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Items: 1 to 20 of 96

1.

In vitro complementation of Tdp1 deficiency indicates a stabilized enzyme-DNA adduct from tyrosyl but not glycolate lesions as a consequence of the SCAN1 mutation.

Hawkins AJ, Subler MA, Akopiants K, Wiley JL, Taylor SM, Rice AC, Windle JJ, Valerie K, Povirk LF.

DNA Repair (Amst). 2009 May 1;8(5):654-63. doi: 10.1016/j.dnarep.2008.12.012. Epub 2009 Feb 10.

2.

Deficiency in 3'-phosphoglycolate processing in human cells with a hereditary mutation in tyrosyl-DNA phosphodiesterase (TDP1).

Zhou T, Lee JW, Tatavarthi H, Lupski JR, Valerie K, Povirk LF.

Nucleic Acids Res. 2005 Jan 12;33(1):289-97. Print 2005.

3.

Tyrosyl-DNA phosphodiesterase and the repair of 3'-phosphoglycolate-terminated DNA double-strand breaks.

Zhou T, Akopiants K, Mohapatra S, Lin PS, Valerie K, Ramsden DA, Lees-Miller SP, Povirk LF.

DNA Repair (Amst). 2009 Aug 6;8(8):901-11. doi: 10.1016/j.dnarep.2009.05.003. Epub 2009 Jun 7.

4.

Spinocerebellar ataxia with axonal neuropathy: consequence of a Tdp1 recessive neomorphic mutation?

Hirano R, Interthal H, Huang C, Nakamura T, Deguchi K, Choi K, Bhattacharjee MB, Arimura K, Umehara F, Izumo S, Northrop JL, Salih MA, Inoue K, Armstrong DL, Champoux JJ, Takashima H, Boerkoel CF.

EMBO J. 2007 Nov 14;26(22):4732-43. Epub 2007 Oct 18.

5.

Tyrosyl-DNA phosphodiesterase I catalytic mutants reveal an alternative nucleophile that can catalyze substrate cleavage.

Comeaux EQ, Cuya SM, Kojima K, Jafari N, Wanzeck KC, Mobley JA, Bjornsti MA, van Waardenburg RC.

J Biol Chem. 2015 Mar 6;290(10):6203-14. doi: 10.1074/jbc.M114.635284. Epub 2015 Jan 21.

6.

Hereditary ataxia SCAN1 cells are defective for the repair of transcription-dependent topoisomerase I cleavage complexes.

Miao ZH, Agama K, Sordet O, Povirk L, Kohn KW, Pommier Y.

DNA Repair (Amst). 2006 Dec 9;5(12):1489-94. Epub 2006 Aug 28.

PMID:
16935573
7.

DNA single-strand break repair and spinocerebellar ataxia with axonal neuropathy-1.

el-Khamisy SF, Caldecott KW.

Neuroscience. 2007 Apr 14;145(4):1260-6. Epub 2006 Oct 11. Review.

PMID:
17045754
8.

Defective DNA single-strand break repair in spinocerebellar ataxia with axonal neuropathy-1.

El-Khamisy SF, Saifi GM, Weinfeld M, Johansson F, Helleday T, Lupski JR, Caldecott KW.

Nature. 2005 Mar 3;434(7029):108-13.

PMID:
15744309
9.

Spinocerebellar ataxia with axonal neuropathy.

Walton C, Interthal H, Hirano R, Salih MA, Takashima H, Boerkoel CF.

Adv Exp Med Biol. 2010;685:75-83. Review.

PMID:
20687496
10.

Human Tdp1 cleaves a broad spectrum of substrates, including phosphoamide linkages.

Interthal H, Chen HJ, Champoux JJ.

J Biol Chem. 2005 Oct 28;280(43):36518-28. Epub 2005 Aug 31.

11.

Synergistic decrease of DNA single-strand break repair rates in mouse neural cells lacking both Tdp1 and aprataxin.

El-Khamisy SF, Katyal S, Patel P, Ju L, McKinnon PJ, Caldecott KW.

DNA Repair (Amst). 2009 Jun 4;8(6):760-6. doi: 10.1016/j.dnarep.2009.02.002. Epub 2009 Mar 19.

12.

Conversion of phosphoglycolate to phosphate termini on 3' overhangs of DNA double strand breaks by the human tyrosyl-DNA phosphodiesterase hTdp1.

Inamdar KV, Pouliot JJ, Zhou T, Lees-Miller SP, Rasouli-Nia A, Povirk LF.

J Biol Chem. 2002 Jul 26;277(30):27162-8. Epub 2002 May 21.

13.

Tyrosyl-DNA phosphodiesterase (Tdp1) (3'-phosphotyrosyl DNA phosphodiesterase).

Raymond AC, Burgin AB Jr.

Methods Enzymol. 2006;409:511-24.

PMID:
16793421
14.

Mutation of TDP1, encoding a topoisomerase I-dependent DNA damage repair enzyme, in spinocerebellar ataxia with axonal neuropathy.

Takashima H, Boerkoel CF, John J, Saifi GM, Salih MA, Armstrong D, Mao Y, Quiocho FA, Roa BB, Nakagawa M, Stockton DW, Lupski JR.

Nat Genet. 2002 Oct;32(2):267-72. Epub 2002 Sep 16.

PMID:
12244316
15.

TDP1-dependent DNA single-strand break repair and neurodegeneration.

El-Khamisy SF, Caldecott KW.

Mutagenesis. 2006 Jul;21(4):219-24. Epub 2006 Jun 14. Review.

PMID:
16775218
16.

Tracking the processing of damaged DNA double-strand break ends by ligation-mediated PCR: increased persistence of 3'-phosphoglycolate termini in SCAN1 cells.

Akopiants K, Mohapatra S, Menon V, Zhou T, Valerie K, Povirk LF.

Nucleic Acids Res. 2014 Mar;42(5):3125-37. doi: 10.1093/nar/gkt1347. Epub 2013 Dec 25.

17.

SCAN1 mutant Tdp1 accumulates the enzyme--DNA intermediate and causes camptothecin hypersensitivity.

Interthal H, Chen HJ, Kehl-Fie TE, Zotzmann J, Leppard JB, Champoux JJ.

EMBO J. 2005 Jun 15;24(12):2224-33. Epub 2005 May 26.

18.

TDP1 facilitates repair of ionizing radiation-induced DNA single-strand breaks.

El-Khamisy SF, Hartsuiker E, Caldecott KW.

DNA Repair (Amst). 2007 Oct 1;6(10):1485-95. Epub 2007 Jun 28.

PMID:
17600775
19.

Tyrosyl-DNA phosphodiesterase I resolves both naturally and chemically induced DNA adducts and its potential as a therapeutic target.

Comeaux EQ, van Waardenburg RC.

Drug Metab Rev. 2014 Nov;46(4):494-507. doi: 10.3109/03602532.2014.971957. Epub 2014 Oct 20. Review.

PMID:
25327705
20.

TDP1 facilitates chromosomal single-strand break repair in neurons and is neuroprotective in vivo.

Katyal S, el-Khamisy SF, Russell HR, Li Y, Ju L, Caldecott KW, McKinnon PJ.

EMBO J. 2007 Nov 14;26(22):4720-31. Epub 2007 Oct 4.

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