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Items: 1 to 20 of 157

1.

Modulation of the transient receptor potential vanilloid channel TRPV4 by 4alpha-phorbol esters: a structure-activity study.

Klausen TK, Pagani A, Minassi A, Ech-Chahad A, Prenen J, Owsianik G, Hoffmann EK, Pedersen SF, Appendino G, Nilius B.

J Med Chem. 2009 May 14;52(9):2933-9. doi: 10.1021/jm9001007.

PMID:
19361196
2.

Determinants of 4 alpha-phorbol sensitivity in transmembrane domains 3 and 4 of the cation channel TRPV4.

Vriens J, Owsianik G, Janssens A, Voets T, Nilius B.

J Biol Chem. 2007 Apr 27;282(17):12796-803. Epub 2007 Mar 6.

3.
4.

Antidipsogenic effects of a TRPV4 agonist, 4alpha-phorbol 12,13-didecanoate, injected into the cerebroventricle.

Tsushima H, Mori M.

Am J Physiol Regul Integr Comp Physiol. 2006 Jun;290(6):R1736-41. Epub 2006 Jan 26.

5.

Stimulus-specific modulation of the cation channel TRPV4 by PACSIN 3.

D'hoedt D, Owsianik G, Prenen J, Cuajungco MP, Grimm C, Heller S, Voets T, Nilius B.

J Biol Chem. 2008 Mar 7;283(10):6272-80. doi: 10.1074/jbc.M706386200. Epub 2008 Jan 3.

6.

Cardiac fibroblasts have functional TRPV4 activated by 4alpha-phorbol 12,13-didecanoate.

Hatano N, Itoh Y, Muraki K.

Life Sci. 2009 Dec 16;85(23-26):808-14. doi: 10.1016/j.lfs.2009.10.013. Epub 2009 Oct 30.

PMID:
19879881
7.

Transient receptor potential vanilloid-4 has a major role in visceral hypersensitivity symptoms.

Cenac N, Altier C, Chapman K, Liedtke W, Zamponi G, Vergnolle N.

Gastroenterology. 2008 Sep;135(3):937-46, 946.e1-2. doi: 10.1053/j.gastro.2008.05.024. Epub 2008 May 10.

PMID:
18565335
8.

The TRPV4 channel is a novel regulator of intracellular Ca2+ in human esophageal epithelial cells.

Ueda T, Shikano M, Kamiya T, Joh T, Ugawa S.

Am J Physiol Gastrointest Liver Physiol. 2011 Jul;301(1):G138-47. doi: 10.1152/ajpgi.00511.2010. Epub 2011 Apr 14.

10.

Activation of TRPV4 channels (hVRL-2/mTRP12) by phorbol derivatives.

Watanabe H, Davis JB, Smart D, Jerman JC, Smith GD, Hayes P, Vriens J, Cairns W, Wissenbach U, Prenen J, Flockerzi V, Droogmans G, Benham CD, Nilius B.

J Biol Chem. 2002 Apr 19;277(16):13569-77. Epub 2002 Feb 4.

11.

Modulation of the Ca2 permeable cation channel TRPV4 by cytochrome P450 epoxygenases in vascular endothelium.

Vriens J, Owsianik G, Fisslthaler B, Suzuki M, Janssens A, Voets T, Morisseau C, Hammock BD, Fleming I, Busse R, Nilius B.

Circ Res. 2005 Oct 28;97(9):908-15. Epub 2005 Sep 22.

12.

Functional TRPV4 channels are expressed in mouse skeletal muscle and can modulate resting Ca2+ influx and muscle fatigue.

Pritschow BW, Lange T, Kasch J, Kunert-Keil C, Liedtke W, Brinkmeier H.

Pflugers Arch. 2011 Jan;461(1):115-22. doi: 10.1007/s00424-010-0883-4. Epub 2010 Oct 6.

PMID:
20924600
13.

Functional coupling of TRPV4 cationic channel and large conductance, calcium-dependent potassium channel in human bronchial epithelial cell lines.

Fernández-Fernández JM, Andrade YN, Arniges M, Fernandes J, Plata C, Rubio-Moscardo F, Vázquez E, Valverde MA.

Pflugers Arch. 2008 Oct;457(1):149-59. doi: 10.1007/s00424-008-0516-3. Epub 2008 May 6.

PMID:
18458941
14.

Characterization of transient receptor potential vanilloid channel 4 (TRPV4) in human corneal endothelial cells.

Mergler S, Valtink M, Taetz K, Sahlmüller M, Fels G, Reinach PS, Engelmann K, Pleyer U.

Exp Eye Res. 2011 Nov;93(5):710-9. doi: 10.1016/j.exer.2011.09.021. Epub 2011 Oct 6.

PMID:
21996372
15.

Tyrosine phosphorylation modulates the activity of TRPV4 in response to defined stimuli.

Wegierski T, Lewandrowski U, Müller B, Sickmann A, Walz G.

J Biol Chem. 2009 Jan 30;284(5):2923-33. doi: 10.1074/jbc.M805357200. Epub 2008 Nov 25.

16.

Expression and functional characterization of transient receptor potential vanilloid-related channel 4 (TRPV4) in rat cortical astrocytes.

Benfenati V, Amiry-Moghaddam M, Caprini M, Mylonakou MN, Rapisarda C, Ottersen OP, Ferroni S.

Neuroscience. 2007 Sep 21;148(4):876-92. Epub 2007 Jul 17.

PMID:
17719182
17.

Stimulation of transient receptor potential vanilloid 4 channel suppresses abnormal activation of microglia induced by lipopolysaccharide.

Konno M, Shirakawa H, Iida S, Sakimoto S, Matsutani I, Miyake T, Kageyama K, Nakagawa T, Shibasaki K, Kaneko S.

Glia. 2012 May;60(5):761-70. doi: 10.1002/glia.22306. Epub 2012 Feb 13.

PMID:
22331560
18.

Swelling-activated Ca2+ entry via TRPV4 channel is defective in cystic fibrosis airway epithelia.

Arniges M, Vázquez E, Fernández-Fernández JM, Valverde MA.

J Biol Chem. 2004 Dec 24;279(52):54062-8. Epub 2004 Oct 15.

19.

Involvement of TRPV1 and TRPV4 channels in migration of rat pulmonary arterial smooth muscle cells.

Martin E, Dahan D, Cardouat G, Gillibert-Duplantier J, Marthan R, Savineau JP, Ducret T.

Pflugers Arch. 2012 Sep;464(3):261-72. doi: 10.1007/s00424-012-1136-5. Epub 2012 Jul 22.

PMID:
22820913
20.

N-((1S)-1-{[4-((2S)-2-{[(2,4-dichlorophenyl)sulfonyl]amino}-3-hydroxypropanoyl)-1-piperazinyl]carbonyl}-3-methylbutyl)-1-benzothiophene-2-carboxamide (GSK1016790A), a novel and potent transient receptor potential vanilloid 4 channel agonist induces urinary bladder contraction and hyperactivity: Part I.

Thorneloe KS, Sulpizio AC, Lin Z, Figueroa DJ, Clouse AK, McCafferty GP, Chendrimada TP, Lashinger ES, Gordon E, Evans L, Misajet BA, Demarini DJ, Nation JH, Casillas LN, Marquis RW, Votta BJ, Sheardown SA, Xu X, Brooks DP, Laping NJ, Westfall TD.

J Pharmacol Exp Ther. 2008 Aug;326(2):432-42. doi: 10.1124/jpet.108.139295. Epub 2008 May 22. Erratum in: J Pharmacol Exp Ther. 2011 Jul;338(1):410.

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