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Regulation of AMP-activated protein kinase by cAMP in adipocytes: roles for phosphodiesterases, protein kinase B, protein kinase A, Epac and lipolysis.

Omar B, Zmuda-Trzebiatowska E, Manganiello V, Göransson O, Degerman E.

Cell Signal. 2009 May;21(5):760-6. doi: 10.1016/j.cellsig.2009.01.015.


Role of PDE3B in insulin-induced glucose uptake, GLUT-4 translocation and lipogenesis in primary rat adipocytes.

Zmuda-Trzebiatowska E, Oknianska A, Manganiello V, Degerman E.

Cell Signal. 2006 Mar;18(3):382-90.


Phosphorylation and activation of hormone-sensitive adipocyte phosphodiesterase type 3B.

Degerman E, Landström TR, Wijkander J, Holst LS, Ahmad F, Belfrage P, Manganiello V.

Methods. 1998 Jan;14(1):43-53.


Berberine attenuates cAMP-induced lipolysis via reducing the inhibition of phosphodiesterase in 3T3-L1 adipocytes.

Zhou L, Wang X, Yang Y, Wu L, Li F, Zhang R, Yuan G, Wang N, Chen M, Ning G.

Biochim Biophys Acta. 2011 Apr;1812(4):527-35. doi: 10.1016/j.bbadis.2010.10.001.


Acylated and unacylated ghrelin attenuate isoproterenol-induced lipolysis in isolated rat visceral adipocytes through activation of phosphoinositide 3-kinase γ and phosphodiesterase 3B.

Baragli A, Ghè C, Arnoletti E, Granata R, Ghigo E, Muccioli G.

Biochim Biophys Acta. 2011 Jun;1811(6):386-96. doi: 10.1016/j.bbalip.2011.03.001.


Cyclic nucleotide phosphodiesterase 3B is a downstream target of protein kinase B and may be involved in regulation of effects of protein kinase B on thymidine incorporation in FDCP2 cells.

Ahmad F, Cong LN, Stenson Holst L, Wang LM, Rahn Landstrom T, Pierce JH, Quon MJ, Degerman E, Manganiello VC.

J Immunol. 2000 May 1;164(9):4678-88.


C(2)-ceramide influences the expression and insulin-mediated regulation of cyclic nucleotide phosphodiesterase 3B and lipolysis in 3T3-L1 adipocytes.

Mei J, Holst LS, Landström TR, Holm C, Brindley D, Manganiello V, Degerman E.

Diabetes. 2002 Mar;51(3):631-7.


Control of renin secretion from rat juxtaglomerular cells by cAMP-specific phosphodiesterases.

Friis UG, Jensen BL, Sethi S, Andreasen D, Hansen PB, Skøtt O.

Circ Res. 2002 May 17;90(9):996-1003.


Insulin-induced phosphorylation and activation of cyclic nucleotide phosphodiesterase 3B by the serine-threonine kinase Akt.

Kitamura T, Kitamura Y, Kuroda S, Hino Y, Ando M, Kotani K, Konishi H, Matsuzaki H, Kikkawa U, Ogawa W, Kasuga M.

Mol Cell Biol. 1999 Sep;19(9):6286-96.


Down-regulation of cyclic-nucleotide phosphodiesterase 3B in 3T3-L1 adipocytes induced by tumour necrosis factor alpha and cAMP.

Rahn Landström T, Mei J, Karlsson M, Manganiello V, Degerman E.

Biochem J. 2000 Mar 1;346 Pt 2:337-43.


beta-Arrestin-mediated PDE4 cAMP phosphodiesterase recruitment regulates beta-adrenoceptor switching from Gs to Gi.

Baillie GS, Sood A, McPhee I, Gall I, Perry SJ, Lefkowitz RJ, Houslay MD.

Proc Natl Acad Sci U S A. 2003 Feb 4;100(3):940-5.


PKA-dependent activation of PDE3A and PDE4 and inhibition of adenylyl cyclase V/VI in smooth muscle.

Murthy KS, Zhou H, Makhlouf GM.

Am J Physiol Cell Physiol. 2002 Mar;282(3):C508-17.


Protein kinase B activity is required for the effects of insulin on lipid metabolism in adipocytes.

Berggreen C, Gormand A, Omar B, Degerman E, Göransson O.

Am J Physiol Endocrinol Metab. 2009 Apr;296(4):E635-46. doi: 10.1152/ajpendo.90596.2008.

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