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Genome-wide hypomethylation in head and neck cancer is more pronounced in HPV-negative tumors and is associated with genomic instability.

Richards KL, Zhang B, Baggerly KA, Colella S, Lang JC, Schuller DE, Krahe R.

PLoS One. 2009;4(3):e4941. doi: 10.1371/journal.pone.0004941. Epub 2009 Mar 18.


DNA global hypomethylation in squamous cell head and neck cancer associated with smoking, alcohol consumption and stage.

Smith IM, Mydlarz WK, Mithani SK, Califano JA.

Int J Cancer. 2007 Oct 15;121(8):1724-8.


Identification of human papillomavirus (HPV) 16 DNA integration and the ensuing patterns of methylation in HPV-associated head and neck squamous cell carcinoma cell lines.

Hatano T, Sano D, Takahashi H, Hyakusoku H, Isono Y, Shimada S, Sawakuma K, Takada K, Oikawa R, Watanabe Y, Yamamoto H, Itoh F, Myers JN, Oridate N.

Int J Cancer. 2017 Apr 1;140(7):1571-1580. doi: 10.1002/ijc.30589. Epub 2017 Jan 9.


Chromosomal instability associated with global DNA hypomethylation is associated with the initiation and progression of esophageal squamous cell carcinoma.

Kawano H, Saeki H, Kitao H, Tsuda Y, Otsu H, Ando K, Ito S, Egashira A, Oki E, Morita M, Oda Y, Maehara Y.

Ann Surg Oncol. 2014 Dec;21 Suppl 4:S696-702. doi: 10.1245/s10434-014-3818-z. Epub 2014 Jun 5.


Hypomethylation of retrotransposable elements correlates with genomic instability in non-small cell lung cancer.

Daskalos A, Nikolaidis G, Xinarianos G, Savvari P, Cassidy A, Zakopoulou R, Kotsinas A, Gorgoulis V, Field JK, Liloglou T.

Int J Cancer. 2009 Jan 1;124(1):81-7. doi: 10.1002/ijc.23849.


LINE-1 and Alu methylation patterns in lymph node metastases of head and neck cancers.

Kitkumthorn N, Keelawat S, Rattanatanyong P, Mutirangura A.

Asian Pac J Cancer Prev. 2012;13(9):4469-75.


Hypomethylation of LINE-1, and not centromeric SAT-α, is associated with centromeric instability in head and neck squamous cell carcinoma.

Martínez JG, Pérez-Escuredo J, Castro-Santos P, Marcos CA, Pendás JL, Fraga MF, Hermsen MA.

Cell Oncol (Dordr). 2012 Aug;35(4):259-67. doi: 10.1007/s13402-012-0085-5. Epub 2012 Jun 21.


Alu and LINE-1 hypomethylation is associated with HER2 enriched subtype of breast cancer.

Park SY, Seo AN, Jung HY, Gwak JM, Jung N, Cho NY, Kang GH.

PLoS One. 2014 Jun 27;9(6):e100429. doi: 10.1371/journal.pone.0100429. eCollection 2014.


Loss of epigenetic silencing in tumors preferentially affects primate-specific retroelements.

Szpakowski S, Sun X, Lage JM, Dyer A, Rubinstein J, Kowalski D, Sasaki C, Costa J, Lizardi PM.

Gene. 2009 Dec 15;448(2):151-67. doi: 10.1016/j.gene.2009.08.006. Epub 2009 Aug 21.


TMEM16A/ANO1 is differentially expressed in HPV-negative versus HPV-positive head and neck squamous cell carcinoma through promoter methylation.

Dixit R, Kemp C, Kulich S, Seethala R, Chiosea S, Ling S, Ha PK, Duvvuri U.

Sci Rep. 2015 Nov 13;5:16657. doi: 10.1038/srep16657.


Human papilloma virus (HPV) modulation of the HNSCC epigenome.

Stephen JK, Worsham MJ.

Methods Mol Biol. 2015;1238:369-79. doi: 10.1007/978-1-4939-1804-1_20.


Interplay between human papilloma virus infection and p53 gene alterations in head and neck squamous cell carcinoma of an Indian patient population.

Mitra S, Banerjee S, Misra C, Singh RK, Roy A, Sengupta A, Panda CK, Roychoudhury S.

J Clin Pathol. 2007 Sep;60(9):1040-7. Epub 2006 Nov 1.


Genetic patterns in head and neck cancers that contain or lack transcriptionally active human papillomavirus.

Braakhuis BJ, Snijders PJ, Keune WJ, Meijer CJ, Ruijter-Schippers HJ, Leemans CR, Brakenhoff RH.

J Natl Cancer Inst. 2004 Jul 7;96(13):998-1006.


LINE-1 hypomethylation in cancer is highly variable and inversely correlated with microsatellite instability.

Estécio MR, Gharibyan V, Shen L, Ibrahim AE, Doshi K, He R, Jelinek J, Yang AS, Yan PS, Huang TH, Tajara EH, Issa JP.

PLoS One. 2007 May 2;2(5):e399.


LINE-1 hypomethylation is associated with a poor prognosis among patients with curatively resected esophageal squamous cell carcinoma.

Iwagami S, Baba Y, Watanabe M, Shigaki H, Miyake K, Ishimoto T, Iwatsuki M, Sakamaki K, Ohashi Y, Baba H.

Ann Surg. 2013 Mar;257(3):449-55. doi: 10.1097/SLA.0b013e31826d8602.


LINE-1 hypomethylation, DNA copy number alterations, and CDK6 amplification in esophageal squamous cell carcinoma.

Baba Y, Watanabe M, Murata A, Shigaki H, Miyake K, Ishimoto T, Iwatsuki M, Iwagami S, Yoshida N, Oki E, Sakamaki K, Nakao M, Baba H.

Clin Cancer Res. 2014 Mar 1;20(5):1114-24. doi: 10.1158/1078-0432.CCR-13-1645. Epub 2014 Jan 14.


The relationship between global methylation level, loss of heterozygosity, and microsatellite instability in sporadic colorectal cancer.

Matsuzaki K, Deng G, Tanaka H, Kakar S, Miura S, Kim YS.

Clin Cancer Res. 2005 Dec 15;11(24 Pt 1):8564-9.


Global DNA methylation level in whole blood as a biomarker in head and neck squamous cell carcinoma.

Hsiung DT, Marsit CJ, Houseman EA, Eddy K, Furniss CS, McClean MD, Kelsey KT.

Cancer Epidemiol Biomarkers Prev. 2007 Jan;16(1):108-14.


Molecular heterogeneity of head and neck squamous cell carcinoma defined by next-generation sequencing.

Zhang P, Mirani N, Baisre A, Fernandes H.

Am J Pathol. 2014 May;184(5):1323-30. doi: 10.1016/j.ajpath.2014.01.028.


Protein expression and promoter methylation of the candidate biomarker TCF21 in head and neck squamous cell carcinoma.

Weiss D, Stockmann C, Schrödter K, Rudack C.

Cell Oncol (Dordr). 2013 Jun;36(3):213-24. doi: 10.1007/s13402-013-0129-5. Epub 2013 Mar 26.


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