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Items: 1 to 20 of 90

1.

A small molecule that binds Hedgehog and blocks its signaling in human cells.

Stanton BZ, Peng LF, Maloof N, Nakai K, Wang X, Duffner JL, Taveras KM, Hyman JM, Lee SW, Koehler AN, Chen JK, Fox JL, Mandinova A, Schreiber SL.

Nat Chem Biol. 2009 Mar;5(3):154-6. doi: 10.1038/nchembio.142.

2.

The hedgehog receptor patched is involved in cholesterol transport.

Bidet M, Joubert O, Lacombe B, Ciantar M, Nehmé R, Mollat P, Brétillon L, Faure H, Bittman R, Ruat M, Mus-Veteau I.

PLoS One. 2011;6(9):e23834. doi: 10.1371/journal.pone.0023834.

3.

Small-molecule modulators of the Sonic Hedgehog signaling pathway.

Stanton BZ, Peng LF.

Mol Biosyst. 2010 Jan;6(1):44-54. doi: 10.1039/b910196a. Review.

PMID:
20024066
4.

Patched1 regulates hedgehog signaling at the primary cilium.

Rohatgi R, Milenkovic L, Scott MP.

Science. 2007 Jul 20;317(5836):372-6.

5.

Fibroblast growth factor blocks Sonic hedgehog signaling in neuronal precursors and tumor cells.

Fogarty MP, Emmenegger BA, Grasfeder LL, Oliver TG, Wechsler-Reya RJ.

Proc Natl Acad Sci U S A. 2007 Feb 20;104(8):2973-8.

6.

Expression of Sonic hedgehog during cell proliferation in the human cerebellum.

Haldipur P, Bharti U, Govindan S, Sarkar C, Iyengar S, Gressens P, Mani S.

Stem Cells Dev. 2012 May 1;21(7):1059-68. doi: 10.1089/scd.2011.0206.

PMID:
21732818
7.

Ptch2 mediates the Shh response in Ptch1-/- cells.

Alfaro AC, Roberts B, Kwong L, Bijlsma MF, Roelink H.

Development. 2014 Sep;141(17):3331-9. doi: 10.1242/dev.110056.

8.

The hedgehog-patched signaling pathway and function in the mammalian ovary: a novel role for hedgehog proteins in stimulating proliferation and steroidogenesis of theca cells.

Spicer LJ, Sudo S, Aad PY, Wang LS, Chun SY, Ben-Shlomo I, Klein C, Hsueh AJ.

Reproduction. 2009 Aug;138(2):329-39. doi: 10.1530/REP-08-0317.

9.

Requirement of Smurf-mediated endocytosis of Patched1 in sonic hedgehog signal reception.

Yue S, Tang LY, Tang Y, Tang Y, Shen QH, Ding J, Chen Y, Zhang Z, Yu TT, Zhang YE, Cheng SY.

Elife. 2014 Jun 12;3. doi: 10.7554/eLife.02555.

10.

Role of Sonic Hedgehog in idiopathic pulmonary fibrosis.

Bolaños AL, Milla CM, Lira JC, Ramírez R, Checa M, Barrera L, García-Alvarez J, Carbajal V, Becerril C, Gaxiola M, Pardo A, Selman M.

Am J Physiol Lung Cell Mol Physiol. 2012 Dec 1;303(11):L978-90. doi: 10.1152/ajplung.00184.2012.

11.

Discovery and evaluation of potential sonic hedgehog signaling pathway inhibitors using pharmacophore modeling and molecular dynamics simulations.

Hwang S, Thangapandian S, Lee Y, Sakkiah S, John S, Lee KW.

J Bioinform Comput Biol. 2011 Dec;9 Suppl 1:15-35.

PMID:
22144251
12.

Hedgehog-signaling is upregulated in non-producing human adrenal adenomas and antagonism of hedgehog-signaling inhibits proliferation of NCI-H295R cells and an immortalized primary human adrenal cell line.

Werminghaus P, Haase M, Hornsby PJ, Schinner S, Schott M, Malendowicz LK, Lammers BJ, Goretzki PE, Müller-Mattheis V, Markus Giessing, Willenberg HS.

J Steroid Biochem Mol Biol. 2014 Jan;139:7-15. doi: 10.1016/j.jsbmb.2013.09.007.

PMID:
24063979
13.

The role of ciliary trafficking in Hedgehog receptor signaling.

Kim J, Hsia EY, Brigui A, Plessis A, Beachy PA, Zheng X.

Sci Signal. 2015 Jun 2;8(379):ra55. doi: 10.1126/scisignal.aaa5622.

14.

Activation of Sonic hedgehog signaling pathway in S-type neuroblastoma cell lines.

Zhou Y, Dai R, Mao L, Xia Y, Yao Y, Yang X, Hu B.

J Huazhong Univ Sci Technolog Med Sci. 2010 Jun;30(3):271-7. doi: 10.1007/s11596-010-0342-7.

PMID:
20556567
15.

LKB1 inhibits breast cancer partially through repressing the Hedgehog signaling pathway.

Zhuang Z, Wang K, Cheng X, Qu X, Jiang B, Li Z, Luo J, Shao Z, Duan T.

PLoS One. 2013 Jul 4;8(7):e67431. doi: 10.1371/journal.pone.0067431.

16.

Sonic hedgehog alleviates the inhibitory effects of high glucose on the osteoblastic differentiation of bone marrow stromal cells.

Guan CC, Yan M, Jiang XQ, Zhang P, Zhang XL, Li J, Ye DX, Zhang FQ.

Bone. 2009 Dec;45(6):1146-52. doi: 10.1016/j.bone.2009.08.009.

PMID:
19683085
17.

Small-molecule modulators of Hedgehog signaling: identification and characterization of Smoothened agonists and antagonists.

Frank-Kamenetsky M, Zhang XM, Bottega S, Guicherit O, Wichterle H, Dudek H, Bumcrot D, Wang FY, Jones S, Shulok J, Rubin LL, Porter JA.

J Biol. 2002 Nov 6;1(2):10.

18.

Protection from lipopolysaccharide-induced pulmonary microvascular endothelial cell injury by activation of hedgehog signaling pathway.

Yang Y, Li Q, Deng Z, Zhang Z, Xu J, Qian G, Wang G.

Mol Biol Rep. 2011 Aug;38(6):3615-22. doi: 10.1007/s11033-010-0473-8.

PMID:
21110116
19.

Sonic hedgehog signaling drives proliferation of synoviocytes in rheumatoid arthritis: a possible novel therapeutic target.

Wang M, Zhu S, Peng W, Li Q, Li Z, Luo M, Feng X, Lin Z, Huang J.

J Immunol Res. 2014;2014:401903. doi: 10.1155/2014/401903.

20.

Shh signaling guides spatial pathfinding of raphespinal tract axons by multidirectional repulsion.

Song L, Liu Y, Yu Y, Duan X, Qi S, Liu Y.

Cell Res. 2012 Apr;22(4):697-716. doi: 10.1038/cr.2011.172.

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