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Items: 1 to 20 of 475


Genetic deficit of SK3 and IK1 channels disrupts the endothelium-derived hyperpolarizing factor vasodilator pathway and causes hypertension.

Brähler S, Kaistha A, Schmidt VJ, Wölfle SE, Busch C, Kaistha BP, Kacik M, Hasenau AL, Grgic I, Si H, Bond CT, Adelman JP, Wulff H, de Wit C, Hoyer J, Köhler R.

Circulation. 2009 May 5;119(17):2323-32. doi: 10.1161/CIRCULATIONAHA.108.846634. Epub 2009 Apr 20.


Impaired endothelium-derived hyperpolarizing factor-mediated dilations and increased blood pressure in mice deficient of the intermediate-conductance Ca2+-activated K+ channel.

Si H, Heyken WT, Wölfle SE, Tysiac M, Schubert R, Grgic I, Vilianovich L, Giebing G, Maier T, Gross V, Bader M, de Wit C, Hoyer J, Köhler R.

Circ Res. 2006 Sep 1;99(5):537-44. Epub 2006 Jul 27.


Crucial importance of the endothelial K+ channel SK3 and connexin40 in arteriolar dilations during skeletal muscle contraction.

Milkau M, Köhler R, de Wit C.

FASEB J. 2010 Sep;24(9):3572-9. doi: 10.1096/fj.10-158956. Epub 2010 Apr 28.


Altered expression of small-conductance Ca2+-activated K+ (SK3) channels modulates arterial tone and blood pressure.

Taylor MS, Bonev AD, Gross TP, Eckman DM, Brayden JE, Bond CT, Adelman JP, Nelson MT.

Circ Res. 2003 Jul 25;93(2):124-31. Epub 2003 Jun 12.


Amplification of EDHF-type vasodilatations in TRPC1-deficient mice.

Schmidt K, Dubrovska G, Nielsen G, Fesüs G, Uhrenholt TR, Hansen PB, Gudermann T, Dietrich A, Gollasch M, de Wit C, Köhler R.

Br J Pharmacol. 2010 Dec;161(8):1722-33. doi: 10.1111/j.1476-5381.2010.00985.x.


Selective blockade of endothelial Ca2+-activated small- and intermediate-conductance K+-channels suppresses EDHF-mediated vasodilation.

Eichler I, Wibawa J, Grgic I, Knorr A, Brakemeier S, Pries AR, Hoyer J, Köhler R.

Br J Pharmacol. 2003 Feb;138(4):594-601.


Endothelial Ca+-activated K+ channels in normal and impaired EDHF-dilator responses--relevance to cardiovascular pathologies and drug discovery.

Grgic I, Kaistha BP, Hoyer J, Köhler R.

Br J Pharmacol. 2009 Jun;157(4):509-26. doi: 10.1111/j.1476-5381.2009.00132.x. Epub 2009 Mar 19. Review.


Endothelial potassium channels, endothelium-dependent hyperpolarization and the regulation of vascular tone in health and disease.

Coleman HA, Tare M, Parkington HC.

Clin Exp Pharmacol Physiol. 2004 Sep;31(9):641-9. Review.


Endothelial dysfunction and blood pressure alterations in K+-channel transgenic mice.

Köhler R, Ruth P.

Pflugers Arch. 2010 May;459(6):969-76. doi: 10.1007/s00424-010-0819-z. Epub 2010 Mar 28. Review.


Prominent role of KCa3.1 in endothelium-derived hyperpolarizing factor-type dilations and conducted responses in the microcirculation in vivo.

Wölfle SE, Schmidt VJ, Hoyer J, Köhler R, de Wit C.

Cardiovasc Res. 2009 Jun 1;82(3):476-83. doi: 10.1093/cvr/cvp060. Epub 2009 Feb 13.


Reduced expression of SKCa and IKCa channel proteins in rat small mesenteric arteries during angiotensin II-induced hypertension.

Hilgers RH, Webb RC.

Am J Physiol Heart Circ Physiol. 2007 May;292(5):H2275-84. Epub 2007 Jan 5.


Endothelium-dependent vasodilation in myogenically active mouse skeletal muscle arterioles: role of EDH and K(+) channels.

Potocnik SJ, McSherry I, Ding H, Murphy TV, Kotecha N, Dora KA, Yuill KH, Triggle CR, Hill MA.

Microcirculation. 2009 Jul;16(5):377-90; 1 p following 390. doi: 10.1080/10739680902804042. Epub 2009 May 7.


Positive feedback regulation of agonist-stimulated endothelial Ca2+ dynamics by KCa3.1 channels in mouse mesenteric arteries.

Qian X, Francis M, Köhler R, Solodushko V, Lin M, Taylor MS.

Arterioscler Thromb Vasc Biol. 2014 Jan;34(1):127-35. doi: 10.1161/ATVBAHA.113.302506. Epub 2013 Oct 31.


Obesity up-regulates intermediate conductance calcium-activated potassium channels and myoendothelial gap junctions to maintain endothelial vasodilator function.

Chadha PS, Haddock RE, Howitt L, Morris MJ, Murphy TV, Grayson TH, Sandow SL.

J Pharmacol Exp Ther. 2010 Nov;335(2):284-93. doi: 10.1124/jpet.110.167593. Epub 2010 Jul 29.


Endothelium-derived hyperpolarizing factor-mediated renal vasodilatory response is impaired during acute and chronic hyperhomocysteinemia.

De Vriese AS, Blom HJ, Heil SG, Mortier S, Kluijtmans LA, Van de Voorde J, Lameire NH.

Circulation. 2004 May 18;109(19):2331-6. Epub 2004 Apr 26.


Twenty-four-hour exposure to altered blood flow modifies endothelial Ca2+-activated K+ channels in rat mesenteric arteries.

Hilgers RH, Janssen GM, Fazzi GE, De Mey JG.

J Pharmacol Exp Ther. 2010 Apr;333(1):210-7. doi: 10.1124/jpet.109.161448. Epub 2009 Dec 29.


Increases in endothelial Ca(2+) activate K(Ca) channels and elicit EDHF-type arteriolar dilation via gap junctions.

Ungvari Z, Csiszar A, Koller A.

Am J Physiol Heart Circ Physiol. 2002 May;282(5):H1760-7.


Endothelial SK3 channel-associated Ca2+ microdomains modulate blood pressure.

Yap FC, Weber DS, Taylor MS, Townsley MI, Comer BS, Maylie J, Adelman JP, Lin MT.

Am J Physiol Heart Circ Physiol. 2016 May 1;310(9):H1151-63. doi: 10.1152/ajpheart.00787.2015. Epub 2016 Mar 4.


Calcium-activated potassium channel and connexin expression in small mesenteric arteries from eNOS-deficient (eNOS-/-) and eNOS-expressing (eNOS+/+) mice.

Ceroni L, Ellis A, Wiehler WB, Jiang YF, Ding H, Triggle CR.

Eur J Pharmacol. 2007 Apr 10;560(2-3):193-200. Epub 2007 Jan 19.


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