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Requirement for CD45 in fine-tuning mast cell responses mediated by different ligand-receptor systems.

Grochowy G, Hermiston ML, Kuhny M, Weiss A, Huber M.

Cell Signal. 2009 Aug;21(8):1277-86. doi: 10.1016/j.cellsig.2009.03.018. Epub 2009 Mar 27.


Dysregulated FcepsilonRI signaling and altered Fyn and SHIP activities in Lyn-deficient mast cells.

Hernandez-Hansen V, Smith AJ, Surviladze Z, Chigaev A, Mazel T, Kalesnikoff J, Lowell CA, Krystal G, Sklar LA, Wilson BS, Oliver JM.

J Immunol. 2004 Jul 1;173(1):100-12.


Differential Lyn-dependence of the SHIP1-deficient mast cell phenotype.

Nunes de Miranda SM, Wilhelm T, Huber M, Zorn CN.

Cell Commun Signal. 2016 May 20;14(1):12. doi: 10.1186/s12964-016-0135-0.


SH2 domain-containing phosphatase-2 protein-tyrosine phosphatase promotes Fc epsilon RI-induced activation of Fyn and Erk pathways leading to TNF alpha release from bone marrow-derived mast cells.

McPherson VA, Sharma N, Everingham S, Smith J, Zhu HH, Feng GS, Craig AW.

J Immunol. 2009 Oct 15;183(8):4940-7. doi: 10.4049/jimmunol.0900702. Epub 2009 Sep 28.


The Src family kinase Fgr is critical for activation of mast cells and IgE-mediated anaphylaxis in mice.

Lee JH, Kim JW, Kim DK, Kim HS, Park HJ, Park DK, Kim AR, Kim B, Beaven MA, Park KL, Kim YM, Choi WS.

J Immunol. 2011 Aug 15;187(4):1807-15. doi: 10.4049/jimmunol.1100296. Epub 2011 Jul 11.


PTPalpha activates Lyn and Fyn and suppresses Hck to negatively regulate FcepsilonRI-dependent mast cell activation and allergic responses.

Samayawardhena LA, Pallen CJ.

J Immunol. 2010 Nov 15;185(10):5993-6002. doi: 10.4049/jimmunol.1001261. Epub 2010 Oct 13.


Fyn kinase acts upstream of Shp2 and p38 mitogen-activated protein kinase to promote chemotaxis of mast cells towards stem cell factor.

Samayawardhena LA, Hu J, Stein PL, Craig AW.

Cell Signal. 2006 Sep;18(9):1447-54. Epub 2006 Jan 25.


Increased expression of genes linked to FcepsilonRI Signaling and to cytokine and chemokine production in Lyn-deficient mast cells.

Hernandez-Hansen V, Bard JD, Tarleton CA, Wilder JA, Lowell CA, Wilson BS, Oliver JM.

J Immunol. 2005 Dec 15;175(12):7880-8.


Transmembrane adaptor protein PAG/CBP is involved in both positive and negative regulation of mast cell signaling.

Draberova L, Bugajev V, Potuckova L, Halova I, Bambouskova M, Polakovicova I, Xavier RJ, Seed B, Draber P.

Mol Cell Biol. 2014 Dec 1;34(23):4285-300. doi: 10.1128/MCB.00983-14. Epub 2014 Sep 22.


Redundant and opposing functions of two tyrosine kinases, Btk and Lyn, in mast cell activation.

Kawakami Y, Kitaura J, Satterthwaite AB, Kato RM, Asai K, Hartman SE, Maeda-Yamamoto M, Lowell CA, Rawlings DJ, Witte ON, Kawakami T.

J Immunol. 2000 Aug 1;165(3):1210-9.


The Src family kinase Hck regulates mast cell activation by suppressing an inhibitory Src family kinase Lyn.

Hong H, Kitaura J, Xiao W, Horejsi V, Ra C, Lowell CA, Kawakami Y, Kawakami T.

Blood. 2007 Oct 1;110(7):2511-9. Epub 2007 May 18. Erratum in: Blood. 2008 Mar 15;111(6):3299.


DJ-1 regulates mast cell activation and IgE-mediated allergic responses.

Kim DK, Kim HS, Kim AR, Kim JH, Kim B, Noh G, Kim HS, Beaven MA, Kim YM, Choi WS.

J Allergy Clin Immunol. 2013 Jun;131(6):1653-62. doi: 10.1016/j.jaci.2012.10.012. Epub 2012 Nov 22.


Regulation of mast cell signaling through high-affinity IgE receptor by CD45 protein tyrosine phosphatase.

Murakami K, Sato S, Nagasawa S, Yamashita T.

Int Immunol. 2000 Feb;12(2):169-76.


A minor catalytic activity of Src family kinases is sufficient for maximal activation of mast cells via the high-affinity IgE receptor.

Poderycki M, Tomimori Y, Ando T, Xiao W, Maeda-Yamamoto M, Sauer K, Kawakami Y, Kawakami T.

J Immunol. 2010 Jan 1;184(1):84-93. doi: 10.4049/jimmunol.0901590. Epub 2009 Nov 30.


Balanced interactions between Lyn, the p85alpha regulatory subunit of class I(A) phosphatidylinositol-3-kinase, and SHIP are essential for mast cell growth and maturation.

Ma P, Vemula S, Munugalavadla V, Chen J, Sims E, Borneo J, Kondo T, Ramdas B, Mali RS, Li S, Hashino E, Takemoto C, Kapur R.

Mol Cell Biol. 2011 Oct;31(19):4052-62. doi: 10.1128/MCB.05750-11. Epub 2011 Jul 26.


Rapid and large amount of autocrine IL-3 production is responsible for mast cell survival by IgE in the absence of antigen.

Kohno M, Yamasaki S, Tybulewicz VL, Saito T.

Blood. 2005 Mar 1;105(5):2059-65. Epub 2004 Nov 12.


The role of Src family kinases in mast cell effector function.

Furumoto Y, Gomez G, Gonzalez-Espinosa C, Kovarova M, Odom S, Ryan JJ, Rivera J.

Novartis Found Symp. 2005;271:39-47; discussion 47-53, 95-9. Review.


Regulation of microtubule formation in activated mast cells by complexes of gamma-tubulin with Fyn and Syk kinases.

Sulimenko V, Dráberová E, Sulimenko T, Macurek L, Richterová V, Dráber P, Dráber P.

J Immunol. 2006 Jun 15;176(12):7243-53.


Dysregulation of Src family kinases in mast cells from epilepsy-resistant ASK versus epilepsy-prone EL mice.

Kitaura J, Kawakami Y, Maeda-Yamamoto M, Horejsi V, Kawakami T.

J Immunol. 2007 Jan 1;178(1):455-62.

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