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Items: 1 to 20 of 97

1.

Tgfbr1 haploinsufficiency is a potent modifier of colorectal cancer development.

Zeng Q, Phukan S, Xu Y, Sadim M, Rosman DS, Pennison M, Liao J, Yang GY, Huang CC, Valle L, Di Cristofano A, de la Chapelle A, Pasche B.

Cancer Res. 2009 Jan 15;69(2):678-86. doi: 10.1158/0008-5472.CAN-08-3980.

2.

TGFBR1 and cancer susceptibility.

Pasche B, Pennison MJ, Jimenez H, Wang M.

Trans Am Clin Climatol Assoc. 2014;125:300-12. Review.

3.

Gasdermin C Is Upregulated by Inactivation of Transforming Growth Factor β Receptor Type II in the Presence of Mutated Apc, Promoting Colorectal Cancer Proliferation.

Miguchi M, Hinoi T, Shimomura M, Adachi T, Saito Y, Niitsu H, Kochi M, Sada H, Sotomaru Y, Ikenoue T, Shigeyasu K, Tanakaya K, Kitadai Y, Sentani K, Oue N, Yasui W, Ohdan H.

PLoS One. 2016 Nov 11;11(11):e0166422. doi: 10.1371/journal.pone.0166422. eCollection 2016.

4.

Somatic acquisition and signaling of TGFBR1*6A in cancer.

Pasche B, Knobloch TJ, Bian Y, Liu J, Phukan S, Rosman D, Kaklamani V, Baddi L, Siddiqui FS, Frankel W, Prior TW, Schuller DE, Agrawal A, Lang J, Dolan ME, Vokes EE, Lane WS, Huang CC, Caldes T, Di Cristofano A, Hampel H, Nilsson I, von Heijne G, Fodde R, Murty VV, de la Chapelle A, Weghorst CM.

JAMA. 2005 Oct 5;294(13):1634-46.

PMID:
16204663
5.

Glucocorticoids recruit Tgfbr3 and Smad1 to shift transforming growth factor-β signaling from the Tgfbr1/Smad2/3 axis to the Acvrl1/Smad1 axis in lung fibroblasts.

Schwartze JT, Becker S, Sakkas E, Wujak ŁA, Niess G, Usemann J, Reichenberger F, Herold S, Vadász I, Mayer K, Seeger W, Morty RE.

J Biol Chem. 2014 Feb 7;289(6):3262-75. doi: 10.1074/jbc.M113.541052. Epub 2013 Dec 17.

6.

Transforming growth factor beta receptor type II inactivation induces the malignant transformation of intestinal neoplasms initiated by Apc mutation.

Muñoz NM, Upton M, Rojas A, Washington MK, Lin L, Chytil A, Sozmen EG, Madison BB, Pozzi A, Moon RT, Moses HL, Grady WM.

Cancer Res. 2006 Oct 15;66(20):9837-44.

7.

Fibroblast-specific TGF-β-Smad2/3 signaling underlies cardiac fibrosis.

Khalil H, Kanisicak O, Prasad V, Correll RN, Fu X, Schips T, Vagnozzi RJ, Liu R, Huynh T, Lee SJ, Karch J, Molkentin JD.

J Clin Invest. 2017 Oct 2;127(10):3770-3783. doi: 10.1172/JCI94753. Epub 2017 Sep 11.

8.

Constitutively decreased TGFBR1 allelic expression is a common finding in colorectal cancer and is associated with three TGFBR1 SNPs.

Pasche B, Wisinski KB, Sadim M, Kaklamani V, Pennison MJ, Zeng Q, Bellam N, Zimmerman J, Yi N, Zhang K, Baron J, Stram DO, Hayes MG.

J Exp Clin Cancer Res. 2010 May 25;29:57. doi: 10.1186/1756-9966-29-57.

9.

TGF-beta signaling alterations and susceptibility to colorectal cancer.

Xu Y, Pasche B.

Hum Mol Genet. 2007 Apr 15;16 Spec No 1:R14-20. Review.

10.

Smad2 and Smad3 phosphorylated at both linker and COOH-terminal regions transmit malignant TGF-beta signal in later stages of human colorectal cancer.

Matsuzaki K, Kitano C, Murata M, Sekimoto G, Yoshida K, Uemura Y, Seki T, Taketani S, Fujisawa J, Okazaki K.

