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Items: 1 to 20 of 159

1.

Expression of the leukemia oncogene Lmo2 is controlled by an array of tissue-specific elements dispersed over 100 kb and bound by Tal1/Lmo2, Ets, and Gata factors.

Landry JR, Bonadies N, Kinston S, Knezevic K, Wilson NK, Oram SH, Janes M, Piltz S, Hammett M, Carter J, Hamilton T, Donaldson IJ, Lacaud G, Frampton J, Follows G, Kouskoff V, Göttgens B.

Blood. 2009 Jun 4;113(23):5783-92. doi: 10.1182/blood-2008-11-187757. Epub 2009 Jan 26.

2.

A DNA-binding mutant of TAL1 cooperates with LMO2 to cause T cell leukemia in mice.

Draheim KM, Hermance N, Yang Y, Arous E, Calvo J, Kelliher MA.

Oncogene. 2011 Mar 10;30(10):1252-60. doi: 10.1038/onc.2010.495. Epub 2010 Nov 8.

3.

Fli1, Elf1, and Ets1 regulate the proximal promoter of the LMO2 gene in endothelial cells.

Landry JR, Kinston S, Knezevic K, Donaldson IJ, Green AR, Göttgens B.

Blood. 2005 Oct 15;106(8):2680-7. Epub 2005 Jun 30.

4.

A previously unrecognized promoter of LMO2 forms part of a transcriptional regulatory circuit mediating LMO2 expression in a subset of T-acute lymphoblastic leukaemia patients.

Oram SH, Thoms JA, Pridans C, Janes ME, Kinston SJ, Anand S, Landry JR, Lock RB, Jayaraman PS, Huntly BJ, Pimanda JE, Göttgens B.

Oncogene. 2010 Oct 28;29(43):5796-808. doi: 10.1038/onc.2010.320. Epub 2010 Aug 2.

PMID:
20676125
5.

Structure of the leukemia oncogene LMO2: implications for the assembly of a hematopoietic transcription factor complex.

El Omari K, Hoosdally SJ, Tuladhar K, Karia D, Vyas P, Patient R, Porcher C, Mancini EJ.

Blood. 2011 Feb 17;117(7):2146-56. doi: 10.1182/blood-2010-07-293357. Epub 2010 Nov 12.

6.

Runx genes are direct targets of Scl/Tal1 in the yolk sac and fetal liver.

Landry JR, Kinston S, Knezevic K, de Bruijn MF, Wilson N, Nottingham WT, Peitz M, Edenhofer F, Pimanda JE, Ottersbach K, Göttgens B.

Blood. 2008 Mar 15;111(6):3005-14. doi: 10.1182/blood-2007-07-098830. Epub 2008 Jan 9.

7.

The transcription factors Scl and Lmo2 act together during development of the hemangioblast in zebrafish.

Patterson LJ, Gering M, Eckfeldt CE, Green AR, Verfaillie CM, Ekker SC, Patient R.

Blood. 2007 Mar 15;109(6):2389-98. Epub 2006 Nov 7.

8.

The Hematopoietic Stem and Progenitor Cell Cistrome: GATA Factor-Dependent cis-Regulatory Mechanisms.

Hewitt KJ, Johnson KD, Gao X, Keles S, Bresnick EH.

Curr Top Dev Biol. 2016;118:45-76. doi: 10.1016/bs.ctdb.2016.01.002. Epub 2016 Feb 26. Review.

PMID:
27137654
9.

Angiopoietin-2 is a direct transcriptional target of TAL1, LYL1 and LMO2 in endothelial cells.

Deleuze V, El-Hajj R, Chalhoub E, Dohet C, Pinet V, Couttet P, Mathieu D.

PLoS One. 2012;7(7):e40484. doi: 10.1371/journal.pone.0040484. Epub 2012 Jul 6.

10.

SCL and associated proteins distinguish active from repressive GATA transcription factor complexes.

Tripic T, Deng W, Cheng Y, Zhang Y, Vakoc CR, Gregory GD, Hardison RC, Blobel GA.

Blood. 2009 Mar 5;113(10):2191-201. doi: 10.1182/blood-2008-07-169417. Epub 2008 Nov 14.

11.

ERG promotes T-acute lymphoblastic leukemia and is transcriptionally regulated in leukemic cells by a stem cell enhancer.

Thoms JA, Birger Y, Foster S, Knezevic K, Kirschenbaum Y, Chandrakanthan V, Jonquieres G, Spensberger D, Wong JW, Oram SH, Kinston SJ, Groner Y, Lock R, MacKenzie KL, Göttgens B, Izraeli S, Pimanda JE.

Blood. 2011 Jun 30;117(26):7079-89. doi: 10.1182/blood-2010-12-317990. Epub 2011 May 2.

12.

Runx1-mediated hematopoietic stem-cell emergence is controlled by a Gata/Ets/SCL-regulated enhancer.

Nottingham WT, Jarratt A, Burgess M, Speck CL, Cheng JF, Prabhakar S, Rubin EM, Li PS, Sloane-Stanley J, Kong-A-San J, de Bruijn MF.

Blood. 2007 Dec 15;110(13):4188-97. Epub 2007 Sep 6.

13.

Building multifunctionality into a complex containing master regulators of hematopoiesis.

Fujiwara T, Lee HY, Sanalkumar R, Bresnick EH.

Proc Natl Acad Sci U S A. 2010 Nov 23;107(47):20429-34. doi: 10.1073/pnas.1007804107. Epub 2010 Nov 8.

14.
15.

LMO2 is required for TAL1 DNA binding activity and initiation of definitive haematopoiesis at the haemangioblast stage.

Stanulovic VS, Cauchy P, Assi SA, Hoogenkamp M.

Nucleic Acids Res. 2017 Sep 29;45(17):9874-9888. doi: 10.1093/nar/gkx573.

16.

The paralogous hematopoietic regulators Lyl1 and Scl are coregulated by Ets and GATA factors, but Lyl1 cannot rescue the early Scl-/- phenotype.

Chan WY, Follows GA, Lacaud G, Pimanda JE, Landry JR, Kinston S, Knezevic K, Piltz S, Donaldson IJ, Gambardella L, Sablitzky F, Green AR, Kouskoff V, Göttgens B.

Blood. 2007 Mar 1;109(5):1908-16. Epub 2006 Oct 19.

17.

Notch1 inhibition targets the leukemia-initiating cells in a Tal1/Lmo2 mouse model of T-ALL.

Tatarek J, Cullion K, Ashworth T, Gerstein R, Aster JC, Kelliher MA.

Blood. 2011 Aug 11;118(6):1579-90. doi: 10.1182/blood-2010-08-300343. Epub 2011 Jun 13.

18.

Requirement for Lyl1 in a model of Lmo2-driven early T-cell precursor ALL.

McCormack MP, Shields BJ, Jackson JT, Nasa C, Shi W, Slater NJ, Tremblay CS, Rabbitts TH, Curtis DJ.

Blood. 2013 Sep 19;122(12):2093-103. doi: 10.1182/blood-2012-09-458570. Epub 2013 Aug 7.

19.

The SCL complex regulates c-kit expression in hematopoietic cells through functional interaction with Sp1.

Lécuyer E, Herblot S, Saint-Denis M, Martin R, Begley CG, Porcher C, Orkin SH, Hoang T.

Blood. 2002 Oct 1;100(7):2430-40.

20.

SCL, GATA-2 and Lmo2 expression in neurogenesis.

Herberth B, Minkó K, Csillag A, Jaffredo T, Madarász E.

Int J Dev Neurosci. 2005 Aug;23(5):449-63.

PMID:
16011889

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