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The yeast PNC1 longevity gene is up-regulated by mRNA mistranslation.

Silva RM, Duarte IC, Paredes JA, Lima-Costa T, Perrot M, Boucherie H, Goodfellow BJ, Gomes AC, Mateus DD, Moura GR, Santos MA.

PLoS One. 2009;4(4):e5212. doi: 10.1371/journal.pone.0005212. Epub 2009 Apr 17.


Multiple pathways regulating the calorie restriction response in yeast.

Rahat O, Maoz N, Cohen HY.

J Gerontol A Biol Sci Med Sci. 2011 Feb;66(2):163-9. doi: 10.1093/gerona/glq165. Epub 2010 Nov 15.


Nicotinamide and PNC1 govern lifespan extension by calorie restriction in Saccharomyces cerevisiae.

Anderson RM, Bitterman KJ, Wood JG, Medvedik O, Sinclair DA.

Nature. 2003 May 8;423(6936):181-5.


Life span extension and neuronal cell protection by Drosophila nicotinamidase.

Balan V, Miller GS, Kaplun L, Balan K, Chong ZZ, Li F, Kaplun A, VanBerkum MF, Arking R, Freeman DC, Maiese K, Tzivion G.

J Biol Chem. 2008 Oct 10;283(41):27810-9. doi: 10.1074/jbc.M804681200. Epub 2008 Aug 4.


Stress exposure results in increased peroxisomal levels of yeast Pnc1 and Gpd1, which are imported via a piggy-backing mechanism.

Kumar S, Singh R, Williams CP, van der Klei IJ.

Biochim Biophys Acta. 2016 Jan;1863(1):148-56. doi: 10.1016/j.bbamcr.2015.10.017. Epub 2015 Oct 26.


Evolution of Robustness to Protein Mistranslation by Accelerated Protein Turnover.

Kalapis D, Bezerra AR, Farkas Z, Horvath P, Bódi Z, Daraba A, Szamecz B, Gut I, Bayes M, Santos MA, Pál C.

PLoS Biol. 2015 Nov 6;13(11):e1002291. doi: 10.1371/journal.pbio.1002291. eCollection 2015.


Genetic selection for mistranslation rescues a defective co-chaperone in yeast.

Hoffman KS, Berg MD, Shilton BH, Brandl CJ, O'Donoghue P.

Nucleic Acids Res. 2017 Apr 7;45(6):3407-3421. doi: 10.1093/nar/gkw1021.


Structural and kinetic isotope effect studies of nicotinamidase (Pnc1) from Saccharomyces cerevisiae.

Smith BC, Anderson MA, Hoadley KA, Keck JL, Cleland WW, Denu JM.

Biochemistry. 2012 Jan 10;51(1):243-56. doi: 10.1021/bi2015508. Epub 2011 Dec 29.


Chromate-induced sulfur starvation and mRNA mistranslation in yeast are linked in a common mechanism of Cr toxicity.

Holland SL, Ghosh E, Avery SV.

Toxicol In Vitro. 2010 Sep;24(6):1764-7. doi: 10.1016/j.tiv.2010.07.006. Epub 2010 Jul 14.


Nicotinamide clearance by Pnc1 directly regulates Sir2-mediated silencing and longevity.

Gallo CM, Smith DL Jr, Smith JS.

Mol Cell Biol. 2004 Feb;24(3):1301-12.


Global mRNA expression analysis in myosin II deficient strains of Saccharomyces cerevisiae reveals an impairment of cell integrity functions.

Rodríguez-Quiñones JF, Irizarry RA, Díaz-Blanco NL, Rivera-Molina FE, Gómez-Garzón D, Rodríguez-Medina JR.

BMC Genomics. 2008 Jan 23;9:34. doi: 10.1186/1471-2164-9-34.


Stress profiling of longevity mutants identifies Afg3 as a mitochondrial determinant of cytoplasmic mRNA translation and aging.

Delaney JR, Ahmed U, Chou A, Sim S, Carr D, Murakami CJ, Schleit J, Sutphin GL, An EH, Castanza A, Fletcher M, Higgins S, Jelic M, Klum S, Muller B, Peng ZJ, Rai D, Ros V, Singh M, Wende HV, Kennedy BK, Kaeberlein M.

Aging Cell. 2013 Feb;12(1):156-66. doi: 10.1111/acel.12032. Epub 2012 Dec 25.


Longevity research. Single signal unites treatments that prolong life.

Strauss E.

Science. 2003 May 9;300(5621):881-3. No abstract available.


Post-transcriptional regulation in the myo1Δ mutant of Saccharomyces cerevisiae.

Rivera-Ruiz ME, Rodríguez-Quiñones JF, Akamine P, Rodríguez-Medina JR.

BMC Genomics. 2010 Dec 2;11:690. doi: 10.1186/1471-2164-11-690.

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