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The role of RAD6 in recombinational repair, checkpoints and meiosis via histone modification.

Game JC, Chernikova SB.

DNA Repair (Amst). 2009 Apr 5;8(4):470-82. doi: 10.1016/j.dnarep.2009.01.007. Epub 2009 Feb 18. Review.


The DNA damage checkpoint response requires histone H2B ubiquitination by Rad6-Bre1 and H3 methylation by Dot1.

Giannattasio M, Lazzaro F, Plevani P, Muzi-Falconi M.

J Biol Chem. 2005 Mar 18;280(11):9879-86. Epub 2005 Jan 4.


Rad6-Bre1-mediated histone H2B ubiquitylation modulates the formation of double-strand breaks during meiosis.

Yamashita K, Shinohara M, Shinohara A.

Proc Natl Acad Sci U S A. 2004 Aug 3;101(31):11380-5. Epub 2004 Jul 27.


Role of Dot1-dependent histone H3 methylation in G1 and S phase DNA damage checkpoint functions of Rad9.

Wysocki R, Javaheri A, Allard S, Sha F, Côté J, Kron SJ.

Mol Cell Biol. 2005 Oct;25(19):8430-43.


Bre1, an E3 ubiquitin ligase required for recruitment and substrate selection of Rad6 at a promoter.

Wood A, Krogan NJ, Dover J, Schneider J, Heidt J, Boateng MA, Dean K, Golshani A, Zhang Y, Greenblatt JF, Johnston M, Shilatifard A.

Mol Cell. 2003 Jan;11(1):267-74.


The Saccharomyces cerevisiae Rad6 postreplication repair and Siz1/Srs2 homologous recombination-inhibiting pathways process DNA damage that arises in asf1 mutants.

Kats ES, Enserink JM, Martinez S, Kolodner RD.

Mol Cell Biol. 2009 Oct;29(19):5226-37. doi: 10.1128/MCB.00894-09. Epub 2009 Jul 27.


The Paf1 complex is essential for histone monoubiquitination by the Rad6-Bre1 complex, which signals for histone methylation by COMPASS and Dot1p.

Wood A, Schneider J, Dover J, Johnston M, Shilatifard A.

J Biol Chem. 2003 Sep 12;278(37):34739-42. Epub 2003 Jul 21.


The Bur1/Bur2 complex is required for histone H2B monoubiquitination by Rad6/Bre1 and histone methylation by COMPASS.

Wood A, Schneider J, Dover J, Johnston M, Shilatifard A.

Mol Cell. 2005 Nov 23;20(4):589-99.


Monoubiquitination of histone H2B is intrinsic to the Bre1 RING domain-Rad6 interaction and augmented by a second Rad6-binding site on Bre1.

Turco E, Gallego LD, Schneider M, Köhler A.

J Biol Chem. 2015 Feb 27;290(9):5298-310. doi: 10.1074/jbc.M114.626788. Epub 2014 Dec 29.


Rad6-Bre1-mediated H2B ubiquitination regulates telomere replication by promoting telomere-end resection.

Wu Z, Liu J, Zhang QD, Lv DK, Wu NF, Zhou JQ.

Nucleic Acids Res. 2017 Apr 7;45(6):3308-3322. doi: 10.1093/nar/gkx101.


Ubiquitination of histone H2B by Rad6 is required for efficient Dot1-mediated methylation of histone H3 lysine 79.

Ng HH, Xu RM, Zhang Y, Struhl K.

J Biol Chem. 2002 Sep 20;277(38):34655-7. Epub 2002 Aug 6.


DNA damage checkpoints are involved in postreplication repair.

Barbour L, Ball LG, Zhang K, Xiao W.

Genetics. 2006 Dec;174(4):1789-800. Epub 2006 Oct 22.


Ubiquitination of histone H2B regulates H3 methylation and gene silencing in yeast.

Sun ZW, Allis CD.

Nature. 2002 Jul 4;418(6893):104-8. Epub 2002 Jun 23.


Methylation of histone H3 lysine-79 by Dot1p plays multiple roles in the response to UV damage in Saccharomyces cerevisiae.

Bostelman LJ, Keller AM, Albrecht AM, Arat A, Thompson JS.

DNA Repair (Amst). 2007 Mar 1;6(3):383-95. Epub 2007 Jan 30.


RAD6-RAD18-RAD5-pathway-dependent tolerance to chronic low-dose ultraviolet light.

Hishida T, Kubota Y, Carr AM, Iwasaki H.

Nature. 2009 Jan 29;457(7229):612-5. doi: 10.1038/nature07580. Epub 2008 Dec 14.


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