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Items: 1 to 20 of 89

1.

Small molecule blockers of the Alzheimer Abeta calcium channel potently protect neurons from Abeta cytotoxicity.

Diaz JC, Simakova O, Jacobson KA, Arispe N, Pollard HB.

Proc Natl Acad Sci U S A. 2009 Mar 3;106(9):3348-53. doi: 10.1073/pnas.0813355106.

2.

Effects of amyloid-β peptides on voltage-gated L-type Ca(V)1.2 and Ca(V)1.3 Ca(2+) channels.

Kim S, Rhim H.

Mol Cells. 2011 Sep;32(3):289-94. doi: 10.1007/s10059-011-0075-x.

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Targeting the neurotoxic species in Alzheimer's disease: inhibitors of Abeta oligomerization.

De Felice FG, Vieira MN, Saraiva LM, Figueroa-Villar JD, Garcia-Abreu J, Liu R, Chang L, Klein WL, Ferreira ST.

FASEB J. 2004 Sep;18(12):1366-72.

PMID:
15333579
6.

Targeting group II metabotropic glutamate (mGlu) receptors for the treatment of psychosis associated with Alzheimer's disease: selective activation of mGlu2 receptors amplifies beta-amyloid toxicity in cultured neurons, whereas dual activation of mGlu2 and mGlu3 receptors is neuroprotective.

Caraci F, Molinaro G, Battaglia G, Giuffrida ML, Riozzi B, Traficante A, Bruno V, Cannella M, Merlo S, Wang X, Heinz BA, Nisenbaum ES, Britton TC, Drago F, Sortino MA, Copani A, Nicoletti F.

Mol Pharmacol. 2011 Mar;79(3):618-26. doi: 10.1124/mol.110.067488.

7.

Truncated beta-amyloid peptide channels provide an alternative mechanism for Alzheimer's Disease and Down syndrome.

Jang H, Arce FT, Ramachandran S, Capone R, Azimova R, Kagan BL, Nussinov R, Lal R.

Proc Natl Acad Sci U S A. 2010 Apr 6;107(14):6538-43. doi: 10.1073/pnas.0914251107.

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9.

Bexarotene blocks calcium-permeable ion channels formed by neurotoxic Alzheimer's β-amyloid peptides.

Fantini J, Di Scala C, Yahi N, Troadec JD, Sadelli K, Chahinian H, Garmy N.

ACS Chem Neurosci. 2014 Mar 19;5(3):216-24. doi: 10.1021/cn400183w.

10.

Synthetic Aβ oligomers (Aβ(1-42) globulomer) modulate presynaptic calcium currents: prevention of Aβ-induced synaptic deficits by calcium channel blockers.

Hermann D, Mezler M, Müller MK, Wicke K, Gross G, Draguhn A, Bruehl C, Nimmrich V.

Eur J Pharmacol. 2013 Feb 28;702(1-3):44-55. doi: 10.1016/j.ejphar.2013.01.030.

PMID:
23376566
11.

Triptolide attenuated injury via inhibiting oxidative stress in Amyloid-Beta25-35-treated differentiated PC12 cells.

Xu P, Wang H, Li Z, Yang Z.

Life Sci. 2016 Jan 15;145:19-26. doi: 10.1016/j.lfs.2015.12.018.

PMID:
26679104
12.

Suppression of a neocortical potassium channel activity by intracellular amyloid-β and its rescue with Homer1a.

Yamamoto K, Ueta Y, Wang L, Yamamoto R, Inoue N, Inokuchi K, Aiba A, Yonekura H, Kato N.

J Neurosci. 2011 Aug 3;31(31):11100-9. doi: 10.1523/JNEUROSCI.6752-10.2011.

13.

Calcium channel blockers and dementia.

Nimmrich V, Eckert A.

Br J Pharmacol. 2013 Jul;169(6):1203-10. doi: 10.1111/bph.12240. Review.

14.

Protective effect of centipedegrass against Aβ oligomerization and Aβ-mediated cell death in PC12 cells.

Song Y, Kim HD, Lee MK, Kim MK, Kang SN, Ko YG, Won CK, Kim GS, Lee SS, Bai HW, Chung BY, Cho JH.

Pharm Biol. 2015;53(9):1260-6. doi: 10.3109/13880209.2014.974062.

PMID:
25853960
15.

Induction of methionine-sulfoxide reductases protects neurons from amyloid β-protein insults in vitro and in vivo.

Moskovitz J, Maiti P, Lopes DH, Oien DB, Attar A, Liu T, Mittal S, Hayes J, Bitan G.

Biochemistry. 2011 Dec 13;50(49):10687-97. doi: 10.1021/bi201426b.

16.

Inhibition of Alzheimer's amyloid toxicity with a tricyclic pyrone molecule in vitro and in vivo.

Hong HS, Rana S, Barrigan L, Shi A, Zhang Y, Zhou F, Jin LW, Hua DH.

J Neurochem. 2009 Feb;108(4):1097-1108. doi: 10.1111/j.1471-4159.2008.05866.x.

17.

Effects of a tacrine-8-hydroxyquinoline hybrid (IQM-622) on Aβ accumulation and cell death: involvement in hippocampal neuronal loss in Alzheimer's disease.

Antequera D, Bolos M, Spuch C, Pascual C, Ferrer I, Fernandez-Bachiller MI, Rodríguez-Franco MI, Carro E.

Neurobiol Dis. 2012 Jun;46(3):682-91. doi: 10.1016/j.nbd.2012.03.009.

PMID:
22426395
18.

Interaction of Alzheimer's β-amyloid peptides with cholesterol: mechanistic insights into amyloid pore formation.

Di Scala C, Chahinian H, Yahi N, Garmy N, Fantini J.

Biochemistry. 2014 Jul 22;53(28):4489-502. doi: 10.1021/bi500373k. Review.

PMID:
25000142
19.

Amyloid peptide-mediated hypoxic regulation of Ca2+ channels in PC12 cells.

Peers C, Green KN, Boyle JP.

Adv Exp Med Biol. 2003;536:187-92. No abstract available.

PMID:
14635666
20.

Amyloid beta ion channel: 3D structure and relevance to amyloid channel paradigm.

Lal R, Lin H, Quist AP.

Biochim Biophys Acta. 2007 Aug;1768(8):1966-75. Review.

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