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Items: 1 to 20 of 233

1.

Investigation of the functional role of tryptophan-22 in Escherichia coli dihydrofolate reductase by site-directed mutagenesis.

Warren MS, Brown KA, Farnum MF, Howell EE, Kraut J.

Biochemistry. 1991 Nov 19;30(46):11092-103.

PMID:
1932031
3.

Probing the functional role of phenylalanine-31 of Escherichia coli dihydrofolate reductase by site-directed mutagenesis.

Chen JT, Taira K, Tu CP, Benkovic SJ.

Biochemistry. 1987 Jun 30;26(13):4093-100.

PMID:
3307917
4.

Engineering specificity for folate into dihydrofolate reductase from Escherichia coli.

Posner BA, Li L, Bethell R, Tsuji T, Benkovic SJ.

Biochemistry. 1996 Feb 6;35(5):1653-63.

PMID:
8634297
5.

Nonadditivity of mutational effects at the folate binding site of Escherichia coli dihydrofolate reductase.

Huang Z, Wagner CR, Benkovic SJ.

Biochemistry. 1994 Sep 27;33(38):11576-85.

PMID:
7918371
6.

Construction of an altered proton donation mechanism in Escherichia coli dihydrofolate reductase.

Howell EE, Warren MS, Booth CL, Villafranca JE, Kraut J.

Biochemistry. 1987 Dec 29;26(26):8591-8.

PMID:
2894842
10.

The importance of loop region residues 40-46 in human dihydrofolate reductase as revealed by site-directed mutagenesis.

Tan XH, Huang SM, Ratnam M, Thompson PD, Freisheim JH.

J Biol Chem. 1990 May 15;265(14):8027-32.

11.
12.

Role of the conserved active site residue tryptophan-24 of human dihydrofolate reductase as revealed by mutagenesis.

Beard WA, Appleman JR, Huang SM, Delcamp TJ, Freisheim JH, Blakley RL.

Biochemistry. 1991 Feb 5;30(5):1432-40.

PMID:
1991124
13.

Effects of substitution of Thr63 by alanine on the structure and function of Lactobacillus casei dihydrofolate reductase.

Thomas JA, Arnold JR, Basran J, Andrews J, Roberts GC, Birdsall B, Feeney J.

Protein Eng. 1994 Jun;7(6):783-92.

PMID:
7937709
15.
16.

Probing the role of two hydrophobic active site residues in the human dihydrofolate reductase by site-directed mutagenesis.

Schweitzer BI, Srimatkandada S, Gritsman H, Sheridan R, Venkataraghavan R, Bertino JR.

J Biol Chem. 1989 Dec 5;264(34):20786-95.

18.

Interloop contacts modulate ligand cycling during catalysis by Escherichia coli dihydrofolate reductase.

Miller GP, Wahnon DC, Benkovic SJ.

Biochemistry. 2001 Jan 30;40(4):867-75.

PMID:
11170407
19.

Functional role of aspartic acid-27 in dihydrofolate reductase revealed by mutagenesis.

Howell EE, Villafranca JE, Warren MS, Oatley SJ, Kraut J.

Science. 1986 Mar 7;231(4742):1123-8.

PMID:
3511529
20.

Critical role of phenylalanine 34 of human dihydrofolate reductase in substrate and inhibitor binding and in catalysis.

Nakano T, Spencer HT, Appleman JR, Blakley RL.

Biochemistry. 1994 Aug 23;33(33):9945-52.

PMID:
8061003

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