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Items: 1 to 20 of 418

1.

Roles of the receptor, the ligand, and the cell in the signal transduction pathways utilized by the relaxin family peptide receptors 1-3.

Summers RJ, Bathgate RA, Wade JD, van der Westhuizen ET, Halls ML.

Ann N Y Acad Sci. 2009 Apr;1160:99-104. doi: 10.1111/j.1749-6632.2009.03828.x.

PMID:
19416167
2.

Relaxin family peptide receptors RXFP1 and RXFP2 modulate cAMP signaling by distinct mechanisms.

Halls ML, Bathgate RA, Summers RJ.

Mol Pharmacol. 2006 Jul;70(1):214-26. Epub 2006 Mar 28.

3.

Comparison of signaling pathways activated by the relaxin family peptide receptors, RXFP1 and RXFP2, using reporter genes.

Halls ML, Bathgate RA, Summers RJ.

J Pharmacol Exp Ther. 2007 Jan;320(1):281-90. Epub 2006 Oct 25.

4.

Relaxin activates multiple cAMP signaling pathway profiles in different target cells.

Halls ML, Hewitson TD, Moore XL, Du XJ, Bathgate RA, Summers RJ.

Ann N Y Acad Sci. 2009 Apr;1160:108-11. doi: 10.1111/j.1749-6632.2008.03814.x.

PMID:
19416169
5.

H2 relaxin is a biased ligand relative to H3 relaxin at the relaxin family peptide receptor 3 (RXFP3).

van der Westhuizen ET, Christopoulos A, Sexton PM, Wade JD, Summers RJ.

Mol Pharmacol. 2010 May;77(5):759-72. doi: 10.1124/mol.109.061432. Epub 2010 Feb 16.

6.

Identification of the N-linked glycosylation sites of the human relaxin receptor and effect of glycosylation on receptor function.

Yan Y, Scott DJ, Wilkinson TN, Ji J, Tregear GW, Bathgate RA.

Biochemistry. 2008 Jul 1;47(26):6953-68. doi: 10.1021/bi800535b. Epub 2008 Jun 6.

PMID:
18533687
7.

International Union of Pharmacology LVII: recommendations for the nomenclature of receptors for relaxin family peptides.

Bathgate RA, Ivell R, Sanborn BM, Sherwood OD, Summers RJ.

Pharmacol Rev. 2006 Mar;58(1):7-31. Review.

9.

Relaxin family peptides and their receptors.

Bathgate RA, Halls ML, van der Westhuizen ET, Callander GE, Kocan M, Summers RJ.

Physiol Rev. 2013 Jan;93(1):405-80. doi: 10.1152/physrev.00001.2012. Review.

10.

Relaxin family peptide receptor (RXFP1) coupling to G(alpha)i3 involves the C-terminal Arg752 and localization within membrane Raft Microdomains.

Halls ML, van der Westhuizen ET, Wade JD, Evans BA, Bathgate RA, Summers RJ.

Mol Pharmacol. 2009 Feb;75(2):415-28. doi: 10.1124/mol.108.051227. Epub 2008 Nov 24.

11.

Receptors for relaxin family peptides.

Bathgate RA, Ivell R, Sanborn BM, Sherwood OD, Summers RJ.

Ann N Y Acad Sci. 2005 May;1041:61-76. Review.

PMID:
15956688
12.

Relaxin family peptide receptors--former orphans reunite with their parent ligands to activate multiple signalling pathways.

Halls ML, van der Westhuizen ET, Bathgate RA, Summers RJ.

Br J Pharmacol. 2007 Mar;150(6):677-91. Epub 2007 Feb 12. Review.

13.

The relaxin family peptide receptor 3 activates extracellular signal-regulated kinase 1/2 through a protein kinase C-dependent mechanism.

van der Westhuizen ET, Werry TD, Sexton PM, Summers RJ.

Mol Pharmacol. 2007 Jun;71(6):1618-29. Epub 2007 Mar 9.

14.

Mechanisms of relaxin receptor (LGR7/RXFP1) expression and function.

Kern A, Bryant-Greenwood GD.

Ann N Y Acad Sci. 2009 Apr;1160:60-6. doi: 10.1111/j.1749-6632.2008.03826.x.

PMID:
19416160
15.

RXFP1 couples to the Galpha-Gbetagamma-PI3K-PKCzeta pathway via the final 10 amino acids of the receptor C-terminal tail.

Halls ML, Papaioannou M, Wade JD, Evans BA, Bathgate RA, Summers RJ.

Ann N Y Acad Sci. 2009 Apr;1160:117-20. doi: 10.1111/j.1749-6632.2008.03813.x.

PMID:
19416171
16.

Multiple binding sites revealed by interaction of relaxin family peptides with native and chimeric relaxin family peptide receptors 1 and 2 (LGR7 and LGR8).

Halls ML, Bond CP, Sudo S, Kumagai J, Ferraro T, Layfield S, Bathgate RA, Summers RJ.

J Pharmacol Exp Ther. 2005 May;313(2):677-87. Epub 2005 Jan 12.

17.

Probing the functional domains of relaxin-3 and the creation of a selective antagonist for RXFP3/GPCR135 over relaxin receptor RXFP1/LGR7.

Liu C, Kuei C, Sutton S, Shelton J, Zhu J, Nepomuceno D, Hossain MA, Wade JD, Bathgate RA, Bonaventure P, Lovenberg T.

Ann N Y Acad Sci. 2009 Apr;1160:31-7. doi: 10.1111/j.1749-6632.2008.03790.x.

PMID:
19416155
18.

Membrane receptors: structure and function of the relaxin family peptide receptors.

Kong RC, Shilling PJ, Lobb DK, Gooley PR, Bathgate RA.

Mol Cell Endocrinol. 2010 May 14;320(1-2):1-15. doi: 10.1016/j.mce.2010.02.003. Epub 2010 Feb 6. Review.

PMID:
20138959
19.

The A-chain of human relaxin family peptides has distinct roles in the binding and activation of the different relaxin family peptide receptors.

Hossain MA, Rosengren KJ, Haugaard-J├Ânsson LM, Zhang S, Layfield S, Ferraro T, Daly NL, Tregear GW, Wade JD, Bathgate RA.

J Biol Chem. 2008 Jun 20;283(25):17287-97. doi: 10.1074/jbc.M801911200. Epub 2008 Apr 22.

20.

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