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Mitogen-activated protein kinase phosphatase-1 in human breast cancer independently predicts prognosis and is repressed by doxorubicin.

Rojo F, González-Navarrete I, Bragado R, Dalmases A, Menéndez S, Cortes-Sempere M, Suárez C, Oliva C, Servitja S, Rodriguez-Fanjul V, Sánchez-Pérez I, Campas C, Corominas JM, Tusquets I, Bellosillo B, Serrano S, Perona R, Rovira A, Albanell J.

Clin Cancer Res. 2009 May 15;15(10):3530-9. doi: 10.1158/1078-0432.CCR-08-2070. Epub 2009 May 5.


Mitogen-activated protein kinase phosphatase-1 is overexpressed in non-small cell lung cancer and is an independent predictor of outcome in patients.

Vicent S, Garayoa M, López-Picazo JM, Lozano MD, Toledo G, Thunnissen FB, Manzano RG, Montuenga LM.

Clin Cancer Res. 2004 Jun 1;10(11):3639-49.


Docosahexaenoic acid induces apoptosis in lung cancer cells by increasing MKP-1 and down-regulating p-ERK1/2 and p-p38 expression.

Serini S, Trombino S, Oliva F, Piccioni E, Monego G, Resci F, Boninsegna A, Picci N, Ranelletti FO, Calviello G.

Apoptosis. 2008 Sep;13(9):1172-83. doi: 10.1007/s10495-008-0246-1.


Mitogen-activated protein kinase phosphatase-1 is a mediator of breast cancer chemoresistance.

Small GW, Shi YY, Higgins LS, Orlowski RZ.

Cancer Res. 2007 May 1;67(9):4459-66.


Mitogen-activated protein kinase phosphatase 1 is overexpressed in prostate cancers and is inversely related to apoptosis.

Magi-Galluzzi C, Mishra R, Fiorentino M, Montironi R, Yao H, Capodieci P, Wishnow K, Kaplan I, Stork PJ, Loda M.

Lab Invest. 1997 Jan;76(1):37-51.


Mitogen-activated protein kinase phosphatase-1 negatively regulates the expression of interleukin-6, interleukin-8, and cyclooxygenase-2 in A549 human lung epithelial cells.

Turpeinen T, Nieminen R, Moilanen E, Korhonen R.

J Pharmacol Exp Ther. 2010 Apr;333(1):310-8. doi: 10.1124/jpet.109.157438. Epub 2010 Jan 20.


Repression of mitogen-activated protein kinase (MAPK) phosphatase-1 by anthracyclines contributes to their antiapoptotic activation of p44/42-MAPK.

Small GW, Somasundaram S, Moore DT, Shi YY, Orlowski RZ.

J Pharmacol Exp Ther. 2003 Dec;307(3):861-9. Epub 2003 Oct 13.


KLF5 promotes breast cell survival partially through fibroblast growth factor-binding protein 1-pERK-mediated dual specificity MKP-1 protein phosphorylation and stabilization.

Liu R, Zheng HQ, Zhou Z, Dong JT, Chen C.

J Biol Chem. 2009 Jun 19;284(25):16791-8. doi: 10.1074/jbc.M808919200. Epub 2009 May 1.


Prognostic significance of phosphorylated P38 mitogen-activated protein kinase and HER-2 expression in lymph node-positive breast carcinoma.

Esteva FJ, Sahin AA, Smith TL, Yang Y, Pusztai L, Nahta R, Buchholz TA, Buzdar AU, Hortobagyi GN, Bacus SS.

Cancer. 2004 Feb 1;100(3):499-506.


The decrease in JNK- and p38-MAP kinase activity is accompanied by the enhancement of PP2A phosphate level in the brain of prenatally stressed rats.

Budziszewska B, Szymanska M, Leskiewicz M, Basta-Kaim A, Jaworska-Feil L, Kubera M, Jantas D, Lason W.

J Physiol Pharmacol. 2010 Apr;61(2):207-15.


Mitogen-activated protein kinase expression and activation does not differentiate benign from malignant mesothelial cells.

Vintman L, Nielsen S, Berner A, Reich R, Davidson B.

Cancer. 2005 Jun 1;103(11):2427-33.


Glutamine protects mice from lethal endotoxic shock via a rapid induction of MAPK phosphatase-1.

Ko HM, Oh SH, Bang HS, Kang NI, Cho BH, Im SY, Lee HK.

J Immunol. 2009 Jun 15;182(12):7957-62. doi: 10.4049/jimmunol.0900043.


Cell-specific activation profile of extracellular signal-regulated kinase 1/2, Jun N-terminal kinase, and p38 mitogen-activated protein kinases in asthmatic airways.

Liu W, Liang Q, Balzar S, Wenzel S, Gorska M, Alam R.

J Allergy Clin Immunol. 2008 Apr;121(4):893-902.e2. doi: 10.1016/j.jaci.2008.02.004.


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