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19339712,20373342,16543533,17962045,25162367,36448771,32929366,8669492,23255822,29331531,19268916,20385913,29356823,24603945,19398705,33044487,26839485,19013250,16468304,30422173,27842173,9678319,23624169,37016464,15184600,24495404,20373343,24948815,24702820,17485647,33372875,22348880,33129364,25524955,19587325,29111487,26541776,26208959,11343827,23018443,26302353,10912914,31831374,26298664,15545327,22188720,28319241,20598287,11444802,28143566,16043796,32333488,21700585,9520006,36858305,25893384,23159043,30134963,17337010,15965197,37038190,29592889,31127775,26004017,19388128,20186853,29190651,24972680,15702779,23389995,34477136,21280088,19398704,25988463,16096813,17030756,30991302,31199015,20231448,27029632,18695050,28574812,24189376,30107289,22213821,15522251,10364643,23541187,22189452,15184629,21422459,24748674,19162107,20065247,15591802,32603776,15642911,20930274,23627755,33521872,30991617,19346482,22864813,21357834,19139300,31367008,20065135,19164761,29982493,9669695,23022416,24145819,34551374,20535486,33443136,18036514,20479234,18632806,29672664,36383681,31970802,19940172,30958345,34228042,27867033,22311091,30136422,36096822,29869063,32282020,16328515,35236958,26221954,36522743,23652625,33733657,17499392,20176414,18163432,24797962,27683850,34508954,24276092,31350163,35964194,31846965,24596678,36226340,22961445,19124691,36201963,29216448,33167837,16971697,37018391,33523050,17928318,24217171,32759192,22232206,32750666,28818092,33569570,28842444,30684189,23157337,23771217,10668711,32304722,19164220,32173556,36086465,22933741,27173368,22405043,15623696,30605058,17541051,31246935,19349226,24985533,36707869,33648793,16802294,25146994,30530186,23572425,32928967,32027932,22162065,11988340,23554933,8644745,29548847,32163130,11041282,19199875,21159973,35317127,28794245,19484916,19668025,31199530,27259692,22544617,24508314,37021572,14966149,36348357,30023168,35410910,20198498,35788729,31159873,26161964,22689192,29752306,29795290,33086924,19720974,21683475,31917799,33985952,30361487,24427295,34798903,21846988,24179803,21163916,31704790,18253865,32783314,19892322,22712640,32847955,30689578,22173784,21892657,24929969,27781145,31831047,18185940,27228100,21324265,32791423,23419831,23553344,29614642,21901424,36284363,19524115,35139885,35122970,23238736,33017488,35753703,25943889,24475827,33548794,33722993,25988462,35142437,32076055,36621019,18058831,33287896,30517207,22393530,36336241,18458218,21098974,33161290,30867273,33023447,24199960,22615835,32948752,35477163,20847408,24613195,22828738,23887281,18201725,21320990,20298684,20217101,20065246,23028511,22637583,31328305,14997020,12593615,35831715,23036023,35121484,10822352,32681391,22695623,33504764,17146288,26251417,20219963,28235680,31571352,30694418,33082443,21710128,23371443,9876967,22972644,33617650,24378418,29883038,22592366,34924383,23407718,17553421,24523481,36436561,23296339,16682673,31191441,31012816,35344819,35471691,18853460,36071110,22805771,31801830,18625856,23957925,24278306,21602657,19605829,28706481,16599940,36457019,11983299,16741934,19901249,30850633,33488947,19204726,29156222,16043284,31964863,34305574,18401023,23828104,17911364,36798327,23275593,27784770,35222254,23840615,22343410,25169676,24838911,18408364,18236001,23216585,30143564,21244352,20819998,24349461,35150834,31733942,21391232,22169231,24381817,30182053,24132374,21346518,34743296,35292558,33952156,30509127,12123847,15048896,32805190,34916904,11992262,23870418,33568538,34200847,24026422,25977462,21803164,18648325,19204163,20570408,34612548,30697632,18581664,23708142,34091034,31133613,33934115,32123170,20153809,34965472,31162121,23883936,19923550,15639310,35473760,32848707,37117777,19251191,35639398,31167933,18666860,23836404,9787187,22272623,15136700,24899141,34108509,15377701,30783964,19812458,31164996,32057528,32034174,31920926,18620351,32209402,28977675,18715507,23912676,29081745,29163142,33014034,24049139,36430248,24781637,20052685,30679421,24585367,32169357,34873813,33813555,32962736,32270596,31745181,23421912,22232000,20625166,34757642,23858411,19766542,32256335,36814324,21550258,19704080,12821754,22672880,19754925,21316814,24179779,25485714,33936415,18317253,29494182,18703605,31923717,28054028,10732803,31717561,17914065,24252240,22056004,35193096,19326964,22015765,35265943,19059308,34985014,20664629,36038268,35099507,18585350,22884479,27103636,30139626,25339884,36321981,22498844,18501477,23183885,32374412,11166947,20139767,24729983,21749214,25383391,32047067,31794505,33060367,33942053,20537201,29951994,32107475,24323049,36805552,21270636,17099589,35940397,32009162,35649659,35623891,31667895,33127824,24276019,23296341,36973045,34587912[uid]

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Effect of APOE genotype on amyloid plaque load and gray matter volume in Alzheimer disease.

