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Androgen-androgen receptor system protects against angiotensin II-induced vascular remodeling.

Ikeda Y, Aihara K, Yoshida S, Sato T, Yagi S, Iwase T, Sumitomo Y, Ise T, Ishikawa K, Azuma H, Akaike M, Kato S, Matsumoto T.

Endocrinology. 2009 Jun;150(6):2857-64. doi: 10.1210/en.2008-1254. Epub 2009 Feb 5.


Androgen receptor gene knockout male mice exhibit impaired cardiac growth and exacerbation of angiotensin II-induced cardiac fibrosis.

Ikeda Y, Aihara K, Sato T, Akaike M, Yoshizumi M, Suzaki Y, Izawa Y, Fujimura M, Hashizume S, Kato M, Yagi S, Tamaki T, Kawano H, Matsumoto T, Azuma H, Kato S, Matsumoto T.

J Biol Chem. 2005 Aug 19;280(33):29661-6. Epub 2005 Jun 16.


Androgen receptor counteracts Doxorubicin-induced cardiotoxicity in male mice.

Ikeda Y, Aihara K, Akaike M, Sato T, Ishikawa K, Ise T, Yagi S, Iwase T, Ueda Y, Yoshida S, Azuma H, Walsh K, Tamaki T, Kato S, Matsumoto T.

Mol Endocrinol. 2010 Jul;24(7):1338-48. doi: 10.1210/me.2009-0402. Epub 2010 May 25.


Pitavastatin, an HMG-CoA reductase inhibitor, exerts eNOS-independent protective actions against angiotensin II induced cardiovascular remodeling and renal insufficiency.

Yagi S, Aihara K, Ikeda Y, Sumitomo Y, Yoshida S, Ise T, Iwase T, Ishikawa K, Azuma H, Akaike M, Matsumoto T.

Circ Res. 2008 Jan 4;102(1):68-76. Epub 2007 Oct 25.


Endothelial nitric oxide synthase-independent protective action of statin against angiotensin II-induced atrial remodeling via reduced oxidant injury.

Yagi S, Akaike M, Aihara K, Ishikawa K, Iwase T, Ikeda Y, Soeki T, Yoshida S, Sumitomo-Ueda Y, Matsumoto T, Sata M.

Hypertension. 2010 Apr;55(4):918-23. doi: 10.1161/HYPERTENSIONAHA.109.146076. Epub 2010 Mar 1.


Angiotensin II impairs endothelial progenitor cell number and function in vitro and in vivo: implications for vascular regeneration.

Endtmann C, Ebrahimian T, Czech T, Arfa O, Laufs U, Fritz M, Wassmann K, Werner N, Petoumenos V, Nickenig G, Wassmann S.

Hypertension. 2011 Sep;58(3):394-403. doi: 10.1161/HYPERTENSIONAHA.110.169193. Epub 2011 Aug 8.


Apoptosis signal-regulating kinase 1 plays a pivotal role in angiotensin II-induced cardiac hypertrophy and remodeling.

Izumiya Y, Kim S, Izumi Y, Yoshida K, Yoshiyama M, Matsuzawa A, Ichijo H, Iwao H.

Circ Res. 2003 Oct 31;93(9):874-83. Epub 2003 Oct 9. Erratum in: Circ Res. 2016 Mar 4;118(5):e32.


Angiotensin-(1-7) counteracts angiotensin II-induced dysfunction in cerebral endothelial cells via modulating Nox2/ROS and PI3K/NO pathways.

Xiao X, Zhang C, Ma X, Miao H, Wang J, Liu L, Chen S, Zeng R, Chen Y, Bihl JC.

Exp Cell Res. 2015 Aug 1;336(1):58-65. doi: 10.1016/j.yexcr.2015.06.010. Epub 2015 Jun 19.


Propofol attenuates angiotensin II-induced apoptosis in human coronary artery endothelial cells.

Chen J, Chen W, Zhu M, Zhu Y, Yin H, Tan Z.

Br J Anaesth. 2011 Oct;107(4):525-32. doi: 10.1093/bja/aer197. Epub 2011 Jul 4.


TGF-beta inhibits Ang II-induced MAPK p44/42 signaling in vascular smooth muscle cells by Ang II type 1 receptor downregulation.

Meijering BD, van der Wouden EA, Pelgröm V, Henning RH, Sharma K, Deelman LE.

J Vasc Res. 2009;46(5):459-68. doi: 10.1159/000200961. Epub 2009 Feb 10.


Local angiotensin II aggravates cardiac remodeling in hypertension.

Xu J, Carretero OA, Liao TD, Peng H, Shesely EG, Xu J, Liu TS, Yang JJ, Reudelhuber TL, Yang XP.

Am J Physiol Heart Circ Physiol. 2010 Nov;299(5):H1328-38. doi: 10.1152/ajpheart.00538.2010. Epub 2010 Sep 10.


Role of oxidative stress in angiotensin II-induced enhanced expression of Gi(alpha) proteins and adenylyl cyclase signaling in A10 vascular smooth muscle cells.

Li Y, Lappas G, Anand-Srivastava MB.

Am J Physiol Heart Circ Physiol. 2007 Apr;292(4):H1922-30. Epub 2006 Dec 8.


Vasoprotective and atheroprotective effects of angiotensin (1-7) in apolipoprotein E-deficient mice.

Tesanovic S, Vinh A, Gaspari TA, Casley D, Widdop RE.

Arterioscler Thromb Vasc Biol. 2010 Aug;30(8):1606-13. doi: 10.1161/ATVBAHA.110.204453. Epub 2010 May 6.


Cardiac angiotensin II type 2 receptor activates the kinin/NO system and inhibits fibrosis.

Kurisu S, Ozono R, Oshima T, Kambe M, Ishida T, Sugino H, Matsuura H, Chayama K, Teranishi Y, Iba O, Amano K, Matsubara H.

Hypertension. 2003 Jan;41(1):99-107.


Impaired flow-induced dilation of coronary arterioles of dogs fed a low-salt diet: roles of ANG II, PKC, and NAD(P)H oxidase.

Huang A, Yan C, Suematsu N, Cuevas A, Yang YM, Kertowidjojo E, Hintze TH, Kaley G, Sun D.

Am J Physiol Heart Circ Physiol. 2010 Nov;299(5):H1476-83. doi: 10.1152/ajpheart.01250.2009. Epub 2010 Sep 10.


Differential vasoconstrictions induced by angiotensin II: role of AT1 and AT2 receptors in isolated C57BL/6J mouse blood vessels.

Zhou Y, Dirksen WP, Babu GJ, Periasamy M.

Am J Physiol Heart Circ Physiol. 2003 Dec;285(6):H2797-803. Epub 2003 Aug 7.

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