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Pharmacological inhibition of mTORC1 suppresses anatomical, cellular, and behavioral abnormalities in neural-specific Pten knock-out mice.

Zhou J, Blundell J, Ogawa S, Kwon CH, Zhang W, Sinton C, Powell CM, Parada LF.

J Neurosci. 2009 Feb 11;29(6):1773-83. doi: 10.1523/JNEUROSCI.5685-08.2009.


Pten regulates neuronal arborization and social interaction in mice.

Kwon CH, Luikart BW, Powell CM, Zhou J, Matheny SA, Zhang W, Li Y, Baker SJ, Parada LF.

Neuron. 2006 May 4;50(3):377-88.


Development and characterization of NEX- Pten, a novel forebrain excitatory neuron-specific knockout mouse.

Kazdoba TM, Sunnen CN, Crowell B, Lee GH, Anderson AE, D'Arcangelo G.

Dev Neurosci. 2012;34(2-3):198-209. Epub 2012 May 8.


S6k1 is not required for Pten-deficient neuronal hypertrophy.

Chalhoub N, Kozma SC, Baker SJ.

Brain Res. 2006 Jul 19;1100(1):32-41. Epub 2006 Jun 13.


Dysregulation of synaptic plasticity precedes appearance of morphological defects in a Pten conditional knockout mouse model of autism.

Takeuchi K, Gertner MJ, Zhou J, Parada LF, Bennett MV, Zukin RS.

Proc Natl Acad Sci U S A. 2013 Mar 19;110(12):4738-43. doi: 10.1073/pnas.1222803110. Epub 2013 Mar 4.


Early Behavioral Abnormalities and Perinatal Alterations of PTEN/AKT Pathway in Valproic Acid Autism Model Mice.

Yang EJ, Ahn S, Lee K, Mahmood U, Kim HS.

PLoS One. 2016 Apr 12;11(4):e0153298. doi: 10.1371/journal.pone.0153298. eCollection 2016. Erratum in: PLoS One. 2016;11(6):e0157202.


mTor is required for hypertrophy of Pten-deficient neuronal soma in vivo.

Kwon CH, Zhu X, Zhang J, Baker SJ.

Proc Natl Acad Sci U S A. 2003 Oct 28;100(22):12923-8. Epub 2003 Oct 8.


Inhibition of mammalian target of rapamycin with rapamycin reverses hypertrophic cardiomyopathy in mice with cardiomyocyte-specific knockout of PTEN.

Xu X, Roe ND, Weiser-Evans MC, Ren J.

Hypertension. 2014 Apr;63(4):729-39. doi: 10.1161/HYPERTENSIONAHA.113.02526. Epub 2014 Jan 20. Erratum in: Hypertension. 2016 Mar;67(3):e5.


Balancing Proliferation and Connectivity in PTEN-associated Autism Spectrum Disorder.

Tilot AK, Frazier TW 2nd, Eng C.

Neurotherapeutics. 2015 Jul;12(3):609-19. doi: 10.1007/s13311-015-0356-8. Review.


Rapamycin suppresses seizures and neuronal hypertrophy in a mouse model of cortical dysplasia.

Ljungberg MC, Sunnen CN, Lugo JN, Anderson AE, D'Arcangelo G.

Dis Model Mech. 2009 Jul-Aug;2(7-8):389-98. doi: 10.1242/dmm.002386. Epub 2009 May 26.


Deletion of Pten in the mouse enteric nervous system induces ganglioneuromatosis and mimics intestinal pseudoobstruction.

Puig I, Champeval D, De Santa Barbara P, Jaubert F, Lyonnet S, Larue L.

J Clin Invest. 2009 Dec;119(12):3586-96. doi: 10.1172/JCI39929. Epub 2009 Nov 2.


PTEN regulation of local and long-range connections in mouse auditory cortex.

Xiong Q, Oviedo HV, Trotman LC, Zador AM.

J Neurosci. 2012 Feb 1;32(5):1643-52. doi: 10.1523/JNEUROSCI.4480-11.2012.


Mitochondrial dysfunction in Pten haplo-insufficient mice with social deficits and repetitive behavior: interplay between Pten and p53.

Napoli E, Ross-Inta C, Wong S, Hung C, Fujisawa Y, Sakaguchi D, Angelastro J, Omanska-Klusek A, Schoenfeld R, Giulivi C.

PLoS One. 2012;7(8):e42504. doi: 10.1371/journal.pone.0042504. Epub 2012 Aug 10.


Pten regulates neuronal soma size: a mouse model of Lhermitte-Duclos disease.

Kwon CH, Zhu X, Zhang J, Knoop LL, Tharp R, Smeyne RJ, Eberhart CG, Burger PC, Baker SJ.

Nat Genet. 2001 Dec;29(4):404-11.


A seizure-prone phenotype is associated with altered free-running rhythm in Pten mutant mice.

Ogawa S, Kwon CH, Zhou J, Koovakkattu D, Parada LF, Sinton CM.

Brain Res. 2007 Sep 7;1168:112-23. Epub 2007 Jul 20.


Pten Mutations Alter Brain Growth Trajectory and Allocation of Cell Types through Elevated β-Catenin Signaling.

Chen Y, Huang WC, Séjourné J, Clipperton-Allen AE, Page DT.

J Neurosci. 2015 Jul 15;35(28):10252-67. doi: 10.1523/JNEUROSCI.5272-14.2015.


Hyperactivity of newborn Pten knock-out neurons results from increased excitatory synaptic drive.

Williams MR, DeSpenza T Jr, Li M, Gulledge AT, Luikart BW.

J Neurosci. 2015 Jan 21;35(3):943-59. doi: 10.1523/JNEUROSCI.3144-14.2015.


PTEN deletion enhances survival, neurite outgrowth and function of dopamine neuron grafts to MitoPark mice.

Zhang Y, Granholm AC, Huh K, Shan L, Diaz-Ruiz O, Malik N, Olson L, Hoffer BJ, Lupica CR, Hoffman AF, Bäckman CM.

Brain. 2012 Sep;135(Pt 9):2736-49. doi: 10.1093/brain/aws196.


Rapamycin prevents, but does not reverse, aberrant migration in Pten knockout neurons.

Getz SA, DeSpenza T Jr, Li M, Luikart BW.

Neurobiol Dis. 2016 Sep;93:12-20. doi: 10.1016/j.nbd.2016.03.010. Epub 2016 Mar 15.

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