(5):e37703. doi: 10.1371/journal.pone.0037703. Epub 2012 May 22.


Role of sphingolipid mediator ceramide in obesity and renal injury in mice fed a high-fat diet.

Boini KM, Zhang C, Xia M, Poklis JL, Li PL.

J Pharmacol Exp Ther. 2010 Sep 1;334(3):839-46. doi: 10.1124/jpet.110.168815. Epub 2010 Jun 11.


Inhibition of sphingolipid synthesis improves dyslipidemia in the diet-induced hamster model of insulin resistance: evidence for the role of sphingosine and sphinganine in hepatic VLDL-apoB100 overproduction.

Dekker MJ, Baker C, Naples M, Samsoondar J, Zhang R, Qiu W, Sacco J, Adeli K.

Atherosclerosis. 2013 May;228(1):98-109. doi: 10.1016/j.atherosclerosis.2013.01.041. Epub 2013 Feb 10.


Increased adipose expression of the uncoupling protein-3 gene by thiazolidinediones in Wistar fatty rats and in cultured adipocytes.

Matsuda J, Hosoda K, Itoh H, Son C, Doi K, Hanaoka I, Inoue G, Nishimura H, Yoshimasa Y, Yamori Y, Odaka H, Nakao K.

Diabetes. 1998 Nov;47(11):1809-14.


Ceramide Synthase 5 Is Essential to Maintain C16:0-Ceramide Pools and Contributes to the Development of Diet-induced Obesity.

Gosejacob D, Jäger PS, Vom Dorp K, Frejno M, Carstensen AC, Köhnke M, Degen J, Dörmann P, Hoch M.

J Biol Chem. 2016 Mar 25;291(13):6989-7003. doi: 10.1074/jbc.M115.691212. Epub 2016 Feb 7.


Leptin intake during the suckling period improves the metabolic response of adipose tissue to a high-fat diet.

Priego T, Sánchez J, Palou A, Picó C.

Int J Obes (Lond). 2010 May;34(5):809-19. doi: 10.1038/ijo.2010.18. Epub 2010 Feb 16.


Roles for C16-ceramide and sphingosine 1-phosphate in regulating hepatocyte apoptosis in response to tumor necrosis factor-alpha.

Osawa Y, Uchinami H, Bielawski J, Schwabe RF, Hannun YA, Brenner DA.

J Biol Chem. 2005 Jul 29;280(30):27879-87. Epub 2005 Jun 9.


Induction of uncoupling protein expression in brown and white adipose tissue by leptin.

Commins SP, Watson PM, Padgett MA, Dudley A, Argyropoulos G, Gettys TW.

Endocrinology. 1999 Jan;140(1):292-300.


Carbenoxolone treatment ameliorated metabolic syndrome in WNIN/Ob obese rats, but induced severe fat loss and glucose intolerance in lean rats.

Prasad Sakamuri SS, Sukapaka M, Prathipati VK, Nemani H, Putcha UK, Pothana S, Koppala SR, Ponday LR, Acharya V, Veetill GN, Ayyalasomayajula V.

PLoS One. 2012;7(12):e50216. doi: 10.1371/journal.pone.0050216. Epub 2012 Dec 17.


Reduced energy expenditure and increased inflammation are early events in the development of ovariectomy-induced obesity.

Rogers NH, Perfield JW 2nd, Strissel KJ, Obin MS, Greenberg AS.

Endocrinology. 2009 May;150(5):2161-8. doi: 10.1210/en.2008-1405. Epub 2009 Jan 29.

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