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Evidence that phosphorylation of iron regulatory protein 1 at Serine 138 destabilizes the [4Fe-4S] cluster in cytosolic aconitase by enhancing 4Fe-3Fe cycling.

Deck KM, Vasanthakumar A, Anderson SA, Goforth JB, Kennedy MC, Antholine WE, Eisenstein RS.

J Biol Chem. 2009 May 8;284(19):12701-9. doi: 10.1074/jbc.M807717200. Epub 2009 Mar 6.


Detection of a [3Fe-4S] cluster intermediate of cytosolic aconitase in yeast expressing iron regulatory protein 1. Insights into the mechanism of Fe-S cluster cycling.

Brown NM, Kennedy MC, Antholine WE, Eisenstein RS, Walden WE.

J Biol Chem. 2002 Mar 1;277(9):7246-54. Epub 2001 Dec 13.


Novel role of phosphorylation in Fe-S cluster stability revealed by phosphomimetic mutations at Ser-138 of iron regulatory protein 1.

Brown NM, Anderson SA, Steffen DW, Carpenter TB, Kennedy MC, Walden WE, Eisenstein RS.

Proc Natl Acad Sci U S A. 1998 Dec 22;95(26):15235-40.


A phosphomimetic mutation at Ser-138 renders iron regulatory protein 1 sensitive to iron-dependent degradation.

Fillebeen C, Chahine D, Caltagirone A, Segal P, Pantopoulos K.

Mol Cell Biol. 2003 Oct;23(19):6973-81.


A synergistic role of IRP1 and FBXL5 proteins in coordinating iron metabolism during cell proliferation.

Johnson NB, Deck KM, Nizzi CP, Eisenstein RS.

J Biol Chem. 2017 Sep 22;292(38):15976-15989. doi: 10.1074/jbc.M117.785741. Epub 2017 Aug 2.


The iron-sulfur cluster of iron regulatory protein 1 modulates the accessibility of RNA binding and phosphorylation sites.

Schalinske KL, Anderson SA, Tuazon PT, Chen OS, Kennedy MC, Eisenstein RS.

Biochemistry. 1997 Apr 1;36(13):3950-8.


Peroxynitrite and nitric oxide differently target the iron-sulfur cluster and amino acid residues of human iron regulatory protein 1.

Soum E, Brazzolotto X, Goussias C, Bouton C, Moulis JM, Mattioli TA, Drapier JC.

Biochemistry. 2003 Jul 1;42(25):7648-54.


IRP1 Ser-711 is a phosphorylation site, critical for regulation of RNA-binding and aconitase activities.

Fillebeen C, Caltagirone A, Martelli A, Moulis JM, Pantopoulos K.

Biochem J. 2005 May 15;388(Pt 1):143-50.


Expression and biochemical characterization of iron regulatory proteins 1 and 2 in Saccharomyces cerevisiae.

Phillips JD, Guo B, Yu Y, Brown FM, Leibold EA.

Biochemistry. 1996 Dec 10;35(49):15704-14.


Selective inhibition of the citrate-to-isocitrate reaction of cytosolic aconitase by phosphomimetic mutation of serine-711.

Pitula JS, Deck KM, Clarke SL, Anderson SA, Vasanthakumar A, Eisenstein RS.

Proc Natl Acad Sci U S A. 2004 Jul 27;101(30):10907-12. Epub 2004 Jul 19.


A novel eukaryotic factor for cytosolic Fe-S cluster assembly.

Roy A, Solodovnikova N, Nicholson T, Antholine W, Walden WE.

EMBO J. 2003 Sep 15;22(18):4826-35.


Redox modulation of iron regulatory proteins by peroxynitrite.

Bouton C, Hirling H, Drapier JC.

J Biol Chem. 1997 Aug 8;272(32):19969-75.


Recycling of RNA binding iron regulatory protein 1 into an aconitase after nitric oxide removal depends on mitochondrial ATP.

Bouton C, Chauveau MJ, Lazereg S, Drapier JC.

J Biol Chem. 2002 Aug 23;277(34):31220-7. Epub 2002 May 30.


Mössbauer studies of aconitase. Substrate and inhibitor binding, reaction intermediates, and hyperfine interactions of reduced 3Fe and 4Fe clusters.

Kent TA, Emptage MH, Merkle H, Kennedy MC, Beinert H, Münck E.

J Biol Chem. 1985 Jun 10;260(11):6871-81.


Effect of cysteine to serine mutations on the properties of the [4Fe-4S] center in Escherichia coli fumarate reductase.

Kowal AT, Werth MT, Manodori A, Cecchini G, Schröder I, Gunsalus RP, Johnson MK.

Biochemistry. 1995 Sep 26;34(38):12284-93.


Iron-responsive degradation of iron-regulatory protein 1 does not require the Fe-S cluster.

Clarke SL, Vasanthakumar A, Anderson SA, Pondarré C, Koh CM, Deck KM, Pitula JS, Epstein CJ, Fleming MD, Eisenstein RS.

EMBO J. 2006 Feb 8;25(3):544-53. Epub 2006 Jan 19.

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