Cancer Res. 2009 Jul 1;69(13):5321-30. doi: 10.1158/0008-5472.CAN-08-4203. Epub 2009 Jun 16.

11.

Germline allele-specific expression of TGFBR1 confers an increased risk of colorectal cancer.

Valle L, Serena-Acedo T, Liyanarachchi S, Hampel H, Comeras I, Li Z, Zeng Q, Zhang HT, Pennison MJ, Sadim M, Pasche B, Tanner SM, de la Chapelle A.

Science. 2008 Sep 5;321(5894):1361-5. doi: 10.1126/science.1159397. Epub 2008 Aug 14.

12.

Tgfbr1 haploinsufficiency inhibits the development of murine mutant Kras-induced pancreatic precancer.

Adrian K, Strouch MJ, Zeng Q, Barron MR, Cheon EC, Honasoge A, Xu Y, Phukan S, Sadim M, Bentrem DJ, Pasche B, Grippo PJ.

Cancer Res. 2009 Dec 15;69(24):9169-74. doi: 10.1158/0008-5472.CAN-09-1705.

13.

High expression of IGFBP7 in fibroblasts induced by colorectal cancer cells is co-regulated by TGF-β and Wnt signaling in a Smad2/3-Dvl2/3-dependent manner.

Rao C, Lin SL, Ruan WJ, Wen H, Wu DJ, Deng H.

PLoS One. 2014 Jan 10;9(1):e85340. doi: 10.1371/journal.pone.0085340. eCollection 2014.

14.

Smad7 induces hepatic metastasis in colorectal cancer.

Halder SK, Rachakonda G, Deane NG, Datta PK.

Br J Cancer. 2008 Sep 16;99(6):957-65. doi: 10.1038/sj.bjc.6604562.

15.

Progressive tumor formation in mice with conditional deletion of TGF-beta signaling in head and neck epithelia is associated with activation of the PI3K/Akt pathway.

Bian Y, Terse A, Du J, Hall B, Molinolo A, Zhang P, Chen W, Flanders KC, Gutkind JS, Wakefield LM, Kulkarni AB.

Cancer Res. 2009 Jul 15;69(14):5918-26. doi: 10.1158/0008-5472.CAN-08-4623. Epub 2009 Jul 7.

16.

Tgf-beta signaling alterations and colon cancer.

Bellam N, Pasche B.

Cancer Treat Res. 2010;155:85-103. doi: 10.1007/978-1-4419-6033-7_5. Review.

PMID:
20517689
17.

Latent transforming growth factor binding protein 4 regulates transforming growth factor beta receptor stability.

Su CT, Huang JW, Chiang CK, Lawrence EC, Levine KL, Dabovic B, Jung C, Davis EC, Madan-Khetarpal S, Urban Z.

Hum Mol Genet. 2015 Jul 15;24(14):4024-36. doi: 10.1093/hmg/ddv139. Epub 2015 Apr 16.

18.

Transforming Growth Factor β Signaling in Colorectal Cancer Cells With Microsatellite Instability Despite Biallelic Mutations in TGFBR2.

de Miranda NF, van Dinther M, van den Akker BE, van Wezel T, ten Dijke P, Morreau H.

Gastroenterology. 2015 Jun;148(7):1427-37.e8. doi: 10.1053/j.gastro.2015.02.052. Epub 2015 Feb 28.

PMID:
25736321
19.

Involvement of Smad3 phosphoisoform-mediated signaling in the development of colonic cancer in IL-10-deficient mice.

Hachimine D, Uchida K, Asada M, Nishio A, Kawamata S, Sekimoto G, Murata M, Yamagata H, Yoshida K, Mori S, Tahashi Y, Matsuzaki K, Okazaki K.

Int J Oncol. 2008 Jun;32(6):1221-6.

PMID:
18497983
20.

Angiotensin II-dependent TGF-β signaling contributes to Loeys-Dietz syndrome vascular pathogenesis.

Gallo EM, Loch DC, Habashi JP, Calderon JF, Chen Y, Bedja D, van Erp C, Gerber EE, Parker SJ, Sauls K, Judge DP, Cooke SK, Lindsay ME, Rouf R, Myers L, ap Rhys CM, Kent KC, Norris RA, Huso DL, Dietz HC.

J Clin Invest. 2014 Jan;124(1):448-60. doi: 10.1172/JCI69666. Epub 2013 Dec 20.

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