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Obscurin interacts with a novel isoform of MyBP-C slow at the periphery of the sarcomeric M-band and regulates thick filament assembly.

Ackermann MA, Hu LY, Bowman AL, Bloch RJ, Kontrogianni-Konstantopoulos A.

Mol Biol Cell. 2009 Jun;20(12):2963-78. doi: 10.1091/mbc.E08-12-1251. Epub 2009 Apr 29.


Obscurin regulates the organization of myosin into A bands.

Kontrogianni-Konstantopoulos A, Catino DH, Strong JC, Randall WR, Bloch RJ.

Am J Physiol Cell Physiol. 2004 Jul;287(1):C209-17. Epub 2004 Mar 10.


Obscurin: a multitasking muscle giant.

Kontrogianni-Konstantopoulos A, Bloch RJ.

J Muscle Res Cell Motil. 2005;26(6-8):419-26. Review.


Binding of an ankyrin-1 isoform to obscurin suggests a molecular link between the sarcoplasmic reticulum and myofibrils in striated muscles.

Bagnato P, Barone V, Giacomello E, Rossi D, Sorrentino V.

J Cell Biol. 2003 Jan 20;160(2):245-53. Epub 2003 Jan 13.


Interactions with titin and myomesin target obscurin and obscurin-like 1 to the M-band: implications for hereditary myopathies.

Fukuzawa A, Lange S, Holt M, Vihola A, Carmignac V, Ferreiro A, Udd B, Gautel M.

J Cell Sci. 2008 Jun 1;121(11):1841-51. doi: 10.1242/jcs.028019. Epub 2008 May 13.


Early incorporation of obscurin into nascent sarcomeres: implication for myofibril assembly during cardiac myogenesis.

Borisov AB, Martynova MG, Russell MW.

Histochem Cell Biol. 2008 Apr;129(4):463-78. doi: 10.1007/s00418-008-0378-y. Epub 2008 Jan 25.


Obscurin modulates the assembly and organization of sarcomeres and the sarcoplasmic reticulum.

Kontrogianni-Konstantopoulos A, Catino DH, Strong JC, Sutter S, Borisov AB, Pumplin DW, Russell MW, Bloch RJ.

FASEB J. 2006 Oct;20(12):2102-11.


The rho-guanine nucleotide exchange factor domain of obscurin activates rhoA signaling in skeletal muscle.

Ford-Speelman DL, Roche JA, Bowman AL, Bloch RJ.

Mol Biol Cell. 2009 Sep;20(17):3905-17. doi: 10.1091/mbc.E08-10-1029. Epub 2009 Jul 15.


The rho-guanine nucleotide exchange factor domain of obscurin regulates assembly of titin at the Z-disk through interactions with Ran binding protein 9.

Bowman AL, Catino DH, Strong JC, Randall WR, Kontrogianni-Konstantopoulos A, Bloch RJ.

Mol Biol Cell. 2008 Sep;19(9):3782-92. doi: 10.1091/mbc.E08-03-0237. Epub 2008 Jun 25.


Molecular interactions with obscurin are involved in the localization of muscle-specific small ankyrin1 isoforms to subcompartments of the sarcoplasmic reticulum.

Armani A, Galli S, Giacomello E, Bagnato P, Barone V, Rossi D, Sorrentino V.

Exp Cell Res. 2006 Nov 1;312(18):3546-58. Epub 2006 Aug 16.


The N-terminal end of nebulin interacts with tropomodulin at the pointed ends of the thin filaments.

McElhinny AS, Kolmerer B, Fowler VM, Labeit S, Gregorio CC.

J Biol Chem. 2001 Jan 5;276(1):583-92.


Dynamics of obscurin localization during differentiation and remodeling of cardiac myocytes: obscurin as an integrator of myofibrillar structure.

Borisov AB, Kontrogianni-Konstantopoulos A, Bloch RJ, Westfall MV, Russell MW.

J Histochem Cytochem. 2004 Sep;52(9):1117-27.


The complete gene sequence of titin, expression of an unusual approximately 700-kDa titin isoform, and its interaction with obscurin identify a novel Z-line to I-band linking system.

Bang ML, Centner T, Fornoff F, Geach AJ, Gotthardt M, McNabb M, Witt CC, Labeit D, Gregorio CC, Granzier H, Labeit S.

Circ Res. 2001 Nov 23;89(11):1065-72.


Obscurin is a ligand for small ankyrin 1 in skeletal muscle.

Kontrogianni-Konstantopoulos A, Jones EM, Van Rossum DB, Bloch RJ.

Mol Biol Cell. 2003 Mar;14(3):1138-48.


Localization of ank1.5 in the sarcoplasmic reticulum precedes that of SERCA and RyR: relationship with the organization of obscurin in developing sarcomeres.

Giacomello E, Sorrentino V.

Histochem Cell Biol. 2009 Mar;131(3):371-82. doi: 10.1007/s00418-008-0534-4. Epub 2008 Nov 11.


Axial distribution of myosin binding protein-C is unaffected by mutations in human cardiac and skeletal muscle.

Vydyanath A, Gurnett CA, Marston S, Luther PK.

J Muscle Res Cell Motil. 2012 May;33(1):61-74. doi: 10.1007/s10974-012-9286-9. Epub 2012 Mar 14.


De novo myofibrillogenesis in C2C12 cells: evidence for the independent assembly of M bands and Z disks.

Kontrogianni-Konstantopoulos A, Catino DH, Strong JC, Bloch RJ.

Am J Physiol Cell Physiol. 2006 Feb;290(2):C626-37. Epub 2005 Oct 5.


Myosin binding protein-C slow: an intricate subfamily of proteins.

Ackermann MA, Kontrogianni-Konstantopoulos A.

J Biomed Biotechnol. 2010;2010:652065. doi: 10.1155/2010/652065. Epub 2010 Apr 8. Review.


Specific interaction of the potassium channel beta-subunit minK with the sarcomeric protein T-cap suggests a T-tubule-myofibril linking system.

Furukawa T, Ono Y, Tsuchiya H, Katayama Y, Bang ML, Labeit D, Labeit S, Inagaki N, Gregorio CC.

J Mol Biol. 2001 Nov 2;313(4):775-84.


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