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Items: 1 to 20 of 226

1.

Simple strategy of reactivation of a partially inactivated penicillin g acylase biocatalyst in organic solvent and its impact on the synthesis of beta-lactam antibiotics.

Romero O, Vergara J, Fernández-Lafuente R, Guisán JM, Illanes A, Wilson L.

Biotechnol Bioeng. 2009 Jun 15;103(3):472-9. doi: 10.1002/bit.22264.

PMID:
19253933
2.

Synthesis of cephalexin in aqueous medium with carrier-bound and carrier-free penicillin acylase biocatalysts.

Illanes A, Wilson L, Aguirre C.

Appl Biochem Biotechnol. 2009 Apr;157(1):98-110. doi: 10.1007/s12010-008-8255-7. Epub 2008 Jul 10.

PMID:
18618085
3.

Crosslinked penicillin acylase aggregates for synthesis of beta-lactam antibiotics in organic medium.

Illanes A, Wilson L, Caballero E, Fernández-Lafuente R, Guisán JM.

Appl Biochem Biotechnol. 2006 Jun;133(3):189-202.

PMID:
16720900
4.
5.

Encapsulation of crosslinked penicillin G acylase aggregates in lentikats: evaluation of a novel biocatalyst in organic media.

Wilson L, Illanes A, Pessela BC, Abian O, Fernández-Lafuente R, Guisán JM.

Biotechnol Bioeng. 2004 Jun 5;86(5):558-62.

PMID:
15129439
6.

Enhanced production of 6-aminopenicillanic acid in aqueous methyl isobutyl ketone system with immobilized penicillin G acylase.

Fang SG, Qiang T, Liu RJ, Xu XM, Zhang YW.

Prep Biochem Biotechnol. 2010;40(1):38-45. doi: 10.1080/10826060903389489.

PMID:
20024793
7.

Enzymatic synthesis of beta-lactam antibiotics using penicillin-G acylase in frozen media.

van Langen LM, de Vroom E, van Rantwijk F, Sheldon R.

FEBS Lett. 1999 Jul 30;456(1):89-92.

8.

Cross-linked enzyme aggregates: a simple and effective method for the immobilization of penicillin acylase.

Cao L, van Rantwijk F, Sheldon RA.

Org Lett. 2000 May 18;2(10):1361-4.

PMID:
10814447
9.

Effect of internal diffusional restrictions on the hydrolysis of penicillin G: reactor performance and specific productivity of 6-APA with immobilized penicillin acylase.

Valencia P, Flores S, Wilson L, Illanes A.

Appl Biochem Biotechnol. 2011 Sep;165(2):426-41. doi: 10.1007/s12010-011-9262-7. Epub 2011 Apr 20.

PMID:
21505803
10.

Improved reactivation of immobilized-stabilized lipase from Thermomyces lanuginosus by its coating with highly hydrophilic polymers.

Rodrigues RC, Bolivar JM, Volpato G, Filice M, Godoy C, Fernandez-Lafuente R, Guisan JM.

J Biotechnol. 2009 Oct 26;144(2):113-9. doi: 10.1016/j.jbiotec.2009.09.002. Epub 2009 Sep 6.

PMID:
19737586
11.

Co-aggregation of penicillin g acylase and polyionic polymers: an easy methodology to prepare enzyme biocatalysts stable in organic media.

Wilson L, Illanes A, Abián O, Pessela BC, Fernández-Lafuente R, Guisán JM.

Biomacromolecules. 2004 May-Jun;5(3):852-7.

PMID:
15132672
12.

Improved specific productivity in cephalexin synthesis by immobilized PGA in silica magnetic micro-particles.

Bernardino SM, Fernandes P, Fonseca LP.

Biotechnol Bioeng. 2010 Dec 1;107(5):753-62. doi: 10.1002/bit.22867.

PMID:
20632377
13.

Optimization of yield in kinetically controlled synthesis of ampicillin with immobilized penicillin acylase in organic media.

Illanes A, Anjarí S, Arrieta R, Aguirre C.

Appl Biochem Biotechnol. 2002 Mar;97(3):165-79.

PMID:
11998841
14.

Enzyme reaction engineering: synthesis of antibiotics catalysed by stabilized penicillin G acylase in the presence of organic cosolvents.

Fernandez-Lafuente R, Rosell CM, Guisán JM.

Enzyme Microb Technol. 1991 Nov;13(11):898-905.

PMID:
1368000
15.

Use of aqueous two-phase systems for in situ extraction of water soluble antibiotics during their synthesis by enzymes immobilized on porous supports.

Hernandez-Justiz O, Fernandez-Lafuente R, Terreni M, Guisan JM.

Biotechnol Bioeng. 1998 Jul 5;59(1):73-9.

PMID:
10099316
16.

Kinetics of beta-lactam antibiotics synthesis by penicillin G acylase (PGA) from the viewpoint of the industrial enzymatic reactor optimization.

Giordano RC, Ribeiro MP, Giordano RL.

Biotechnol Adv. 2006 Jan-Feb;24(1):27-41. Epub 2005 Jun 28. Review.

PMID:
15990267
18.

Penicillin G acylase from Achromobacter sp. CCM 4824 : an efficient biocatalyst for syntheses of beta-lactam antibiotics under conditions employed in large-scale processes.

Bečka S, Štěpánek V, Vyasarayani RW, Grulich M, Maršálek J, Plháčková K, Dobišová M, Marešová H, Plačková M, Valešová R, Palyzová A, Datla A, Ashar TK, Kyslík P.

Appl Microbiol Biotechnol. 2014 Feb;98(3):1195-203. doi: 10.1007/s00253-013-4945-3. Epub 2013 May 15. Erratum in: Appl Microbiol Biotechnol. 2014 Dec;98(23):9889.

PMID:
23674150
19.

Dynamic reaction design of enzymic biotransformations in organic media: equilibrium-controlled synthesis of antibiotics by penicillin G acylase.

Fernandez-Lafuente R, Rosell CM, Guisan JM.

Biotechnol Appl Biochem. 1996 Oct;24 ( Pt 2):139-43.

PMID:
8865605
20.

Characterization and use of a penicillin acylase biocatalyst.

Ospina SS, Lopez-Munguia A, Gonzalez RL, Quintero R.

J Chem Technol Biotechnol. 1992;53(2):205-14.

PMID:
1368013

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