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hBub1 deficiency triggers a novel p53 mediated early apoptotic checkpoint pathway in mitotic spindle damaged cells.

Gao F, Ponte JF, Papageorgis P, Levy M, Ozturk S, Lambert AW, Pan H, Chinnappan D, Cheng KH, Thiagalingam A, Abdolmaleky HM, Thiagalingam S.

Cancer Biol Ther. 2009 Apr;8(7):627-35. Epub 2009 Apr 22.


hBub1 negatively regulates p53 mediated early cell death upon mitotic checkpoint activation.

Gao F, Ponte JF, Levy M, Papageorgis P, Cook NM, Ozturk S, Lambert AW, Thiagalingam A, Abdolmaleky HM, Sullivan BA, Thiagalingam S.

Cancer Biol Ther. 2009 Apr;8(7):548-56. Epub 2009 Apr 22.


MAD2 depletion triggers premature cellular senescence in human primary fibroblasts by activating a p53 pathway preventing aneuploid cells propagation.

Lentini L, Barra V, Schillaci T, Di Leonardo A.

J Cell Physiol. 2012 Sep;227(9):3324-32. doi: 10.1002/jcp.24030.


p31comet Induces cellular senescence through p21 accumulation and Mad2 disruption.

Yun M, Han YH, Yoon SH, Kim HY, Kim BY, Ju YJ, Kang CM, Jang SH, Chung HY, Lee SJ, Cho MH, Yoon G, Park GH, Kim SH, Lee KH.

Mol Cancer Res. 2009 Mar;7(3):371-82. doi: 10.1158/1541-7786.MCR-08-0056. Epub 2009 Mar 10.


RNAi mediated acute depletion of retinoblastoma protein (pRb) promotes aneuploidy in human primary cells via micronuclei formation.

Amato A, Lentini L, Schillaci T, Iovino F, Di Leonardo A.

BMC Cell Biol. 2009 Nov 2;10:79. doi: 10.1186/1471-2121-10-79.


Hormone-induced chromosomal instability in p53-null mammary epithelium.

Pati D, Haddad BR, Haegele A, Thompson H, Kittrell FS, Shepard A, Montagna C, Zhang N, Ge G, Otta SK, McCarthy M, Ullrich RL, Medina D.

Cancer Res. 2004 Aug 15;64(16):5608-16.


p53 activation in response to mitotic spindle damage requires signaling via BubR1-mediated phosphorylation.

Ha GH, Baek KH, Kim HS, Jeong SJ, Kim CM, McKeon F, Lee CW.

Cancer Res. 2007 Aug 1;67(15):7155-64.


Overexpression of the mitotic spindle assembly checkpoint genes hBUB1, hBUBR1 and hMAD2 in thyroid carcinomas with aggressive nature.

Wada N, Yoshida A, Miyagi Y, Yamamoto T, Nakayama H, Suganuma N, Matsuzu K, Masudo K, Hirakawa S, Rino Y, Masuda M, Imada T.

Anticancer Res. 2008 Jan-Feb;28(1A):139-44.


ECRG2 disruption leads to centrosome amplification and spindle checkpoint defects contributing chromosome instability.

Cheng X, Shen Z, Yang J, Lu SH, Cui Y.

J Biol Chem. 2008 Feb 29;283(9):5888-98. Epub 2007 Dec 27.


Genetic and transcriptional analysis of spindle checkpoint genes in bone marrow failure patients.

Yamaguchi H, Aridgides LJ, Zeng W, Osgood C, Young NS, Liu JM.

Blood Cells Mol Dis. 2003 May-Jun;30(3):307-11.


Mathematical model of a network of interaction between p53 and Bcl-2 during genotoxic-induced apoptosis.

Dogu Y, Díaz J.

Biophys Chem. 2009 Jul;143(1-2):44-54. doi: 10.1016/j.bpc.2009.03.012. Epub 2009 Apr 5.


No PUMA, no death: implications for p53-dependent apoptosis.

Yu J, Zhang L.

Cancer Cell. 2003 Oct;4(4):248-9. Review.


Human Bub1: a putative spindle checkpoint kinase closely linked to cell proliferation.

Ouyang B, Lan Z, Meadows J, Pan H, Fukasawa K, Li W, Dai W.

Cell Growth Differ. 1998 Oct;9(10):877-85.


Loss of histone deacetylase 4 causes segregation defects during mitosis of p53-deficient human tumor cells.

Cadot B, Brunetti M, Coppari S, Fedeli S, de Rinaldis E, Dello Russo C, Gallinari P, De Francesco R, Steinkühler C, Filocamo G.

Cancer Res. 2009 Aug 1;69(15):6074-82. doi: 10.1158/0008-5472.CAN-08-2796. Epub 2009 Jul 21.


p53 deficiency and defective mitotic checkpoint in proliferating T lymphocytes increase chromosomal instability through aberrant exit from mitotic arrest.

Baek KH, Shin HJ, Yoo JK, Cho JH, Choi YH, Sung YC, McKeon F, Lee CW.

J Leukoc Biol. 2003 Jun;73(6):850-61.


Frequent impairment of the spindle assembly checkpoint in hepatocellular carcinoma.

Saeki A, Tamura S, Ito N, Kiso S, Matsuda Y, Yabuuchi I, Kawata S, Matsuzawa Y.

Cancer. 2002 Apr 1;94(7):2047-54.


MAD2DeltaC induces aneuploidy and promotes anchorage-independent growth in human prostate epithelial cells.

To-Ho KW, Cheung HW, Ling MT, Wong YC, Wang X.

Oncogene. 2008 Jan 10;27(3):347-57. Epub 2007 Jul 9.


A requirement for breast-cancer-associated gene 1 (BRCA1) in the spindle checkpoint.

Wang RH, Yu H, Deng CX.

Proc Natl Acad Sci U S A. 2004 Dec 7;101(49):17108-13. Epub 2004 Nov 24.

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