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Items: 1 to 20 of 263

1.

Synthesis of analogs of forodesine HCl, a human purine nucleoside phosphorylase inhibitor-Part I.

Kamath VP, Xue J, Juarez-Brambila JJ, Morris CB, Ganorkar R, Morris PE Jr.

Bioorg Med Chem Lett. 2009 May 15;19(10):2624-6. doi: 10.1016/j.bmcl.2009.04.017. Epub 2009 Apr 9.

PMID:
19386498
2.

Synthesis of analogs of forodesine HCl, a human purine nucleoside phosphorylase inhibitor-Part II.

Kamath VP, Xue J, Juarez-Brambila JJ.

Bioorg Med Chem Lett. 2009 May 15;19(10):2627-9. doi: 10.1016/j.bmcl.2009.04.018. Epub 2009 Apr 9.

PMID:
19386496
3.

Forodesine (BCX-1777, Immucillin H)--a new purine nucleoside analogue: mechanism of action and potential clinical application.

Korycka A, Błoński JZ, Robak T.

Mini Rev Med Chem. 2007 Sep;7(9):976-83. Review.

PMID:
17897085
4.
5.

Exploring structure-activity relationships of transition state analogues of human purine nucleoside phosphorylase.

Evans GB, Furneaux RH, Lewandowicz A, Schramm VL, Tyler PC.

J Med Chem. 2003 Jul 17;46(15):3412-23.

PMID:
12852771
6.

Synthesis of a transition state analogue inhibitor of purine nucleoside phosphorylase via the Mannich reaction.

Evans GB, Furneaux RH, Tyler PC, Schramm VL.

Org Lett. 2003 Oct 2;5(20):3639-40.

PMID:
14507192
7.

One-third-the-sites transition-state inhibitors for purine nucleoside phosphorylase.

Miles RW, Tyler PC, Furneaux RH, Bagdassarian CK, Schramm VL.

Biochemistry. 1998 Jun 16;37(24):8615-21.

PMID:
9628722
8.
9.

[Tight binding transition state analogues of purine nucleoside phosphorylase--meaning, design and properties].

Lewandowicz A.

Postepy Biochem. 2004;50(3):218-27. Review. Polish. No abstract available.

PMID:
15822751
10.

Syntheses and bio-activities of the L-enantiomers of two potent transition state analogue inhibitors of purine nucleoside phosphorylases.

Clinch K, Evans GB, Fleet GW, Furneaux RH, Johnson SW, Lenz DH, Mee SP, Rands PR, Schramm VL, Taylor Ringia EA, Tyler PC.

Org Biomol Chem. 2006 Mar 21;4(6):1131-9. Epub 2006 Jan 26.

PMID:
16525558
11.

Forodesine, an inhibitor of purine nucleoside phosphorylase, induces apoptosis in chronic lymphocytic leukemia cells.

Balakrishnan K, Nimmanapalli R, Ravandi F, Keating MJ, Gandhi V.

Blood. 2006 Oct 1;108(7):2392-8. Epub 2006 Jun 15.

12.

A proof-of-principle pharmacokinetic, pharmacodynamic, and clinical study with purine nucleoside phosphorylase inhibitor immucillin-H (BCX-1777, forodesine).

Gandhi V, Kilpatrick JM, Plunkett W, Ayres M, Harman L, Du M, Bantia S, Davisson J, Wierda WG, Faderl S, Kantarjian H, Thomas D.

Blood. 2005 Dec 15;106(13):4253-60. Epub 2005 Aug 30.

13.

An efficient and large-scale enantioselective synthesis of PNP405: a purine nucleoside phosphorylase inhibitor.

Prashad M, Har D, Chen L, Kim HY, Repic O, Blacklock TJ.

J Org Chem. 2002 Sep 20;67(19):6612-7.

PMID:
12227788
14.

Purine nucleoside phosphorylase inhibitor BCX-1777 (Immucillin-H)--a novel potent and orally active immunosuppressive agent.

Bantia S, Miller PJ, Parker CD, Ananth SL, Horn LL, Kilpatrick JM, Morris PE, Hutchison TL, Montgomery JA, Sandhu JS.

Int Immunopharmacol. 2001 Jun;1(6):1199-210.

PMID:
11407314
15.

8-Aza-immucillins as transition-state analogue inhibitors of purine nucleoside phosphorylase and nucleoside hydrolases.

Evans GB, Furneaux RH, Gainsford GJ, Hanson JC, Kicska GA, Sauve AA, Schramm VL, Tyler PC.

J Med Chem. 2003 Jan 2;46(1):155-60.

PMID:
12502369
16.
17.

Synthesis and pharmacokinetic and pharmacodynamic evaluation of the forodesine HCl analog BCX-3040.

Kezar HS 3rd, Kilpatrick JM, Phillips D, Kellogg D, Zhang J, Morris PE Jr.

Nucleosides Nucleotides Nucleic Acids. 2005;24(10-12):1817-30.

PMID:
16438050
18.

New catalytic mechanism for human purine nucleoside phosphorylase.

Canduri F, Fadel V, Basso LA, Palma MS, Santos DS, de Azevedo WF Jr.

Biochem Biophys Res Commun. 2005 Feb 18;327(3):646-9.

PMID:
15649395
19.

Novel purine nucleoside analogues for T-cell-lineage acute lymphoblastic leukaemia and lymphoma.

Ravandi F, Gandhi V.

Expert Opin Investig Drugs. 2006 Dec;15(12):1601-13. Review.

PMID:
17107284
20.

Influence of bone marrow stromal microenvironment on forodesine-induced responses in CLL primary cells.

Balakrishnan K, Burger JA, Quiroga MP, Henneberg M, Ayres ML, Wierda WG, Gandhi V.

Blood. 2010 Aug 19;116(7):1083-91. doi: 10.1182/blood-2009-10-246199. Epub 2010 May 4.

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