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Items: 1 to 20 of 108

1.

Catalytically-active complex of HIV-1 integrase with a viral DNA substrate binds anti-integrase drugs.

Alian A, Griner SL, Chiang V, Tsiang M, Jones G, Birkus G, Geleziunas R, Leavitt AD, Stroud RM.

Proc Natl Acad Sci U S A. 2009 May 19;106(20):8192-7. doi: 10.1073/pnas.0811919106. Epub 2009 May 4.

2.

In vitro assays for activities of retroviral integrase.

Chow SA.

Methods. 1997 Aug;12(4):306-17.

PMID:
9245611
3.

Changes to the HIV long terminal repeat and to HIV integrase differentially impact HIV integrase assembly, activity, and the binding of strand transfer inhibitors.

Dicker IB, Samanta HK, Li Z, Hong Y, Tian Y, Banville J, Remillard RR, Walker MA, Langley DR, Krystal M.

J Biol Chem. 2007 Oct 26;282(43):31186-96. Epub 2007 Aug 21.

4.

Nucleoprotein complex intermediates in HIV-1 integration.

Li M, Craigie R.

Methods. 2009 Apr;47(4):237-42. doi: 10.1016/j.ymeth.2009.02.001. Epub 2009 Feb 20.

5.
6.

In search of second-generation HIV integrase inhibitors: targeting integration beyond strand transfer.

Voet AR, Maeyer MD, Debyser Z, Christ F.

Future Med Chem. 2009 Oct;1(7):1259-74. doi: 10.4155/fmc.09.86. Review.

PMID:
21426102
7.

HIV-1 integrase inhibitors that compete with the target DNA substrate define a unique strand transfer conformation for integrase.

Espeseth AS, Felock P, Wolfe A, Witmer M, Grobler J, Anthony N, Egbertson M, Melamed JY, Young S, Hamill T, Cole JL, Hazuda DJ.

Proc Natl Acad Sci U S A. 2000 Oct 10;97(21):11244-9.

8.

Resistance to HIV-1 integrase inhibitors: A structural perspective.

Mouscadet JF, Delelis O, Marcelin AG, Tchertanov L.

Drug Resist Updat. 2010 Aug-Oct;13(4-5):139-50. doi: 10.1016/j.drup.2010.05.001. Epub 2010 Jun 8. Review.

PMID:
20570551
9.

Biochemical analysis of HIV-1 integrase variants resistant to strand transfer inhibitors.

Dicker IB, Terry B, Lin Z, Li Z, Bollini S, Samanta HK, Gali V, Walker MA, Krystal MR.

J Biol Chem. 2008 Aug 29;283(35):23599-609. doi: 10.1074/jbc.M804213200. Epub 2008 Jun 24.

11.

Dihydroxythiophenes are novel potent inhibitors of human immunodeficiency virus integrase with a diketo acid-like pharmacophore.

Kehlenbeck S, Betz U, Birkmann A, Fast B, Göller AH, Henninger K, Lowinger T, Marrero D, Paessens A, Paulsen D, Pevzner V, Schohe-Loop R, Tsujishita H, Welker R, Kreuter J, Rübsamen-Waigmann H, Dittmer F.

J Virol. 2006 Jul;80(14):6883-94.

12.

Mode of interaction of G-quartets with the integrase of human immunodeficiency virus type 1.

Cherepanov P, Esté JA, Rando RF, Ojwang JO, Reekmans G, Steinfeld R, David G, De Clercq E, Debyser Z.

Mol Pharmacol. 1997 Nov;52(5):771-80.

13.

Activity of recombinant HIV-1 integrase on mini-HIV DNA.

Cherepanov P, Surratt D, Toelen J, Pluymers W, Griffith J, De Clercq E, Debyser Z.

Nucleic Acids Res. 1999 May 15;27(10):2202-10.

14.

Divalent cations stimulate preferential recognition of a viral DNA end by HIV-1 integrase.

Yi J, Asante-Appiah E, Skalka AM.

Biochemistry. 1999 Jun 29;38(26):8458-68.

PMID:
10387092
15.

Effect of DNA modifications on DNA processing by HIV-1 integrase and inhibitor binding: role of DNA backbone flexibility and an open catalytic site.

Johnson AA, Sayer JM, Yagi H, Patil SS, Debart F, Maier MA, Corey DR, Vasseur JJ, Burke TR Jr, Marquez VE, Jerina DM, Pommier Y.

J Biol Chem. 2006 Oct 27;281(43):32428-38. Epub 2006 Aug 30.

16.

Biochemical screening assays to identify HIV-1 integrase inhibitors.

Clynhens M, Smets A, Vereycken I, Van Loock M, Clayton R, Meersseman G, Goethals O.

Methods Mol Biol. 2013;1030:25-36. doi: 10.1007/978-1-62703-484-5_4.

PMID:
23821258
17.

Inhibitors of strand transfer that prevent integration and inhibit HIV-1 replication in cells.

Hazuda DJ, Felock P, Witmer M, Wolfe A, Stillmock K, Grobler JA, Espeseth A, Gabryelski L, Schleif W, Blau C, Miller MD.

Science. 2000 Jan 28;287(5453):646-50.

19.

Retroviral DNA integration: reaction pathway and critical intermediates.

Li M, Mizuuchi M, Burke TR Jr, Craigie R.

EMBO J. 2006 Mar 22;25(6):1295-304. Epub 2006 Feb 16.

20.

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