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Items: 1 to 20 of 72

1.

Investigating drug-induced mitochondrial toxicity: a biosensor to increase drug safety?

Pereira CV, Moreira AC, Pereira SP, Machado NG, Carvalho FS, Sardão VA, Oliveira PJ.

Curr Drug Saf. 2009 Jan;4(1):34-54. Review.

PMID:
19149524
2.

The role of mitochondrial dysfunction and drug safety.

Nadanaciva S, Will Y.

IDrugs. 2009 Nov;12(11):706-10. Review.

PMID:
19844857
3.

Investigating mitochondrial dysfunction to increase drug safety in the pharmaceutical industry.

Nadanaciva S, Will Y.

Curr Drug Targets. 2011 Jun;12(6):774-82. Review.

PMID:
21275886
4.

Can drug safety be predicted and animal experiments reduced by using isolated mitochondrial fractions?

Pereira SP, Pereira GC, Moreno AJ, Oliveira PJ.

Altern Lab Anim. 2009 Sep;37(4):355-65. Review.

PMID:
19807208
5.

Strategies to reduce late-stage drug attrition due to mitochondrial toxicity.

Dykens JA, Marroquin LD, Will Y.

Expert Rev Mol Diagn. 2007 Mar;7(2):161-75. Review.

PMID:
17331064
6.

Drug-induced mitochondrial toxicity.

Chan K, Truong D, Shangari N, O'Brien PJ.

Expert Opin Drug Metab Toxicol. 2005 Dec;1(4):655-69. Review.

PMID:
16863431
7.

The role of mitochondria in pharmacotoxicology: a reevaluation of an old, newly emerging topic.

Scatena R, Bottoni P, Botta G, Martorana GE, Giardina B.

Am J Physiol Cell Physiol. 2007 Jul;293(1):C12-21. Epub 2007 May 2. Review.

8.

Mitochondrial off targets of drug therapy.

Wallace KB.

Trends Pharmacol Sci. 2008 Jul;29(7):361-6. doi: 10.1016/j.tips.2008.04.001. Epub 2008 May 22. Review.

PMID:
18501972
9.

Structural alert/reactive metabolite concept as applied in medicinal chemistry to mitigate the risk of idiosyncratic drug toxicity: a perspective based on the critical examination of trends in the top 200 drugs marketed in the United States.

Stepan AF, Walker DP, Bauman J, Price DA, Baillie TA, Kalgutkar AS, Aleo MD.

Chem Res Toxicol. 2011 Sep 19;24(9):1345-410. doi: 10.1021/tx200168d. Epub 2011 Jul 11. Review.

PMID:
21702456
10.

Safety and nutritional assessment of GM plants and derived food and feed: the role of animal feeding trials.

EFSA GMO Panel Working Group on Animal Feeding Trials.

Food Chem Toxicol. 2008 Mar;46 Suppl 1:S2-70. doi: 10.1016/j.fct.2008.02.008. Epub 2008 Feb 13. Review.

PMID:
18328408
11.

The heterozygous Sod2(+/-) mouse: modeling the mitochondrial role in drug toxicity.

Boelsterli UA, Hsiao CJ.

Drug Discov Today. 2008 Nov;13(21-22):982-8. doi: 10.1016/j.drudis.2008.08.002. Epub 2008 Sep 11.

PMID:
18762273
12.

Drug-induced mitochondrial dysfunction in cardiac and skeletal muscle injury.

Sardão VA, Pereira SL, Oliveira PJ.

Expert Opin Drug Saf. 2008 Mar;7(2):129-46. doi: 10.1517/14740338.7.2.129 . Review.

PMID:
18324876
13.

Respirometric Screening Technology for ADME-Tox studies.

Papkovsky DB, Hynes J, Will Y.

Expert Opin Drug Metab Toxicol. 2006 Apr;2(2):313-23. Review.

PMID:
16866616
14.

Targeting drugs to mitochondria.

Heller A, Brockhoff G, Goepferich A.

Eur J Pharm Biopharm. 2012 Sep;82(1):1-18. doi: 10.1016/j.ejpb.2012.05.014. Epub 2012 Jun 9. Review.

PMID:
22687572
15.

Drug delivery to mitochondria: the key to mitochondrial medicine.

Murphy MP, Smith RA.

Adv Drug Deliv Rev. 2000 Mar 30;41(2):235-50. Review.

PMID:
10699318
16.

2011 Annual Meeting of the Safety Pharmacology Society: an overview.

Cavero I.

Expert Opin Drug Saf. 2012 Mar;11(2):341-53. doi: 10.1517/14740338.2012.661412. Epub 2012 Feb 18.

PMID:
22339583
17.

High concordance of drug-induced human hepatotoxicity with in vitro cytotoxicity measured in a novel cell-based model using high content screening.

O'Brien PJ, Irwin W, Diaz D, Howard-Cofield E, Krejsa CM, Slaughter MR, Gao B, Kaludercic N, Angeline A, Bernardi P, Brain P, Hougham C.

Arch Toxicol. 2006 Sep;80(9):580-604. Epub 2006 Apr 6.

PMID:
16598496
18.

Mitochondria and drugs.

Scatena R.

Adv Exp Med Biol. 2012;942:329-46. doi: 10.1007/978-94-007-2869-1_15. Review.

PMID:
22399430
19.

Circumventing the Crabtree effect: replacing media glucose with galactose increases susceptibility of HepG2 cells to mitochondrial toxicants.

Marroquin LD, Hynes J, Dykens JA, Jamieson JD, Will Y.

Toxicol Sci. 2007 Jun;97(2):539-47. Epub 2007 Mar 14.

PMID:
17361016
20.

Preclinical pharmacokinetics: an approach towards safer and efficacious drugs.

Singh SS.

Curr Drug Metab. 2006 Feb;7(2):165-82. Review.

PMID:
16472106

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