Drzezga A, Grimmer T, Henriksen G, Mühlau M, Perneczky R, Miederer I, Praus C, Sorg C, Wohlschläger A, Riemenschneider M, Wester HJ, Foerstl H, Schwaiger M, Kurz A. Drzezga A, et al. Neurology. 2009 Apr 28;72(17):1487-94. doi: 10.1212/WNL.0b013e3181a2e8d0. Epub 2009 Apr 1. Neurology. 2009. PMID: 19339712

Effect of apolipoprotein E on biomarkers of amyloid load and neuronal pathology in Alzheimer disease.

Vemuri P, Wiste HJ, Weigand SD, Knopman DS, Shaw LM, Trojanowski JQ, Aisen PS, Weiner M, Petersen RC, Jack CR Jr; Alzheimer's Disease Neuroimaging Initiative. Vemuri P, et al. Ann Neurol. 2010 Mar;67(3):308-16. doi: 10.1002/ana.21953. Ann Neurol. 2010. PMID: 20373342 Free PMC article.

Genetic associations between cathepsin D exon 2 C-->T polymorphism and Alzheimer's disease, and pathological correlations with genotype.

Davidson Y, Gibbons L, Pritchard A, Hardicre J, Wren J, Tian J, Shi J, Stopford C, Julien C, Thompson J, Payton A, Thaker U, Hayes AJ, Iwatsubo T, Pickering-Brown SM, Pendleton N, Horan MA, Burns A, Purandare N, Lendon CL, Neary D, Snowden JS, Mann DM. Davidson Y, et al. J Neurol Neurosurg Psychiatry. 2006 Apr;77(4):515-7. doi: 10.1136/jnnp.2005.063917. J Neurol Neurosurg Psychiatry. 2006. PMID: 16543533 Free PMC article.

Imaging of amyloid plaques and cerebral glucose metabolism in semantic dementia and Alzheimer's disease.

Drzezga A, Grimmer T, Henriksen G, Stangier I, Perneczky R, Diehl-Schmid J, Mathis CA, Klunk WE, Price J, DeKosky S, Wester HJ, Schwaiger M, Kurz A. Drzezga A, et al. Neuroimage. 2008 Jan 15;39(2):619-33. doi: 10.1016/j.neuroimage.2007.09.020. Epub 2007 Sep 21. Neuroimage. 2008. PMID: 17962045

Apolipoprotein E genotype and the diagnostic accuracy of cerebrospinal fluid biomarkers for Alzheimer disease.

Lautner R, Palmqvist S, Mattsson N, Andreasson U, Wallin A, Pålsson E, Jakobsson J, Herukka SK, Owenius R, Olsson B, Hampel H, Rujescu D, Ewers M, Landén M, Minthon L, Blennow K, Zetterberg H, Hansson O; Alzheimer’s Disease Neuroimaging Initiative. Lautner R, et al. JAMA Psychiatry. 2014 Oct;71(10):1183-91. doi: 10.1001/jamapsychiatry.2014.1060. JAMA Psychiatry. 2014. PMID: 25162367

Effect of APOE ε4 genotype on amyloid-β, glucose metabolism, and gray matter volume in cognitively normal individuals and amnestic mild cognitive impairment.

Li W, Li R, Yan S, Zhao Z, Shan Y, Qi Z, Lu J; Alzheimer's Disease Neuroimaging Initiative. Li W, et al. Eur J Neurol. 2023 Mar;30(3):587-596. doi: 10.1111/ene.15656. Epub 2022 Dec 29. Eur J Neurol. 2023. PMID: 36448771 Free PMC article.

Association of sex and APOE ε4 with brain tau deposition and atrophy in older adults with Alzheimer's disease.

Yan S, Zheng C, Paranjpe MD, Li J, Benzinger TLS, Lu J, Zhou Y. Yan S, et al. Theranostics. 2020 Aug 21;10(23):10563-10572. doi: 10.7150/thno.48522. eCollection 2020. Theranostics. 2020. PMID: 32929366 Free PMC article.

Apolipoprotein E-epsilon4 alleles in cerebral amyloid angiopathy and cerebrovascular pathology associated with Alzheimer's disease.

Premkumar DR, Cohen DL, Hedera P, Friedland RP, Kalaria RN. Premkumar DR, et al. Am J Pathol. 1996 Jun;148(6):2083-95. Am J Pathol. 1996. PMID: 8669492 Free PMC article.

Differential effect of APOE genotype on amyloid load and glucose metabolism in AD dementia.

Ossenkoppele R, van der Flier WM, Zwan MD, Adriaanse SF, Boellaard R, Windhorst AD, Barkhof F, Lammertsma AA, Scheltens P, van Berckel BN. Ossenkoppele R, et al. Neurology. 2013 Jan 22;80(4):359-65. doi: 10.1212/WNL.0b013e31827f0889. Epub 2012 Dec 19. Neurology. 2013. PMID: 23255822

Profiles of β-Amyloid Peptides and Key Secretases in Brain Autopsy Samples Differ with Sex and APOE ε4 Status: Impact for Risk and Progression of Alzheimer Disease.

Nyarko JNK, Quartey MO, Pennington PR, Heistad RM, Dea D, Poirier J, Baker GB, Mousseau DD. Nyarko JNK, et al. Neuroscience. 2018 Mar 1;373:20-36. doi: 10.1016/j.neuroscience.2018.01.005. Epub 2018 Jan 11. Neuroscience. 2018. PMID: 29331531 Free article.

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