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Items: 1 to 20 of 98

1.

TAG, a splice variant of the adaptor TRAM, negatively regulates the adaptor MyD88-independent TLR4 pathway.

Palsson-McDermott EM, Doyle SL, McGettrick AF, Hardy M, Husebye H, Banahan K, Gong M, Golenbock D, Espevik T, O'Neill LA.

Nat Immunol. 2009 Jun;10(6):579-86. doi: 10.1038/ni.1727. Epub 2009 May 3.

PMID:
19412184
2.

The GOLD domain-containing protein TMED7 inhibits TLR4 signalling from the endosome upon LPS stimulation.

Doyle SL, Husebye H, Connolly DJ, Espevik T, O'Neill LA, McGettrick AF.

Nat Commun. 2012 Feb 28;3:707. doi: 10.1038/ncomms1706.

PMID:
22426228
3.

A role for the adaptor proteins TRAM and TRIF in toll-like receptor 2 signaling.

Nilsen NJ, Vladimer GI, Stenvik J, Orning MP, Zeid-Kilani MV, Bugge M, Bergstroem B, Conlon J, Husebye H, Hise AG, Fitzgerald KA, Espevik T, Lien E.

J Biol Chem. 2015 Feb 6;290(6):3209-22. doi: 10.1074/jbc.M114.593426. Epub 2014 Dec 11.

4.

LPS-TLR4 signaling to IRF-3/7 and NF-kappaB involves the toll adapters TRAM and TRIF.

Fitzgerald KA, Rowe DC, Barnes BJ, Caffrey DR, Visintin A, Latz E, Monks B, Pitha PM, Golenbock DT.

J Exp Med. 2003 Oct 6;198(7):1043-55. Epub 2003 Sep 29. Erratum in: J Exp Med. 2003 Nov 3;198(9):following 1450.

5.

Identification of a Regulatory Acidic Motif as the Determinant of Membrane Localization of TICAM-2.

Funami K, Matsumoto M, Enokizono Y, Ishii N, Tatematsu M, Oshiumi H, Inagaki F, Seya T.

J Immunol. 2015 Nov 1;195(9):4456-65. doi: 10.4049/jimmunol.1402628. Epub 2015 Sep 25.

6.

TRAM is required for TLR2 endosomal signaling to type I IFN induction.

Stack J, Doyle SL, Connolly DJ, Reinert LS, O'Keeffe KM, McLoughlin RM, Paludan SR, Bowie AG.

J Immunol. 2014 Dec 15;193(12):6090-102. doi: 10.4049/jimmunol.1401605. Epub 2014 Nov 10.

7.

CD14, TLR4 and TRAM Show Different Trafficking Dynamics During LPS Stimulation.

Klein DC, Skjesol A, Kers-Rebel ED, Sherstova T, Sporsheim B, Egeberg KW, Stokke BT, Espevik T, Husebye H.

Traffic. 2015 Jul;16(7):677-90. doi: 10.1111/tra.12274. Epub 2015 Mar 24.

8.

The small GTPase Arf6 is essential for the Tram/Trif pathway in TLR4 signaling.

Van Acker T, Eyckerman S, Vande Walle L, Gerlo S, Goethals M, Lamkanfi M, Bovijn C, Tavernier J, Peelman F.

J Biol Chem. 2014 Jan 17;289(3):1364-76. doi: 10.1074/jbc.M113.499194. Epub 2013 Dec 2.

9.

TRAM is involved in IL-18 signaling and functions as a sorting adaptor for MyD88.

Ohnishi H, Tochio H, Kato Z, Kawamoto N, Kimura T, Kubota K, Yamamoto T, Funasaka T, Nakano H, Wong RW, Shirakawa M, Kondo N.

PLoS One. 2012;7(6):e38423. doi: 10.1371/journal.pone.0038423. Epub 2012 Jun 7.

10.

Phosphatase PTPN4 preferentially inhibits TRIF-dependent TLR4 pathway by dephosphorylating TRAM.

