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Lung tumor development in the presence of sphingosine 1-phosphate agonist FTY720.

Salinas NR, Lopes CT, Palma PV, Oshima CT, Bueno V.

Pathol Oncol Res. 2009 Dec;15(4):549-54. doi: 10.1007/s12253-009-9152-2. Epub 2009 Feb 12.


FTY720 and lung tumor development.

Salinas NR, Oshima CT, Cury PM, Cordeiro JA, Bueno V.

Int Immunopharmacol. 2009 Jun;9(6):689-93. doi: 10.1016/j.intimp.2008.12.007. Epub 2009 Jan 13.


FTY720 treatment in experimentally urethane-induced lung tumors.

Lucas da Silva LB, Ribeiro DA, Cury PM, Cordeiro JA, Bueno V.

J Exp Ther Oncol. 2008;7(1):9-15.


Activation of sphingosine 1-phosphate receptor-1 by FTY720 is neuroprotective after ischemic stroke in rats.

Hasegawa Y, Suzuki H, Sozen T, Rolland W, Zhang JH.

Stroke. 2010 Feb;41(2):368-74. doi: 10.1161/STROKEAHA.109.568899. Epub 2009 Nov 25.


Non-phosphorylated FTY720 induces apoptosis of human microglia by activating SREBP2.

Yoshino T, Tabunoki H, Sugiyama S, Ishii K, Kim SU, Satoh J.

Cell Mol Neurobiol. 2011 Oct;31(7):1009-20. doi: 10.1007/s10571-011-9698-x. Epub 2011 Apr 26.


PTEN- and p53-mediated apoptosis and cell cycle arrest by FTY720 in gastric cancer cells and nude mice.

Zheng T, Meng X, Wang J, Chen X, Yin D, Liang Y, Song X, Pan S, Jiang H, Liu L.

J Cell Biochem. 2010 Sep 1;111(1):218-28. doi: 10.1002/jcb.22691.


FTY720 (s)-phosphonate preserves sphingosine 1-phosphate receptor 1 expression and exhibits superior barrier protection to FTY720 in acute lung injury.

Wang L, Sammani S, Moreno-Vinasco L, Letsiou E, Wang T, Camp SM, Bittman R, Garcia JG, Dudek SM.

Crit Care Med. 2014 Mar;42(3):e189-99. doi: 10.1097/CCM.0000000000000097.


Antitumor effects of OSU-2S, a nonimmunosuppressive analogue of FTY720, in hepatocellular carcinoma.

Omar HA, Chou CC, Berman-Booty LD, Ma Y, Hung JH, Wang D, Kogure T, Patel T, Terracciano L, Muthusamy N, Byrd JC, Kulp SK, Chen CS.

Hepatology. 2011 Jun;53(6):1943-58. doi: 10.1002/hep.24293. Epub 2011 May 2.


Sphingosine analog fingolimod (FTY720) increases radiation sensitivity of human breast cancer cells in vitro.

Marvaso G, Barone A, Amodio N, Raimondi L, Agosti V, Altomare E, Scotti V, Lombardi A, Bianco R, Bianco C, Caraglia M, Tassone P, Tagliaferri P.

Cancer Biol Ther. 2014 Jun 1;15(6):797-805. doi: 10.4161/cbt.28556. Epub 2014 Mar 21.


Sphingosine-1-phosphate receptor agonist, FTY720, restores coronary flow reserve in diabetic rats.

Xu H, Jin Y, Ni H, Hu S, Zhang Q.

Circ J. 2014;78(12):2979-86. Epub 2014 Oct 15.


Induction of brain tumor stem cell apoptosis by FTY720: a potential therapeutic agent for glioblastoma.

Estrada-Bernal A, Palanichamy K, Ray Chaudhury A, Van Brocklyn JR.

Neuro Oncol. 2012 Apr;14(4):405-15. doi: 10.1093/neuonc/nos005. Epub 2012 Feb 20.


FTY720 induced Bcl-associated and Fas-independent apoptosis in human renal cancer cells in vitro and significantly reduced in vivo tumor growth in mouse xenograft.

Ubai T, Azuma H, Kotake Y, Inamoto T, Takahara K, Ito Y, Kiyama S, Sakamoto T, Horie S, Muto S, Takahara S, Otsuki Y, Katsuoka Y.

Anticancer Res. 2007 Jan-Feb;27(1A):75-88.


The sphingosine 1-phosphate receptor agonist FTY720 is neuroprotective after cuprizone-induced CNS demyelination.

Slowik A, Schmidt T, Beyer C, Amor S, Clarner T, Kipp M.

Br J Pharmacol. 2015 Jan;172(1):80-92. doi: 10.1111/bph.12938. Epub 2014 Dec 15.


FTY720 (fingolimod) modulates the severity of viral-induced encephalomyelitis and demyelination.

Blanc CA, Rosen H, Lane TE.

J Neuroinflammation. 2014 Aug 20;11:138. doi: 10.1186/s12974-014-0138-y.


FTY720 induces apoptosis in B16F10-NEX2 murine melanoma cells, limits metastatic development in vivo, and modulates the immune system.

Pereira FV, Arruda DC, Figueiredo CR, Massaoka MH, Matsuo AL, Bueno V, Rodrigues EG.

Clinics (Sao Paulo). 2013 Jul;68(7):1018-27. doi: 10.6061/clinics/2013(07)21.


FTY720 (fingolimod) sensitizes prostate cancer cells to radiotherapy by inhibition of sphingosine kinase-1.

Pchejetski D, Bohler T, Brizuela L, Sauer L, Doumerc N, Golzio M, Salunkhe V, TeissiƩ J, Malavaud B, Waxman J, Cuvillier O.

Cancer Res. 2010 Nov 1;70(21):8651-61. doi: 10.1158/0008-5472.CAN-10-1388. Epub 2010 Oct 19.


Prevention, but not cure, of autoimmune diabetes in a NOD.scid transfer model by FTY720 despite effective modulation of blood T cells.

Morris MA, McDuffie M, Nadler JL, Ley K.

Autoimmunity. 2011 Mar;44(2):115-28. doi: 10.3109/08916934.2010.499885. Epub 2010 Aug 9.


The sphingosine-1-phosphate receptor agonist FTY720 prevents the development of anti-glomerular basement membrane glomerulonephritis.

Sui M, Zhou J, Xie R, Liu X, Mu S, Jia X, Ma J, Wu H.

Mol Biol Rep. 2012 Jan;39(1):389-97. doi: 10.1007/s11033-011-0750-1. Epub 2011 Aug 11.


FTY720 ameliorates Th1-mediated colitis in mice by directly affecting the functional activity of CD4+CD25+ regulatory T cells.

Daniel C, Sartory N, Zahn N, Geisslinger G, Radeke HH, Stein JM.

J Immunol. 2007 Feb 15;178(4):2458-68.


FTY720 (fingolimod) in Multiple Sclerosis: therapeutic effects in the immune and the central nervous system.

Brinkmann V.

Br J Pharmacol. 2009 Nov;158(5):1173-82. doi: 10.1111/j.1476-5381.2009.00451.x. Epub 2009 Oct 8. Review.

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