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Items: 1 to 20 of 138


Tow (Target of Wingless), a novel repressor of the Hedgehog pathway in Drosophila.

Ayers KL, Rodriguez R, Gallet A, Ruel L, Thérond P.

Dev Biol. 2009 May 15;329(2):280-93. doi: 10.1016/j.ydbio.2009.02.037. Epub 2009 Mar 10.


Regulation of smoothened by Drosophila G-protein-coupled receptor kinases.

Cheng S, Maier D, Neubueser D, Hipfner DR.

Dev Biol. 2010 Jan 1;337(1):99-109. doi: 10.1016/j.ydbio.2009.10.014. Epub 2009 Oct 20.


The Drosophila smoothened gene encodes a seven-pass membrane protein, a putative receptor for the hedgehog signal.

Alcedo J, Ayzenzon M, Von Ohlen T, Noll M, Hooper JE.

Cell. 1996 Jul 26;86(2):221-32.


G protein Galphai functions immediately downstream of Smoothened in Hedgehog signalling.

Ogden SK, Fei DL, Schilling NS, Ahmed YF, Hwa J, Robbins DJ.

Nature. 2008 Dec 18;456(7224):967-70. doi: 10.1038/nature07459.


Sonic hedgehog signaling by the patched-smoothened receptor complex.

Murone M, Rosenthal A, de Sauvage FJ.

Curr Biol. 1999 Jan 28;9(2):76-84.


Patched represses the Hedgehog signalling pathway by promoting modification of the Smoothened protein.

Ingham PW, Nystedt S, Nakano Y, Brown W, Stark D, van den Heuvel M, Taylor AM.

Curr Biol. 2000 Oct 19;10(20):1315-8.


Mutations in the sterol-sensing domain of Patched suggest a role for vesicular trafficking in Smoothened regulation.

Strutt H, Thomas C, Nakano Y, Stark D, Neave B, Taylor AM, Ingham PW.

Curr Biol. 2001 Apr 17;11(8):608-13. Erratum in: Curr Biol 2001 Jul 24;11(14):1153.


Evidence for a novel feedback loop in the Hedgehog pathway involving Smoothened and Fused.

Claret S, Sanial M, Plessis A.

Curr Biol. 2007 Aug 7;17(15):1326-33. Epub 2007 Jul 19.


Functional domains and sub-cellular distribution of the Hedgehog transducing protein Smoothened in Drosophila.

Nakano Y, Nystedt S, Shivdasani AA, Strutt H, Thomas C, Ingham PW.

Mech Dev. 2004 Jun;121(6):507-18.


Role of lipid metabolism in smoothened derepression in hedgehog signaling.

Yavari A, Nagaraj R, Owusu-Ansah E, Folick A, Ngo K, Hillman T, Call G, Rohatgi R, Scott MP, Banerjee U.

Dev Cell. 2010 Jul 20;19(1):54-65. doi: 10.1016/j.devcel.2010.06.007.


Smoothened oligomerization/higher order clustering in lipid rafts is essential for high Hedgehog activity transduction.

Shi D, Lv X, Zhang Z, Yang X, Zhou Z, Zhang L, Zhao Y.

J Biol Chem. 2013 May 3;288(18):12605-14. doi: 10.1074/jbc.M112.399477. Epub 2013 Mar 26.


Dual roles for patched in sequestering and transducing Hedgehog.

Chen Y, Struhl G.

Cell. 1996 Nov 1;87(3):553-63.


Cloning of a mouse smoothened cDNA and expression patterns of hedgehog signalling molecules during chondrogenesis and cartilage differentiation in clonal mouse EC cells, ATDC5.

Akiyama H, Shigeno C, Hiraki Y, Shukunami C, Kohno H, Akagi M, Konishi J, Nakamura T.

Biochem Biophys Res Commun. 1997 Jun 9;235(1):142-7.


Cilium-independent regulation of Gli protein function by Sufu in Hedgehog signaling is evolutionarily conserved.

Chen MH, Wilson CW, Li YJ, Law KK, Lu CS, Gacayan R, Zhang X, Hui CC, Chuang PT.

Genes Dev. 2009 Aug 15;23(16):1910-28. doi: 10.1101/gad.1794109.


Altered localization of Drosophila Smoothened protein activates Hedgehog signal transduction.

Zhu AJ, Zheng L, Suyama K, Scott MP.

Genes Dev. 2003 May 15;17(10):1240-52. Epub 2003 May 2.

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