Huai W, Song H, Wang L, Li B, Zhao J, Han L, Gao C, Jiang G, Zhang L, Zhao W.

J Immunol. 2015 May 1;194(9):4458-65. doi: 10.4049/jimmunol.1402183. Epub 2015 Mar 30.

11.

TIR-containing adapter molecule (TICAM)-2, a bridging adapter recruiting to toll-like receptor 4 TICAM-1 that induces interferon-beta.

Oshiumi H, Sasai M, Shida K, Fujita T, Matsumoto M, Seya T.

J Biol Chem. 2003 Dec 12;278(50):49751-62. Epub 2003 Sep 30.

12.

Inhibition of clathrin/dynamin-dependent internalization interferes with LPS-mediated TRAM-TRIF-dependent signaling pathway.

Wang Y, Yang Y, Liu X, Wang N, Cao H, Lu Y, Zhou H, Zheng J.

Cell Immunol. 2012;274(1-2):121-9. doi: 10.1016/j.cellimm.2011.12.007. Epub 2012 Jan 2.

PMID:
22341560
13.

Transforming growth factor-beta differentially inhibits MyD88-dependent, but not TRAM- and TRIF-dependent, lipopolysaccharide-induced TLR4 signaling.

Naiki Y, Michelsen KS, Zhang W, Chen S, Doherty TM, Arditi M.

J Biol Chem. 2005 Feb 18;280(7):5491-5. Epub 2004 Dec 28.

14.

Absence of TRAM restricts Toll-like receptor 4 signaling in vascular endothelial cells to the MyD88 pathway.

Harari OA, Alcaide P, Ahl D, Luscinskas FW, Liao JK.

Circ Res. 2006 May 12;98(9):1134-40. Epub 2006 Mar 30.

15.

Lysosome-associated small Rab GTPase Rab7b negatively regulates TLR4 signaling in macrophages by promoting lysosomal degradation of TLR4.

Wang Y, Chen T, Han C, He D, Liu H, An H, Cai Z, Cao X.

Blood. 2007 Aug 1;110(3):962-71. Epub 2007 Mar 29.

16.

Roles for LPS-dependent interaction and relocation of TLR4 and TRAM in TRIF-signaling.

Tanimura N, Saitoh S, Matsumoto F, Akashi-Takamura S, Miyake K.

Biochem Biophys Res Commun. 2008 Mar 28;368(1):94-9. doi: 10.1016/j.bbrc.2008.01.061. Epub 2008 Jan 28.

PMID:
18222170
17.

The TIR-domain containing adaptor TRAM is required for TLR7 mediated RANTES production.

Shevlin E, Miggin SM.

PLoS One. 2014 Sep 11;9(9):e107141. doi: 10.1371/journal.pone.0107141. eCollection 2014.

18.

Functional interfaces between TICAM-2/TRAM and TICAM-1/TRIF in TLR4 signaling.

Funami K, Matsumoto M, Oshiumi H, Inagaki F, Seya T.

Biochem Soc Trans. 2017 Aug 15;45(4):929-935. doi: 10.1042/BST20160259. Epub 2017 Jun 19. Review.

PMID:
28630139
19.

The human adaptor SARM negatively regulates adaptor protein TRIF-dependent Toll-like receptor signaling.

Carty M, Goodbody R, Schröder M, Stack J, Moynagh PN, Bowie AG.

Nat Immunol. 2006 Oct;7(10):1074-81. Epub 2006 Sep 10.

PMID:
16964262
20.

Rip1 mediates the Trif-dependent toll-like receptor 3- and 4-induced NF-{kappa}B activation but does not contribute to interferon regulatory factor 3 activation.

Cusson-Hermance N, Khurana S, Lee TH, Fitzgerald KA, Kelliher MA.

J Biol Chem. 2005 Nov 4;280(44):36560-6. Epub 2005 Aug 22.

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