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Items: 1 to 20 of 85

1.

The RIDDLE syndrome protein mediates a ubiquitin-dependent signaling cascade at sites of DNA damage.

Stewart GS, Panier S, Townsend K, Al-Hakim AK, Kolas NK, Miller ES, Nakada S, Ylanko J, Olivarius S, Mendez M, Oldreive C, Wildenhain J, Tagliaferro A, Pelletier L, Taubenheim N, Durandy A, Byrd PJ, Stankovic T, Taylor AM, Durocher D.

Cell. 2009 Feb 6;136(3):420-34. doi: 10.1016/j.cell.2008.12.042.

2.

Histone H1 couples initiation and amplification of ubiquitin signalling after DNA damage.

Thorslund T, Ripplinger A, Hoffmann S, Wild T, Uckelmann M, Villumsen B, Narita T, Sixma TK, Choudhary C, Bekker-Jensen S, Mailand N.

Nature. 2015 Nov 19;527(7578):389-93. doi: 10.1038/nature15401.

PMID:
26503038
3.

Genomic instability, defective spermatogenesis, immunodeficiency, and cancer in a mouse model of the RIDDLE syndrome.

Bohgaki T, Bohgaki M, Cardoso R, Panier S, Zeegers D, Li L, Stewart GS, Sanchez O, Hande MP, Durocher D, Hakem A, Hakem R.

PLoS Genet. 2011 Apr;7(4):e1001381. doi: 10.1371/journal.pgen.1001381.

4.

Solving the RIDDLE of 53BP1 recruitment to sites of damage.

Stewart GS.

Cell Cycle. 2009 May 15;8(10):1532-8. Review.

PMID:
19372751
5.

Homozygous deficiency of ubiquitin-ligase ring-finger protein RNF168 mimics the radiosensitivity syndrome of ataxia-telangiectasia.

Devgan SS, Sanal O, Doil C, Nakamura K, Nahas SA, Pettijohn K, Bartek J, Lukas C, Lukas J, Gatti RA.

Cell Death Differ. 2011 Sep;18(9):1500-6. doi: 10.1038/cdd.2011.18.

6.

RNF8 E3 Ubiquitin Ligase Stimulates Ubc13 E2 Conjugating Activity That Is Essential for DNA Double Strand Break Signaling and BRCA1 Tumor Suppressor Recruitment.

Hodge CD, Ismail IH, Edwards RA, Hura GL, Xiao AT, Tainer JA, Hendzel MJ, Glover JN.

J Biol Chem. 2016 Apr 29;291(18):9396-410. doi: 10.1074/jbc.M116.715698.

PMID:
26903517
7.

RNF168 binds and amplifies ubiquitin conjugates on damaged chromosomes to allow accumulation of repair proteins.

Doil C, Mailand N, Bekker-Jensen S, Menard P, Larsen DH, Pepperkok R, Ellenberg J, Panier S, Durocher D, Bartek J, Lukas J, Lukas C.

Cell. 2009 Feb 6;136(3):435-46. doi: 10.1016/j.cell.2008.12.041.

8.

Ubiquitin-H2AX fusions render 53BP1 recruitment to DNA damage sites independent of RNF8 or RNF168.

Kocyłowski MK, Rey AJ, Stewart GS, Halazonetis TD.

Cell Cycle. 2015;14(11):1748-58. doi: 10.1080/15384101.2015.1010918.

9.

USP3 counteracts RNF168 via deubiquitinating H2A and γH2AX at lysine 13 and 15.

Sharma N, Zhu Q, Wani G, He J, Wang QE, Wani AA.

Cell Cycle. 2014;13(1):106-14. doi: 10.4161/cc.26814.

10.

The deubiquitylating enzyme USP44 counteracts the DNA double-strand break response mediated by the RNF8 and RNF168 ubiquitin ligases.

Mosbech A, Lukas C, Bekker-Jensen S, Mailand N.

J Biol Chem. 2013 Jun 7;288(23):16579-87. doi: 10.1074/jbc.M113.459917.

11.

Poly(ADP-ribosyl)ation links the chromatin remodeler SMARCA5/SNF2H to RNF168-dependent DNA damage signaling.

Smeenk G, Wiegant WW, Marteijn JA, Luijsterburg MS, Sroczynski N, Costelloe T, Romeijn RJ, Pastink A, Mailand N, Vermeulen W, van Attikum H.

J Cell Sci. 2013 Feb 15;126(Pt 4):889-903. doi: 10.1242/jcs.109413.

12.

Orchestration of the DNA-damage response by the RNF8 ubiquitin ligase.

Kolas NK, Chapman JR, Nakada S, Ylanko J, Chahwan R, Sweeney FD, Panier S, Mendez M, Wildenhain J, Thomson TM, Pelletier L, Jackson SP, Durocher D.

Science. 2007 Dec 7;318(5856):1637-40.

13.

RNF168 ubiquitylates 53BP1 and controls its response to DNA double-strand breaks.

Bohgaki M, Bohgaki T, El Ghamrasni S, Srikumar T, Maire G, Panier S, Fradet-Turcotte A, Stewart GS, Raught B, Hakem A, Hakem R.

Proc Natl Acad Sci U S A. 2013 Dec 24;110(52):20982-7. doi: 10.1073/pnas.1320302111.

14.

USP7 deubiquitinase promotes ubiquitin-dependent DNA damage signaling by stabilizing RNF168.

Zhu Q, Sharma N, He J, Wani G, Wani AA.

Cell Cycle. 2015;14(9):1413-25. doi: 10.1080/15384101.2015.1007785.

15.

RNF168 promotes noncanonical K27 ubiquitination to signal DNA damage.

Gatti M, Pinato S, Maiolica A, Rocchio F, Prato MG, Aebersold R, Penengo L.

Cell Rep. 2015 Jan 13;10(2):226-38. doi: 10.1016/j.celrep.2014.12.021.

16.

RNF168 ubiquitinates K13-15 on H2A/H2AX to drive DNA damage signaling.

Mattiroli F, Vissers JH, van Dijk WJ, Ikpa P, Citterio E, Vermeulen W, Marteijn JA, Sixma TK.

Cell. 2012 Sep 14;150(6):1182-95. doi: 10.1016/j.cell.2012.08.005.

17.

Mammalian SUMO E3-ligases PIAS1 and PIAS4 promote responses to DNA double-strand breaks.

Galanty Y, Belotserkovskaya R, Coates J, Polo S, Miller KM, Jackson SP.

Nature. 2009 Dec 17;462(7275):935-9. doi: 10.1038/nature08657.

18.

Molecular insights into the function of RING finger (RNF)-containing proteins hRNF8 and hRNF168 in Ubc13/Mms2-dependent ubiquitylation.

Campbell SJ, Edwards RA, Leung CC, Neculai D, Hodge CD, Dhe-Paganon S, Glover JN.

J Biol Chem. 2012 Jul 6;287(28):23900-10. doi: 10.1074/jbc.M112.359653.

19.

The ubiquitin- and SUMO-dependent signaling response to DNA double-strand breaks.

Bekker-Jensen S, Mailand N.

FEBS Lett. 2011 Sep 16;585(18):2914-9. doi: 10.1016/j.febslet.2011.05.056. Review.

20.

Ring finger protein RNF169 antagonizes the ubiquitin-dependent signaling cascade at sites of DNA damage.

Chen J, Feng W, Jiang J, Deng Y, Huen MS.

J Biol Chem. 2012 Aug 10;287(33):27715-22. doi: 10.1074/jbc.M112.373530.

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