Format
Sort by
Items per page

Send to

Choose Destination

Links from PubMed

Items: 1 to 20 of 123

1.

The human CDK8 subcomplex is a molecular switch that controls Mediator coactivator function.

Knuesel MT, Meyer KD, Bernecky C, Taatjes DJ.

Genes Dev. 2009 Feb 15;23(4):439-51. doi: 10.1101/gad.1767009.

2.

The human CDK8 subcomplex is a histone kinase that requires Med12 for activity and can function independently of mediator.

Knuesel MT, Meyer KD, Donner AJ, Espinosa JM, Taatjes DJ.

Mol Cell Biol. 2009 Feb;29(3):650-61. doi: 10.1128/MCB.00993-08. Epub 2008 Dec 1.

3.

Cyclin-dependent kinase 8 positively cooperates with Mediator to promote thyroid hormone receptor-dependent transcriptional activation.

Belakavadi M, Fondell JD.

Mol Cell Biol. 2010 May;30(10):2437-48. doi: 10.1128/MCB.01541-09. Epub 2010 Mar 15.

4.

Genome-wide location of the coactivator mediator: Binding without activation and transient Cdk8 interaction on DNA.

Andrau JC, van de Pasch L, Lijnzaad P, Bijma T, Koerkamp MG, van de Peppel J, Werner M, Holstege FC.

Mol Cell. 2006 Apr 21;22(2):179-92.

5.

A kinase subunit of the human mediator complex, CDK8, positively regulates transcriptional activation.

Furumoto T, Tanaka A, Ito M, Malik S, Hirose Y, Hanaoka F, Ohkuma Y.

Genes Cells. 2007 Jan;12(1):119-32.

6.

Cyclin-dependent kinase 8 module expression profiling reveals requirement of mediator subunits 12 and 13 for transcription of Serpent-dependent innate immunity genes in Drosophila.

Kuuluvainen E, Hakala H, Havula E, Sahal Estimé M, Rämet M, Hietakangas V, Mäkelä TP.

J Biol Chem. 2014 Jun 6;289(23):16252-61. doi: 10.1074/jbc.M113.541904. Epub 2014 Apr 28.

7.

The cyclin-dependent kinase 8 module sterically blocks Mediator interactions with RNA polymerase II.

Elmlund H, Baraznenok V, Lindahl M, Samuelsen CO, Koeck PJ, Holmberg S, Hebert H, Gustafsson CM.

Proc Natl Acad Sci U S A. 2006 Oct 24;103(43):15788-93. Epub 2006 Oct 16.

8.

A genome-wide RNA interference screen identifies a differential role of the mediator CDK8 module subunits for GATA/ RUNX-activated transcription in Drosophila.

Gobert V, Osman D, Bras S, Augé B, Boube M, Bourbon HM, Horn T, Boutros M, Haenlin M, Waltzer L.

Mol Cell Biol. 2010 Jun;30(11):2837-48. doi: 10.1128/MCB.01625-09. Epub 2010 Apr 5.

9.

Cooperative activity of cdk8 and GCN5L within Mediator directs tandem phosphoacetylation of histone H3.

Meyer KD, Donner AJ, Knuesel MT, York AG, Espinosa JM, Taatjes DJ.

EMBO J. 2008 May 21;27(10):1447-57. doi: 10.1038/emboj.2008.78. Epub 2008 Apr 17.

11.

TFIIH is negatively regulated by cdk8-containing mediator complexes.

Akoulitchev S, Chuikov S, Reinberg D.

Nature. 2000 Sep 7;407(6800):102-6.

PMID:
10993082
12.

Mediator kinase module and human tumorigenesis.

Clark AD, Oldenbroek M, Boyer TG.

Crit Rev Biochem Mol Biol. 2015;50(5):393-426. doi: 10.3109/10409238.2015.1064854. Epub 2015 Jul 16. Review.

13.

Distinct roles for Mediator Cdk8 module subunits in Drosophila development.

Loncle N, Boube M, Joulia L, Boschiero C, Werner M, Cribbs DL, Bourbon HM.

EMBO J. 2007 Feb 21;26(4):1045-54. Epub 2007 Feb 8.

14.

Suppression of Mediator is regulated by Cdk8-dependent Grr1 turnover of the Med3 coactivator.

Gonzalez D, Hamidi N, Del Sol R, Benschop JJ, Nancy T, Li C, Francis L, Tzouros M, Krijgsveld J, Holstege FC, Conlan RS.

Proc Natl Acad Sci U S A. 2014 Feb 18;111(7):2500-5. doi: 10.1073/pnas.1307525111. Epub 2014 Feb 3.

15.

Fine-tuning of histone H3 Lys4 methylation during pseudohyphal differentiation by the CDK submodule of RNA polymerase II.

Law MJ, Ciccaglione K.

Genetics. 2015 Feb;199(2):435-53. doi: 10.1534/genetics.114.172841. Epub 2014 Dec 1.

16.

The SCF-Fbw7 ubiquitin ligase degrades MED13 and MED13L and regulates CDK8 module association with Mediator.

Davis MA, Larimore EA, Fissel BM, Swanger J, Taatjes DJ, Clurman BE.

Genes Dev. 2013 Jan 15;27(2):151-6. doi: 10.1101/gad.207720.112. Epub 2013 Jan 15.

17.

Mediator cyclin-dependent kinases upregulate transcription of inflammatory genes in cooperation with NF-κB and C/EBPβ on stimulation of Toll-like receptor 9.

Yamamoto S, Hagihara T, Horiuchi Y, Okui A, Wani S, Yoshida T, Inoue T, Tanaka A, Ito T, Hirose Y, Ohkuma Y.

Genes Cells. 2017 Mar;22(3):265-276. doi: 10.1111/gtc.12475. Epub 2017 Feb 2.

PMID:
28151579
18.

Mediator can regulate mitotic entry and direct periodic transcription in fission yeast.

Banyai G, Lopez MD, Szilagyi Z, Gustafsson CM.

Mol Cell Biol. 2014 Nov;34(21):4008-18. doi: 10.1128/MCB.00819-14. Epub 2014 Aug 25.

19.

Mutation analysis of components of the Mediator kinase module in MED12 mutation-negative uterine leiomyomas.

Mäkinen N, Heinonen HR, Sjöberg J, Taipale J, Vahteristo P, Aaltonen LA.

Br J Cancer. 2014 Apr 29;110(9):2246-9. doi: 10.1038/bjc.2014.138. Epub 2014 Mar 18.

20.

Mediator complex recruits epigenetic regulators via its two cyclin-dependent kinase subunits to repress transcription of immune response genes.

Tsutsui T, Fukasawa R, Shinmyouzu K, Nakagawa R, Tobe K, Tanaka A, Ohkuma Y.

J Biol Chem. 2013 Jul 19;288(29):20955-65. doi: 10.1074/jbc.M113.486746. Epub 2013 Jun 9.

Supplemental Content

Support Center