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Items: 1 to 20 of 781

1.

A quantitative analysis of transglutaminase 2-mediated deamidation of gluten peptides: implications for the T-cell response in celiac disease.

Dørum S, Qiao SW, Sollid LM, Fleckenstein B.

J Proteome Res. 2009 Apr;8(4):1748-55. doi: 10.1021/pr800960n.

PMID:
19239248
2.

Gliadin T cell epitope selection by tissue transglutaminase in celiac disease. Role of enzyme specificity and pH influence on the transamidation versus deamidation process.

Fleckenstein B, Molberg Ø, Qiao SW, Schmid DG, von der Mülbe F, Elgstøen K, Jung G, Sollid LM.

J Biol Chem. 2002 Sep 13;277(37):34109-16. Epub 2002 Jul 1.

3.

The preferred substrates for transglutaminase 2 in a complex wheat gluten digest are Peptide fragments harboring celiac disease T-cell epitopes.

Dørum S, Arntzen MØ, Qiao SW, Holm A, Koehler CJ, Thiede B, Sollid LM, Fleckenstein B.

PLoS One. 2010 Nov 19;5(11):e14056. doi: 10.1371/journal.pone.0014056.

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Celiac lesion T cells recognize epitopes that cluster in regions of gliadins rich in proline residues.

Arentz-Hansen H, McAdam SN, Molberg Ø, Fleckenstein B, Lundin KE, Jørgensen TJ, Jung G, Roepstorff P, Sollid LM.

Gastroenterology. 2002 Sep;123(3):803-9.

PMID:
12198706
6.

Structure of celiac disease-associated HLA-DQ8 and non-associated HLA-DQ9 alleles in complex with two disease-specific epitopes.

Moustakas AK, van de Wal Y, Routsias J, Kooy YM, van Veelen P, Drijfhout JW, Koning F, Papadopoulos GK.

Int Immunol. 2000 Aug;12(8):1157-66.

7.

The intestinal T cell response to alpha-gliadin in adult celiac disease is focused on a single deamidated glutamine targeted by tissue transglutaminase.

Arentz-Hansen H, Körner R, Molberg O, Quarsten H, Vader W, Kooy YM, Lundin KE, Koning F, Roepstorff P, Sollid LM, McAdam SN.

J Exp Med. 2000 Feb 21;191(4):603-12.

8.

T cells from celiac disease lesions recognize gliadin epitopes deamidated in situ by endogenous tissue transglutaminase.

Molberg O, McAdam S, Lundin KE, Kristiansen C, Arentz-Hansen H, Kett K, Sollid LM.

Eur J Immunol. 2001 May;31(5):1317-23.

9.
10.

Identification of a gliadin T-cell epitope in coeliac disease: general importance of gliadin deamidation for intestinal T-cell recognition.

Sjöström H, Lundin KE, Molberg O, Körner R, McAdam SN, Anthonsen D, Quarsten H, Norén O, Roepstorff P, Thorsby E, Sollid LM.

Scand J Immunol. 1998 Aug;48(2):111-5.

11.

Tissue transglutaminase-mediated formation and cleavage of histamine-gliadin complexes: biological effects and implications for celiac disease.

Qiao SW, Piper J, Haraldsen G, Oynebråten I, Fleckenstein B, Molberg O, Khosla C, Sollid LM.

J Immunol. 2005 Feb 1;174(3):1657-63.

12.

Antigen presentation to celiac lesion-derived T cells of a 33-mer gliadin peptide naturally formed by gastrointestinal digestion.

Qiao SW, Bergseng E, Molberg Ø, Xia J, Fleckenstein B, Khosla C, Sollid LM.

J Immunol. 2004 Aug 1;173(3):1757-62.

13.

The gluten response in children with celiac disease is directed toward multiple gliadin and glutenin peptides.

Vader W, Kooy Y, Van Veelen P, De Ru A, Harris D, Benckhuijsen W, Peña S, Mearin L, Drijfhout JW, Koning F.

Gastroenterology. 2002 Jun;122(7):1729-37.

PMID:
12055577
14.

Deamidation of gliadin peptides in lamina propria: implications for celiac disease.

Skovbjerg H, Anthonsen D, Knudsen E, Sjöström H.

Dig Dis Sci. 2008 Nov;53(11):2917-24. doi: 10.1007/s10620-008-0450-4. Epub 2008 Aug 5.

PMID:
18679797
15.

HLA-DQ2 and -DQ8 signatures of gluten T cell epitopes in celiac disease.

Tollefsen S, Arentz-Hansen H, Fleckenstein B, Molberg O, Ráki M, Kwok WW, Jung G, Lundin KE, Sollid LM.

J Clin Invest. 2006 Aug;116(8):2226-36. Epub 2006 Jul 27.

16.

Tissue transglutaminase selectively modifies gliadin peptides that are recognized by gut-derived T cells in celiac disease.

Molberg O, Mcadam SN, Körner R, Quarsten H, Kristiansen C, Madsen L, Fugger L, Scott H, Norén O, Roepstorff P, Lundin KE, Sjöström H, Sollid LM.

Nat Med. 1998 Jun;4(6):713-7. Erratum in: Nat Med 1998 Aug;4(8):974.

PMID:
9623982
17.

Deamidation and cross-linking of gliadin peptides by transglutaminases and the relation to celiac disease.

Skovbjerg H, Koch C, Anthonsen D, Sjöström H.

Biochim Biophys Acta. 2004 Nov 5;1690(3):220-30.

18.

Celiac disease: antibody recognition against native and selectively deamidated gliadin peptides.

Aleanzi M, Demonte AM, Esper C, Garcilazo S, Waggener M.

Clin Chem. 2001 Nov;47(11):2023-8.

19.

Transamidation of wheat flour inhibits the response to gliadin of intestinal T cells in celiac disease.

Gianfrani C, Siciliano RA, Facchiano AM, Camarca A, Mazzeo MF, Costantini S, Salvati VM, Maurano F, Mazzarella G, Iaquinto G, Bergamo P, Rossi M.

Gastroenterology. 2007 Sep;133(3):780-9. Epub 2007 Jun 20.

PMID:
17678925
20.

Resistance to celiac disease in humanized HLA-DR3-DQ2-transgenic mice expressing specific anti-gliadin CD4+ T cells.

de Kauwe AL, Chen Z, Anderson RP, Keech CL, Price JD, Wijburg O, Jackson DC, Ladhams J, Allison J, McCluskey J.

J Immunol. 2009 Jun 15;182(12):7440-50. doi: 10.4049/jimmunol.0900233.

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