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Endogenous kappa opioid activation mediates stress-induced deficits in learning and memory.

Carey AN, Lyons AM, Shay CF, Dunton O, McLaughlin JP.

J Neurosci. 2009 Apr 1;29(13):4293-300. doi: 10.1523/JNEUROSCI.6146-08.2009.


The dysphoric component of stress is encoded by activation of the dynorphin kappa-opioid system.

Land BB, Bruchas MR, Lemos JC, Xu M, Melief EJ, Chavkin C.

J Neurosci. 2008 Jan 9;28(2):407-14. doi: 10.1523/JNEUROSCI.4458-07.2008.


Endogenous kappa-opioid mediation of stress-induced potentiation of ethanol-conditioned place preference and self-administration.

Sperling RE, Gomes SM, Sypek EI, Carey AN, McLaughlin JP.

Psychopharmacology (Berl). 2010 Jun;210(2):199-209. doi: 10.1007/s00213-010-1844-5. Epub 2010 Apr 17.


Social defeat stress-induced behavioral responses are mediated by the endogenous kappa opioid system.

McLaughlin JP, Li S, Valdez J, Chavkin TA, Chavkin C.

Neuropsychopharmacology. 2006 Jun;31(6):1241-8.


Kappa opioid receptor antagonism and prodynorphin gene disruption block stress-induced behavioral responses.

McLaughlin JP, Marton-Popovici M, Chavkin C.

J Neurosci. 2003 Jul 2;23(13):5674-83.


Stress-induced p38 mitogen-activated protein kinase activation mediates kappa-opioid-dependent dysphoria.

Bruchas MR, Land BB, Aita M, Xu M, Barot SK, Li S, Chavkin C.

J Neurosci. 2007 Oct 24;27(43):11614-23.


Stress-induced reinstatement of cocaine seeking is mediated by the kappa opioid system.

Redila VA, Chavkin C.

Psychopharmacology (Berl). 2008 Sep;200(1):59-70. doi: 10.1007/s00213-008-1122-y. Epub 2008 Jun 25.


Protracted withdrawal from ethanol and enhanced responsiveness stress: regulation via the dynorphin/kappa opioid receptor system.

Gillett K, Harshberger E, Valdez GR.

Alcohol. 2013 Aug;47(5):359-65. doi: 10.1016/j.alcohol.2013.05.001. Epub 2013 May 31.


Prodynorphin gene deficiency potentiates nalbuphine-induced behavioral sensitization and withdrawal syndrome in mice.

Shin EJ, Jang CG, Bing G, Park DH, Oh CH, Koo KH, Oh KW, Yamada K, Nabeshima T, Kim HC.

Drug Alcohol Depend. 2009 Sep 1;104(1-2):175-84. doi: 10.1016/j.drugalcdep.2009.05.015. Epub 2009 Jun 25.


Kappa Opioid Receptor-Induced Aversion Requires p38 MAPK Activation in VTA Dopamine Neurons.

Ehrich JM, Messinger DI, Knakal CR, Kuhar JR, Schattauer SS, Bruchas MR, Zweifel LS, Kieffer BL, Phillips PE, Chavkin C.

J Neurosci. 2015 Sep 16;35(37):12917-31. doi: 10.1523/JNEUROSCI.2444-15.2015.


Activation of the kappa opioid receptor in the dorsal raphe nucleus mediates the aversive effects of stress and reinstates drug seeking.

Land BB, Bruchas MR, Schattauer S, Giardino WJ, Aita M, Messinger D, Hnasko TS, Palmiter RD, Chavkin C.

Proc Natl Acad Sci U S A. 2009 Nov 10;106(45):19168-73. doi: 10.1073/pnas.0910705106. Epub 2009 Oct 28.


Dynorphins regulate the strength of social memory.

Bilkei-Gorzo A, Mauer D, Michel K, Zimmer A.

Neuropharmacology. 2014 Feb;77:406-13. doi: 10.1016/j.neuropharm.2013.10.023. Epub 2013 Nov 1.


Kappa-opioid system regulates the long-lasting behavioral adaptations induced by early-life exposure to methylphenidate.

Wiley MD, Poveromo LB, Antapasis J, Herrera CM, Bolaños Guzmán CA.

Neuropsychopharmacology. 2009 Apr;34(5):1339-50. doi: 10.1038/npp.2008.188. Epub 2008 Oct 15.


Stress-Induced Reinstatement of Nicotine Preference Requires Dynorphin/Kappa Opioid Activity in the Basolateral Amygdala.

Nygard SK, Hourguettes NJ, Sobczak GG, Carlezon WA, Bruchas MR.

J Neurosci. 2016 Sep 21;36(38):9937-48. doi: 10.1523/JNEUROSCI.0953-16.2016.


The macrocyclic tetrapeptide [D-Trp]CJ-15,208 produces short-acting κ opioid receptor antagonism in the CNS after oral administration.

Eans SO, Ganno ML, Reilley KJ, Patkar KA, Senadheera SN, Aldrich JV, McLaughlin JP.

Br J Pharmacol. 2013 May;169(2):426-36. doi: 10.1111/bph.12132.


Dissociable effects of kappa-opioid receptor activation on impulsive phenotypes in wistar rats.

Walker BM, Kissler JL.

Neuropsychopharmacology. 2013 Oct;38(11):2278-85. doi: 10.1038/npp.2013.129. Epub 2013 May 21.


Kappa opioid receptor activation of p38 MAPK is GRK3- and arrestin-dependent in neurons and astrocytes.

Bruchas MR, Macey TA, Lowe JD, Chavkin C.

J Biol Chem. 2006 Jun 30;281(26):18081-9. Epub 2006 Apr 28.


Investigation of the role of βarrestin2 in kappa opioid receptor modulation in a mouse model of pruritus.

Morgenweck J, Frankowski KJ, Prisinzano TE, Aubé J, Bohn LM.

Neuropharmacology. 2015 Dec;99:600-9. doi: 10.1016/j.neuropharm.2015.08.027. Epub 2015 Aug 25.

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