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Connective tissue growth factor confers drug resistance in breast cancer through concomitant up-regulation of Bcl-xL and cIAP1.

Wang MY, Chen PS, Prakash E, Hsu HC, Huang HY, Lin MT, Chang KJ, Kuo ML.

Cancer Res. 2009 Apr 15;69(8):3482-91. doi: 10.1158/0008-5472.CAN-08-2524. Epub 2009 Apr 7.


Cyr61 expression confers resistance to apoptosis in breast cancer MCF-7 cells by a mechanism of NF-kappaB-dependent XIAP up-regulation.

Lin MT, Chang CC, Chen ST, Chang HL, Su JL, Chau YP, Kuo ML.

J Biol Chem. 2004 Jun 4;279(23):24015-23. Epub 2004 Mar 24.


Pathogenic role of connective tissue growth factor (CTGF/CCN2) in osteolytic metastasis of breast cancer.

Shimo T, Kubota S, Yoshioka N, Ibaragi S, Isowa S, Eguchi T, Sasaki A, Takigawa M.

J Bone Miner Res. 2006 Jul;21(7):1045-59.


Bcl-xL promotes metastasis of breast cancer cells by induction of cytokines resistance.

Fernández Y, España L, Mañas S, Fabra A, Sierra A.

Cell Death Differ. 2000 Apr;7(4):350-9.


CTGF enhances the motility of breast cancer cells via an integrin-alphavbeta3-ERK1/2-dependent S100A4-upregulated pathway.

Chen PS, Wang MY, Wu SN, Su JL, Hong CC, Chuang SE, Chen MW, Hua KT, Wu YL, Cha ST, Babu MS, Chen CN, Lee PH, Chang KJ, Kuo ML.

J Cell Sci. 2007 Jun 15;120(Pt 12):2053-65.


Activation of extracellular signal-regulated kinases ERK1 and ERK2 induces Bcl-xL up-regulation via inhibition of caspase activities in erythropoietin signaling.

Mori M, Uchida M, Watanabe T, Kirito K, Hatake K, Ozawa K, Komatsu N.

J Cell Physiol. 2003 May;195(2):290-7.


3,3'-diindolylmethane and paclitaxel act synergistically to promote apoptosis in HER2/Neu human breast cancer cells.

McGuire KP, Ngoubilly N, Neavyn M, Lanza-Jacoby S.

J Surg Res. 2006 May 15;132(2):208-13. Epub 2006 Mar 31.


Small inhibitor of Bcl-2, HA14-1, selectively enhanced the apoptotic effect of cisplatin by modulating Bcl-2 family members in MDA-MB-231 breast cancer cells.

Arisan ED, Kutuk O, Tezil T, Bodur C, Telci D, Basaga H.

Breast Cancer Res Treat. 2010 Jan;119(2):271-81. doi: 10.1007/s10549-009-0343-z. Epub 2009 Feb 24.


Scatter factor protects epithelial and carcinoma cells against apoptosis induced by DNA-damaging agents.

Fan S, Wang JA, Yuan RQ, Rockwell S, Andres J, Zlatapolskiy A, Goldberg ID, Rosen EM.

Oncogene. 1998 Jul 16;17(2):131-41.


Extrinsic pathway- and cathepsin-dependent induction of mitochondrial dysfunction are essential for synergistic flavopiridol and vorinostat lethality in breast cancer cells.

Mitchell C, Park MA, Zhang G, Yacoub A, Curiel DT, Fisher PB, Roberts JD, Grant S, Dent P.

Mol Cancer Ther. 2007 Dec;6(12 Pt 1):3101-12. Epub 2007 Dec 7.


Static pressure regulates connective tissue growth factor expression in human mesangial cells.

Hishikawa K, Oemar BS, Nakaki T.

J Biol Chem. 2001 May 18;276(20):16797-803. Epub 2001 Feb 13.


Overactivation of the MEK/ERK pathway in liver tumor cells confers resistance to TGF-{beta}-induced cell death through impairing up-regulation of the NADPH oxidase NOX4.

Caja L, Sancho P, Bertran E, Iglesias-Serret D, Gil J, Fabregat I.

Cancer Res. 2009 Oct 1;69(19):7595-602. doi: 10.1158/0008-5472.CAN-09-1482. Epub 2009 Sep 22.


Connective tissue growth factor induces apoptosis in human breast cancer cell line MCF-7.

Hishikawa K, Oemar BS, Tanner FC, Nakaki T, Lüscher TF, Fujii T.

J Biol Chem. 1999 Dec 24;274(52):37461-6.


Protein kinase C-theta-mediated signals enhance CD4+ T cell survival by up-regulating Bcl-xL.

Manicassamy S, Gupta S, Huang Z, Sun Z.

J Immunol. 2006 Jun 1;176(11):6709-16.

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