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Peroxisome proliferator-activated receptor gamma activation restores islet function in diabetic mice through reduction of endoplasmic reticulum stress and maintenance of euchromatin structure.

Evans-Molina C, Robbins RD, Kono T, Tersey SA, Vestermark GL, Nunemaker CS, Garmey JC, Deering TG, Keller SR, Maier B, Mirmira RG.

Mol Cell Biol. 2009 Apr;29(8):2053-67. doi: 10.1128/MCB.01179-08.


PPAR-γ activation restores pancreatic islet SERCA2 levels and prevents β-cell dysfunction under conditions of hyperglycemic and cytokine stress.

Kono T, Ahn G, Moss DR, Gann L, Zarain-Herzberg A, Nishiki Y, Fueger PT, Ogihara T, Evans-Molina C.

Mol Endocrinol. 2012 Feb;26(2):257-71. doi: 10.1210/me.2011-1181.


PPAR-γ activation increases insulin secretion through the up-regulation of the free fatty acid receptor GPR40 in pancreatic β-cells.

Kim HS, Hwang YC, Koo SH, Park KS, Lee MS, Kim KW, Lee MK.

PLoS One. 2013;8(1):e50128. doi: 10.1371/journal.pone.0050128.


Methyltransferase Set7/9 maintains transcription and euchromatin structure at islet-enriched genes.

Deering TG, Ogihara T, Trace AP, Maier B, Mirmira RG.

Diabetes. 2009 Jan;58(1):185-93. doi: 10.2337/db08-1150.


Pancreatic and duodenal homeobox protein 1 (Pdx-1) maintains endoplasmic reticulum calcium levels through transcriptional regulation of sarco-endoplasmic reticulum calcium ATPase 2b (SERCA2b) in the islet β cell.

Johnson JS, Kono T, Tong X, Yamamoto WR, Zarain-Herzberg A, Merrins MJ, Satin LS, Gilon P, Evans-Molina C.

J Biol Chem. 2014 Nov 21;289(47):32798-810. doi: 10.1074/jbc.M114.575191.


Pioglitazone reduces islet triglyceride content and restores impaired glucose-stimulated insulin secretion in heterozygous peroxisome proliferator-activated receptor-gamma-deficient mice on a high-fat diet.

Matsui J, Terauchi Y, Kubota N, Takamoto I, Eto K, Yamashita T, Komeda K, Yamauchi T, Kamon J, Kita S, Noda M, Kadowaki T.

Diabetes. 2004 Nov;53(11):2844-54.


Peroxisome proliferator-activated receptor (PPAR)-alpha agonism prevents the onset of type 2 diabetes in Zucker diabetic fatty rats: A comparison with PPAR gamma agonism.

Bergeron R, Yao J, Woods JW, Zycband EI, Liu C, Li Z, Adams A, Berger JP, Zhang BB, Moller DE, Doebber TW.

Endocrinology. 2006 Sep;147(9):4252-62.


Peroxisome proliferator-activated receptor-gamma regulates expression of PDX-1 and NKX6.1 in INS-1 cells.

Moibi JA, Gupta D, Jetton TL, Peshavaria M, Desai R, Leahy JL.

Diabetes. 2007 Jan;56(1):88-95.


Expression and function of Set7/9 in pancreatic islets.

Ogihara T, Vanderford NL, Maier B, Stein RW, Mirmira RG.

Islets. 2009 Nov-Dec;1(3):269-72. doi: 10.4161/isl.1.3.9779.


Antidiabetic effects of rice hull smoke extract on glucose-regulating mechanism in type 2 diabetic mice.

Yang JY, Moon E, Nam SH, Friedman M.

J Agric Food Chem. 2012 Aug 1;60(30):7442-9. doi: 10.1021/jf3017749.


Persistent expression of HNF6 in islet endocrine cells causes disrupted islet architecture and loss of beta cell function.

Gannon M, Ray MK, Van Zee K, Rausa F, Costa RH, Wright CV.

Development. 2000 Jul;127(13):2883-95.


Transcriptional activity of the islet β cell factor Pdx1 is augmented by lysine methylation catalyzed by the methyltransferase Set7/9.

Maganti AV, Maier B, Tersey SA, Sampley ML, Mosley AL, Özcan S, Pachaiyappan B, Woster PM, Hunter CS, Stein R, Mirmira RG.

J Biol Chem. 2015 Apr 10;290(15):9812-22. doi: 10.1074/jbc.M114.616219.


Age-related impairment in insulin release: the essential role of β(2)-adrenergic receptor.

Santulli G, Lombardi A, Sorriento D, Anastasio A, Del Giudice C, Formisano P, Béguinot F, Trimarco B, Miele C, Iaccarino G.

Diabetes. 2012 Mar;61(3):692-701. doi: 10.2337/db11-1027.


Anti-diabetic effect of mulberry leaf polysaccharide by inhibiting pancreatic islet cell apoptosis and ameliorating insulin secretory capacity in diabetic rats.

Zhang Y, Ren C, Lu G, Mu Z, Cui W, Gao H, Wang Y.

Int Immunopharmacol. 2014 Sep;22(1):248-57. doi: 10.1016/j.intimp.2014.06.039.


Potent anti-diabetic effects of MHY908, a newly synthesized PPAR α/γ dual agonist in db/db mice.

Park MH, Park JY, Lee HJ, Kim DH, Park D, Jeong HO, Park CH, Chun P, Moon HR, Chung HY.

PLoS One. 2013 Nov 14;8(11):e78815. doi: 10.1371/journal.pone.0078815.

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