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The loop connecting metal-binding domains 3 and 4 of ATP7B is a target of a kinase-mediated phosphorylation.

Bartee MY, Ralle M, Lutsenko S.

Biochemistry. 2009 Jun 23;48(24):5573-81. doi: 10.1021/bi900325k.


Communication between the N and C termini is required for copper-stimulated Ser/Thr phosphorylation of Cu(I)-ATPase (ATP7B).

Braiterman LT, Gupta A, Chaerkady R, Cole RN, Hubbard AL.

J Biol Chem. 2015 Apr 3;290(14):8803-19. doi: 10.1074/jbc.M114.627414. Epub 2015 Feb 9.


Involvement of protein kinase D in expression and trafficking of ATP7B (copper ATPase).

Pilankatta R, Lewis D, Inesi G.

J Biol Chem. 2011 Mar 4;286(9):7389-96. doi: 10.1074/jbc.M110.171454. Epub 2010 Dec 27.


Interactions between copper-binding sites determine the redox status and conformation of the regulatory N-terminal domain of ATP7B.

LeShane ES, Shinde U, Walker JM, Barry AN, Blackburn NJ, Ralle M, Lutsenko S.

J Biol Chem. 2010 Feb 26;285(9):6327-36. doi: 10.1074/jbc.M109.074633. Epub 2009 Dec 23.


The role of metal binding and phosphorylation domains in the regulation of cisplatin-induced trafficking of ATP7B.

Safaei R, Adams PL, Mathews RA, Manorek G, Howell SB.

Metallomics. 2013 Aug;5(8):964-72. doi: 10.1039/c3mt00131h.


Molecular events initiating exit of a copper-transporting ATPase ATP7B from the trans-Golgi network.

Hasan NM, Gupta A, Polishchuk E, Yu CH, Polishchuk R, Dmitriev OY, Lutsenko S.

J Biol Chem. 2012 Oct 19;287(43):36041-50. doi: 10.1074/jbc.M112.370403. Epub 2012 Aug 16.


Sequence variation in the ATP-binding domain of the Wilson disease transporter, ATP7B, affects copper transport in a yeast model system.

Hsi G, Cullen LM, Macintyre G, Chen MM, Glerum DM, Cox DW.

Hum Mutat. 2008 Apr;29(4):491-501. doi: 10.1002/humu.20674.


Intracellular trafficking of the human Wilson protein: the role of the six N-terminal metal-binding sites.

Cater MA, Forbes J, La Fontaine S, Cox D, Mercer JF.

Biochem J. 2004 Jun 15;380(Pt 3):805-13.


Interactions between metal-binding domains modulate intracellular targeting of Cu(I)-ATPase ATP7B, as revealed by nanobody binding.

Huang Y, Nokhrin S, Hassanzadeh-Ghassabeh G, Yu CH, Yang H, Barry AN, Tonelli M, Markley JL, Muyldermans S, Dmitriev OY, Lutsenko S.

J Biol Chem. 2014 Nov 21;289(47):32682-93. doi: 10.1074/jbc.M114.580845. Epub 2014 Sep 24.


Copper-dependent interaction of dynactin subunit p62 with the N terminus of ATP7B but not ATP7A.

Lim CM, Cater MA, Mercer JF, La Fontaine S.

J Biol Chem. 2006 May 19;281(20):14006-14. Epub 2006 Mar 22.


The role of the invariant His-1069 in folding and function of the Wilson's disease protein, the human copper-transporting ATPase ATP7B.

Tsivkovskii R, Efremov RG, Lutsenko S.

J Biol Chem. 2003 Apr 11;278(15):13302-8. Epub 2003 Jan 27.


Cellular copper levels determine the phenotype of the Arg875 variant of ATP7B/Wilson disease protein.

Gupta A, Bhattacharjee A, Dmitriev OY, Nokhrin S, Braiterman L, Hubbard AL, Lutsenko S.

Proc Natl Acad Sci U S A. 2011 Mar 29;108(13):5390-5. doi: 10.1073/pnas.1014959108. Epub 2011 Mar 15.


Polarized sorting of the copper transporter ATP7B in neurons mediated by recognition of a dileucine signal by AP-1.

Jain S, Farías GG, Bonifacino JS.

Mol Biol Cell. 2015 Jan 15;26(2):218-28. doi: 10.1091/mbc.E14-07-1177. Epub 2014 Nov 5.


Biochemical basis of regulation of human copper-transporting ATPases.

Lutsenko S, LeShane ES, Shinde U.

Arch Biochem Biophys. 2007 Jul 15;463(2):134-48. Epub 2007 May 2. Review.


Hepatic copper-transporting ATPase ATP7B: function and inactivation at the molecular and cellular level.

Bartee MY, Lutsenko S.

Biometals. 2007 Jun;20(3-4):627-37. Epub 2007 Feb 1. Review.


Copper directs ATP7B to the apical domain of hepatic cells via basolateral endosomes.

Nyasae LK, Schell MJ, Hubbard AL.

Traffic. 2014 Dec;15(12):1344-65. doi: 10.1111/tra.12229. Epub 2014 Oct 27. Erratum in: Traffic. 2015 Jan;16(1):99.


Critical roles for the COOH terminus of the Cu-ATPase ATP7B in protein stability, trans-Golgi network retention, copper sensing, and retrograde trafficking.

Braiterman L, Nyasae L, Leves F, Hubbard AL.

Am J Physiol Gastrointest Liver Physiol. 2011 Jul;301(1):G69-81. doi: 10.1152/ajpgi.00038.2011. Epub 2011 Mar 31.


Copper binding triggers compaction in N-terminal tail of human copper pump ATP7B.

Mondol T, Åden J, Wittung-Stafshede P.

Biochem Biophys Res Commun. 2016 Feb 12;470(3):663-669. doi: 10.1016/j.bbrc.2016.01.085. Epub 2016 Jan 18.


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