Sort by
Items per page

Send to

Choose Destination

Links from PubMed

Items: 1 to 20 of 190


ARHI (DIRAS3), an imprinted tumour suppressor gene, binds to importins and blocks nuclear import of cargo proteins.

Huang S, Chang IS, Lin W, Ye W, Luo RZ, Lu Z, Lu Y, Zhang K, Liao WS, Tao T, Bast RC Jr, Chen X, Yu Y.

Biosci Rep. 2009 Dec 15;30(3):159-68. doi: 10.1042/BSR20090008.


Dynamics of the STAT3 transcription factor: nuclear import dependent on Ran and importin-β1.

Cimica V, Chen HC, Iyer JK, Reich NC.

PLoS One. 2011;6(5):e20188. doi: 10.1371/journal.pone.0020188. Epub 2011 May 19.


A Ras homologue member I directly inhibits signal transducers and activators of transcription 3 translocation and activity in human breast and ovarian cancer cells.

Nishimoto A, Yu Y, Lu Z, Mao X, Ren Z, Watowich SS, Mills GB, Liao WS, Chen X, Bast RC Jr, Luo RZ.

Cancer Res. 2005 Aug 1;65(15):6701-10.


Nuclear Respiratory Factor 2β (NRF-2β) recruits NRF-2α to the nucleus by binding to importin-α:β via an unusual monopartite-type nuclear localization signal.

Hayashi R, Takeuchi N, Ueda T.

J Mol Biol. 2013 Sep 23;425(18):3536-48. doi: 10.1016/j.jmb.2013.07.007. Epub 2013 Jul 13.


Characterization of the human herpesvirus 6 U69 gene product and identification of its nuclear localization signal.

Isegawa Y, Miyamoto Y, Yasuda Y, Semi K, Tsujimura K, Fukunaga R, Ohshima A, Horiguchi Y, Yoneda Y, Sugimoto N.

J Virol. 2008 Jan;82(2):710-8. Epub 2007 Nov 14.


RanBP3 contains an unusual nuclear localization signal that is imported preferentially by importin-alpha3.

Welch K, Franke J, Köhler M, Macara IG.

Mol Cell Biol. 1999 Dec;19(12):8400-11.


Stimulation of nuclear export and inhibition of nuclear import by a Ran mutant deficient in binding to Ran-binding protein 1.

Kehlenbach RH, Assheuer R, Kehlenbach A, Becker J, Gerace L.

J Biol Chem. 2001 Apr 27;276(17):14524-31. Epub 2001 Jan 30.


The tumor-suppressor gene ARHI (DIRAS3) suppresses ovarian cancer cell migration through inhibition of the Stat3 and FAK/Rho signaling pathways.

Badgwell DB, Lu Z, Le K, Gao F, Yang M, Suh GK, Bao JJ, Das P, Andreeff M, Chen W, Yu Y, Ahmed AA, S-L Liao W, Bast RC Jr.

Oncogene. 2012 Jan 5;31(1):68-79. doi: 10.1038/onc.2011.213. Epub 2011 Jun 6.


Characterization of nuclear import of the domain-specific androgen receptor in association with the importin alpha/beta and Ran-guanosine 5'-triphosphate systems.

Kaku N, Matsuda K, Tsujimura A, Kawata M.

Endocrinology. 2008 Aug;149(8):3960-9. doi: 10.1210/en.2008-0137. Epub 2008 Apr 17.


Nuclear localization signal and protein context both mediate importin alpha specificity of nuclear import substrates.

Friedrich B, Quensel C, Sommer T, Hartmann E, Köhler M.

Mol Cell Biol. 2006 Dec;26(23):8697-709. Epub 2006 Sep 25.


Inhibition of nuclear import by the proapoptotic protein CC3.

King FW, Shtivelman E.

Mol Cell Biol. 2004 Aug;24(16):7091-101.


Structural perspective of ARHI mediated inhibition of STAT3 signaling: an insight into the inactive to active transition of ARHI and its interaction with STAT3 and importinβ.

Muthu K, Panneerselvam M, Topno NS, Jayaraman M, Ramadas K.

Cell Signal. 2015 Apr;27(4):739-55. doi: 10.1016/j.cellsig.2014.11.036. Epub 2014 Dec 11.


Transcriptional and posttranscriptional down-regulation of the imprinted tumor suppressor gene ARHI (DRAS3) in ovarian cancer.

Lu Z, Luo RZ, Peng H, Rosen DG, Atkinson EN, Warneke C, Huang M, Nishmoto A, Liu J, Liao WS, Yu Y, Bast RC Jr.

Clin Cancer Res. 2006 Apr 15;12(8):2404-13.


A novel conserved nuclear localization signal is recognized by a group of yeast importins.

Fries T, Betz C, Sohn K, Caesar S, Schlenstedt G, Bailer SM.

J Biol Chem. 2007 Jul 6;282(27):19292-301. Epub 2007 May 7.


Biochemistry and biology of ARHI (DIRAS3), an imprinted tumor suppressor gene whose expression is lost in ovarian and breast cancers.

Yu Y, Luo R, Lu Z, Wei Feng W, Badgwell D, Issa JP, Rosen DG, Liu J, Bast RC Jr.

Methods Enzymol. 2006;407:455-68.


Supplemental Content

Support Center