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Items: 1 to 20 of 100

1.

Discovery of novel Myc-Max heterodimer disruptors with a three-dimensional pharmacophore model.

Mustata G, Follis AV, Hammoudeh DI, Metallo SJ, Wang H, Prochownik EV, Lazo JS, Bahar I.

J Med Chem. 2009 Mar 12;52(5):1247-50. doi: 10.1021/jm801278g.

2.

New structural determinants for c-Myc specific heterodimerization with Max and development of a novel homodimeric c-Myc b-HLH-LZ.

Beaulieu ME, McDuff FO, Frappier V, Montagne M, Naud JF, Lavigne P.

J Mol Recognit. 2012 Jul;25(7):414-26. doi: 10.1002/jmr.2203.

PMID:
22733550
3.

In vitro cytotoxicity and in vivo efficacy, pharmacokinetics, and metabolism of 10074-G5, a novel small-molecule inhibitor of c-Myc/Max dimerization.

Clausen DM, Guo J, Parise RA, Beumer JH, Egorin MJ, Lazo JS, Prochownik EV, Eiseman JL.

J Pharmacol Exp Ther. 2010 Dec;335(3):715-27. doi: 10.1124/jpet.110.170555. Epub 2010 Aug 26.

4.

Perturbation of the c-Myc-Max protein-protein interaction via synthetic α-helix mimetics.

Jung KY, Wang H, Teriete P, Yap JL, Chen L, Lanning ME, Hu A, Lambert LJ, Holien T, Sundan A, Cosford ND, Prochownik EV, Fletcher S.

J Med Chem. 2015 Apr 9;58(7):3002-24. doi: 10.1021/jm501440q. Epub 2015 Mar 30.

5.

Small-molecule modulators of c-Myc/Max and Max/Max interactions.

Berg T.

Curr Top Microbiol Immunol. 2011;348:139-49. doi: 10.1007/82_2010_90. Review.

PMID:
20680803
6.

In vivo quantification and perturbation of Myc-Max interactions and the impact on oncogenic potential.

Raffeiner P, Röck R, Schraffl A, Hartl M, Hart JR, Janda KD, Vogt PK, Stefan E, Bister K.

Oncotarget. 2014 Oct 15;5(19):8869-78.

7.

Design and properties of a Myc derivative that efficiently homodimerizes.

Soucek L, Helmer-Citterich M, Sacco A, Jucker R, Cesareni G, Nasi S.

Oncogene. 1998 Nov 12;17(19):2463-72.

8.
9.

Small-molecule inhibitors of c-Myc transcriptional factor suppress proliferation and induce apoptosis of promyelocytic leukemia cell via cell cycle arrest.

Jeong KC, Ahn KO, Yang CH.

Mol Biosyst. 2010 Aug;6(8):1503-9. doi: 10.1039/c002534h. Epub 2010 May 18.

PMID:
20485733
10.

Targeting the c-Myc coiled coil with interfering peptides.

Jouaux EM, Schmidtkunz K, Müller KM, Arndt KM.

J Pept Sci. 2008 Sep;14(9):1022-31. doi: 10.1002/psc.1038.

PMID:
18465834
11.

Low molecular weight inhibitors of Myc-Max interaction and function.

Yin X, Giap C, Lazo JS, Prochownik EV.

Oncogene. 2003 Sep 18;22(40):6151-9.

PMID:
13679853
12.

Unsaturated fatty acids bind Myc-Max transcription factor and inhibit Myc-Max-DNA complex formation.

Chung S, Park S, Yang CH.

Cancer Lett. 2002 Dec 15;188(1-2):153-62.

PMID:
12406560
13.

Structural aspects of interactions within the Myc/Max/Mad network.

Nair SK, Burley SK.

Curr Top Microbiol Immunol. 2006;302:123-43. Review.

PMID:
16620027
14.

The Max homodimeric b-HLH-LZ significantly interferes with the specific heterodimerization between the c-Myc and Max b-HLH-LZ in absence of DNA: a quantitative analysis.

McDuff FO, Naud JF, Montagne M, Sauvé S, Lavigne P.

J Mol Recognit. 2009 Jul-Aug;22(4):261-9. doi: 10.1002/jmr.938.

PMID:
19189276
15.

Structural rationale for the coupled binding and unfolding of the c-Myc oncoprotein by small molecules.

Follis AV, Hammoudeh DI, Wang H, Prochownik EV, Metallo SJ.

Chem Biol. 2008 Nov 24;15(11):1149-55. doi: 10.1016/j.chembiol.2008.09.011.

16.

Mmip1: a novel leucine zipper protein that reverses the suppressive effects of Mad family members on c-myc.

Gupta K, Anand G, Yin X, Grove L, Prochownik EV.

Oncogene. 1998 Mar 5;16(9):1149-59.

17.

Oligopeptides impairing the Myc-Max heterodimerization inhibit lung cancer cell proliferation by reducing Myc transcriptional activity.

D'Agnano I, Valentini A, Gatti G, Chersi A, Felsani A.

J Cell Physiol. 2007 Jan;210(1):72-80.

PMID:
16998799
19.

Stabilizers of the Max homodimer identified in virtual ligand screening inhibit Myc function.

Jiang H, Bower KE, Beuscher AE 4th, Zhou B, Bobkov AA, Olson AJ, Vogt PK.

Mol Pharmacol. 2009 Sep;76(3):491-502. doi: 10.1124/mol.109.054858. Epub 2009 Jun 4.

20.
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